The Origin of the Pfeiffer Effect

  • R. D. Gillard
Part of the NATO Advanced Study Institutes Series book series (ASIC, volume 48)



The intriguing enhancement of optical activity when a racemic (and “kinetically labile”) metal complex of the type (ML3)2+ (M = Zn,Cd, Ni,Co etc; L= 2,2′-bipyridyl or 1,10-phenanthroline) is added to a solution of a cationic ‘environment’ compound (usually an alkaloid) is the best example of the ‘Pfeiffer effect’.


Optical Activity Uranyl Nitrate Preferential Solvation Chiral Discrimination Chiral Solvation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    The International Dictionary of Physics and Chemistry, 2nd edition, 833: van Nostrand, Princeton, 1961.Google Scholar
  2. 2.
    The name was attached to the effect in 1954 by R.C. Brasted and F.P. Dwyer, at a meeting in Indiana: see reference L2J in my present reference [3]. Unfortunately, the name has been taken to include differing classes of interacting compounds by different groups of students. Arguably, it might be restricted to those systems studied by Pfeiffer himself (all containing 2,2’-bipyridyl or 1,10-phenanthroline).Google Scholar
  3. 3.
    R.C. Brasted, V.J. Landis, E.J. Kuhajek, P.E.R. Nordquist, and L. Mayer,in “Coordination Chemistry”, ed. by S. Kirschner, Plenum Press, N.Y., p42 (1969).Google Scholar
  4. 4.
    P. Pfeiffer and K. Quehl, Chem. Ber., 64, 2667 (1931).Google Scholar
  5. 5.
    E.E. Turner and M.M. Harris, Quart. Revs., 1, 299 (1947).CrossRefGoogle Scholar
  6. 6.
    P.E. Schipper, Inorganica Chim. acta, 12, 199 (1975).CrossRefGoogle Scholar
  7. 7.
    P.E. Schipper, J. Amer. Chem. Soc., 100, 1079 (1978) and references therein.CrossRefGoogle Scholar
  8. 8.
    E.B.R. Prideaux and F.T. Winfield, J. Chem. Soc., 1587 (1930).Google Scholar
  9. 9.
    S. Kirschner, J. Indian Chem. Soc., 51, 28 (1974).Google Scholar
  10. 10.
    S. Kirschner, Record Chem. Progress, 32, 29 (1971).Google Scholar
  11. 11.
    S. Kirschner and K. Magnell,in “Coordination Chemistry” (ed. S. Kirschner) Plenum Press, New York, p64 (1969).Google Scholar
  12. 12.
    H. Yoneda, K. Miyoshi, and S. Suzuki, Chem. Letters, 349 (1974): K. Miyoshi, K. Sakata, and H. Yoneda, Chemistry Letters, 1087 (1974): K. Miyoshi, Y. Kuroda, and H. Yoneda, J. Phys. Chem., 80, 270 (1976)CrossRefGoogle Scholar
  13. 12a.
    K. Miyoshi, K. Sakata, and H. Yoneda, J. Phys. Chem., 80, 649 (1976).CrossRefGoogle Scholar
  14. 13.
    B.E. Evans and R.V. Wolfenden, Biochemistry, 12, 392 (1973).CrossRefGoogle Scholar
  15. 14.
    B. Bosnich and D.W. Watts, Inorg. Chem., 14, 41 (1975)Google Scholar
  16. 15.
    R.D. Gillard and P.A. Williams, Transition Metal Chem., 2, 14, (1977).CrossRefGoogle Scholar
  17. 16.
    R.D. Gillard, L.A.P. Kane-Maguire, and P.A. Williams, J. Chem. Soc. (Dalton) 1039 (1977).Google Scholar
  18. 17.
    J.W. Bunting and W.G. Meathrel, Canadian J. Chem.,52, 975 (1974)CrossRefGoogle Scholar
  19. 18.
    M.S. Henry and M.Z. Hoffman, J. Amer. Chem. Soc., 99, 5201 (1977).CrossRefGoogle Scholar
  20. 19.
    D.J. Norris, J.W. Bunting, and W.G. Meathrel, Canadian J. Chem., 55, 2601 (1977).CrossRefGoogle Scholar
  21. 20.
    R.D. Gillard and J.R. Lyons, Chem. Comm., 873 (1973).Google Scholar
  22. 21.
    W.S. Walters, unpublished work.Google Scholar
  23. 22.
    E.J. Kuhajek, Ph.D. thesis, Univ. of Minnesota (1964).Google Scholar
  24. 23.
    K. Miyoshi, Y. Kuroda, H. Okazaki, and H. Yoneda, Bull. Chem. Soc. Japan, 50, 1476 (1977).CrossRefGoogle Scholar
  25. 24.
    T. Fujiwara and Y. Yamamoto, XVII International Conference on Coord. Chem., Hamburg, 166 (1976).Google Scholar
  26. 25.
    P. Pfeiffer and K. Nakatsuka, Chem. Ber., 66, 410 (1933).Google Scholar
  27. 26.
    L.A. Mayer and R.C. Brasted, J. Coord. Chem., 3, 85 (1973).CrossRefGoogle Scholar
  28. 27.
    This value refers to the ratio K=[Bipy.H2O]/[Bipy].Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1979

Authors and Affiliations

  • R. D. Gillard
    • 1
  1. 1.University College, CardiffCardiffWales

Personalised recommendations