Chiral Discrimination

  • D. P. Craig
Part of the NATO Advanced Study Institutes Series book series (ASIC, volume 48)


Chiral discrimination is a new term for an old idea, going back at least to Pasteur and perhaps before. Where the pairinteraction energy of two molecules or ions is different for the two enantiomers of one acting on the same enantiomer of the other there is chiral discrimination. In its application to small molecules, at distances greater than closest approach, where the molecules had some freedom of rotation, the current revival of interest stems from the work of F.P. Dwyer and collaborators in the 1950’s [1]. Since then theoretical papers have appeared and many new and precise experimental measurements have been made enabling magnitudes to be estimated. In the discussion to follow the main results and problems are surveyed. Much of the theory as well as the experimental basis has been reviewed quite recently [2,3]. These sources may be used for fuller accounts. In the following a wider viewpoint is attempted, with some emphasis on recent development.


Tartaric Acid Dispersion Interaction Transition Moment Multipole Moment Chiral Molecule 
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  1. 1.
    F.P. Dwyer, N. Gyarfas and M.F. O’Dwyer, Nature, 168, 29, (1951), and later papers.CrossRefGoogle Scholar
  2. 2.
    D.P. Craig and D.P. Mellor, Topics in Current Chemistry, 63, 1, (1976).CrossRefGoogle Scholar
  3. 3.
    S.F. Mason, Ann. Rep., 73, 53. (1976).Google Scholar
  4. 4.
    K. Mizumachi, J. Coord. Chem., 3, 191, (1973).CrossRefGoogle Scholar
  5. 5.
    A. Albert, Selective Toxivity, 5th Ed., Chapman, 1973.Google Scholar
  6. 6.
    F.A. Quoicho, et al, Symp. Quantit. Biol., 36, 561, (1971).CrossRefGoogle Scholar
  7. 7.
    J.P. Greenstein and M. Winitz, Chemistry of the Amino Acids, Vol. I, p.645, John Wiley, New York, 1961.Google Scholar
  8. 8.
    F.P. Dwyer and N.R. Davies, Trans. Faraday Soc., 50, 24, (1954).CrossRefGoogle Scholar
  9. 9.
    S. Takagi, R. Fuj ishoro and K. Amaya, Chem. Commun., 480. (1968).Google Scholar
  10. 10.
    M. Leclercq, A. Collet and J. Jacques, Tetrahedron, 9, 1, (1976).Google Scholar
  11. 11.
    B. Bosnich and D.W. Watts, Inorg. Chem., 14, 47, (1975).CrossRefGoogle Scholar
  12. 12.
    R.D. Gillard, in press.Google Scholar
  13. 13.
    B. Chion, A. Lajzerowicz, A. Collet and J. Jacques, Acta. Cryst., B32, 339, (1976).Google Scholar
  14. 14.
    R. Silbey, J. Jortner, M. Vala and S.A. Rice, J. Chem. Phys., 42, 2948, (1965).CrossRefGoogle Scholar
  15. 15.
    D.P. Craig and T. Thirunamachandran, Proc. Phys. Soc., 84, 781, (1964).CrossRefGoogle Scholar
  16. 16.
    E.A. Power and S. Zienau, Phil. Trans. Roy. Soc. (Lond.), A251, 427, (1959).CrossRefGoogle Scholar
  17. 17.
    D.P. Craig and P.E. Schipper, Proc. Roy. Soc. (Lond.), A342, 19, (1975).CrossRefGoogle Scholar
  18. 18.
    C. Mavroyannis and M.J. Stephen, Mol. Phys., 5, 629, (1962).CrossRefGoogle Scholar
  19. 19.
    D.P. Craig, E.A. Power and T. Thirunamachandran, Proc. Roy. Soc., A322, 165 (1971).CrossRefGoogle Scholar
  20. 20.
    P.E. Schipper, in course of publication.Google Scholar
  21. 21.
    F. London, J. Phys. Chem., 46, 305, (1942).CrossRefGoogle Scholar
  22. 22.
    C.A. Coulson and P.L. Davies, Trans. Faraday Soc., 48, 777, (1952).CrossRefGoogle Scholar
  23. 23.
    R. Kuroda, S.F. Mason, C.D. Roger and R.H. Seal, Chem. Physics Letters, 57, 1, (1978).CrossRefGoogle Scholar
  24. 24.
    D.P. Craig, L. Radom and P.J. Stiles, Proc. Roy. Soc., A343, 11, (1975).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1979

Authors and Affiliations

  • D. P. Craig
    • 1
  1. 1.Research School of ChemistryThe Australian National UniversityCanberraAustralia

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