Abstract
Cardiovascular disease is the main cause of mortality in countries with a high standard of living such as Canada, the United States of America, Great Britain and Scandinavia. Atherosclerosis appears to be the principal underlying condition responsible for the clinical manifestations of cardiovascular diseases and other circulatory disorders, heart attacks and sudden death. Atherosclerosis is characterized by the presence in the arterial walls of lipid-rich deposits. These deposits can cause partial or even complete occlusion of certain arteries. It is still impossible to prevent the formation of atherosclerotic deposits or to induce their regression. Despite 200 years of observation and research, the cause of atherosclerosis remains largely unknown and it is still impossible, for all practical purposes, to modify to any great degree its course or avoid its consequences1.
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References
Borhani NO: Primary prevention of coronary heart disease: a critique. Am J Cardiol, 40: 251–259, 1977
Keys A: Coronary heart disease in seven countries. American Heart Association, Monograph 29. Circulation, 41:suppl I, 1970
Masironi R: Dietary factors and coronary heart disease. Bull WHO, 42: 103–114, 1970.
Armstrong BK, Mann JI, Adelstein AM, Eskin F: Commodity consumption and ischemic heart disease mortality, with special reference to dietary practices. J Chron Dis, 28: 455–469, 1975
Kannel WB: Some lessons in cardiovascular epidemiology from Framingham. Am J Cardiol, 37: 269–282, 1976
Stamler J: Population studies. In Levy RI, Rifkind BM, Dennis BH, Ernst ND (eds) Nutrition, Lipids, and Coronary Heart Disease. A Global View, p 57. New York, Raven Press, 1979
Tyroler HA, Heyden S, Bartel A, Cassel J, Cornoni JC, Hames CG, Kleinbaum D: Blood pressure and cholesterol as coronary risk factors. Arch Intern Med, 128: 907–914, 1971
Miller NE, Thelle DS, Førde OH, Mjøs OD: The Troms¢ heart-study. High-density lipoprotein and coronary heart-disease: a prospective case-control study. Lancet, 1: 965–970, 1977
Robertson TL, Kato H, Gordon T, Kagan A, Rhoads GG, Land CE, Worth RM, Belsky JL, Dock DS, Miyanishi M, Kawamoto S: Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. Coronary heart disease risk factors in Japan and Hawaii. Am J Cardiol, 39: 244–249, 1977
McGee D, Gordon T: The Framingham Study—an epidemiological investigation of cardiovascular disease. Section 31. The results of the Framingham Study applied to four other U.S.-based epidemiologic studies of cardiovascular disease, U.S. Department of Health, Education, and Welfare. DHEW Publication No (NM) 76–1083, Washington, DC, 1976
Tibblin G, Wilhelmsen L, Werkö L: Risk factors for myocardial infarction and death due to ischemic heart disease and other causes. Am J Cardiol, 35: 514–522, 1975
Sherwin R: Controlled trials of the diet-heart hypothesis: some comments on the experimental unit. Am J Epidemiol, 108: 92–99, 1978
Wright IS: Correct levels of serum cholesterol. Average vs normal vs optimal. JAMA, 236: 261–262, 1976
Hulley SB, Rosenman RH, Bawol RD, Brand RJ: Epidemiology as a guide to clinical decisions. The association between triglyceride and coronary heart disease. N Engl J Med, 302: 1383–1389, 1980
Turpeinen O. Karvonen MJ, Pekkarinen M, Miettinen M, Elosuo R, Paavilainen E: Dietary prevention of coronary heart disease: the finnish mental hospital study. Int J Epidemiol, 8: 99–118, 1979
Dayton S, Pearce ML, Hashimoto S, Dixon WJ, Tomiyasu U: A controlled clinical trial of a diet high in unsaturated fat in preventing complications of atherosclerosis. Circulation, 40 (suppl 2): 1–63, 1969
Stamler J: Acute myocardial infarction—progress in primary prevention. Br Heart J, 33 (suppl): 145–164, 1971
Christakis G, Rinzler SH, Archer M, Krauss A: Effect of the anti-coronary club program on coronary heart disease risk-factor status. JAMA, 198: 597–604, 1966
Miettinen M, Turpeinen O, Karvonen MJ, Elosuo R, Paavilainen E: Effect of cholesterol-lowering diet on mortality from coronary heart-disease and other causes. A twelve-year clinical trial in men and women. Lancet, 2: 835–838, 1972
Oliver MF, Heady JA, Morris JN, Cooper J: A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Report from the Committee of Principal Investigators. Br Heart J, 40: 1069–1103, 1978
Halperin M, Cornfield J, Mitchell SC: Effect of diet on coronary-heart-disease mortality. Lancet, 2: 438–439, 1973
Ahrens EH Jr: The management of hyperlipidemias: whether, rather than how. Ann Intern Med, 85: 87–93, 1976
Rose GA, Thomson, WB, Williams RT: Corn oil in treatment of ischaemic heart disease. Br Med J, 1: 1531–1533, 1965
Morris JN, Ball KP: Controlled trial of soya-bean oil in myocardial infarction. Report of a research committee to the medical research council. Lancet, 2: 693–699, 1968
Leren P: The effect of plasma cholesterol lowering diet in male survivors of myocardial infarction. A controlled clinical trial. Acta Med Scand, 466 (suppl): 5–92, 1966
Bierenbaum ML, Fleischman Al, Raichelson, RI, Hayton T, Watson PB: Ten-year experience of modified-fat diets on younger men with coronary heart-disease. Lancet, 1: 1404–1407, 1973
Woodhill JM, Palmer AJ, Leelarthalpin B, McGilchrist C, Blacket RB: Low fat, low cholesterol diet in secondary prevention of coronary heart disease. In Kritchevsky D, Paoletti R, Holmes WL (eds) Drugs, Lipids and Atherosclerosis, pp 317–330. New York, Plenum Press, 1977
Coronary Drug Project Research Group: The Coronary Drug Project. Initial findings leading to modifications of its research protocol. JAMA, 214: 1303–1313, 1970
Coronary Drug Project Research Group: The Coronary Drug Project. Findings leading to further modifications of its protocol with respect to dextrothyroxine. JAMA, 220: 996–1008, 1972
Coronary Drug Project Research Group: The Coronary Drug Project. Findings leading to discontinuation of the 2.5mg/day estrogen JAMA, 226: 652–657, 1973
Coronary Drug Project Research Group: Clofibrate and niacin in coronary heart disease. JAMA, 231: 360–381, 1975
Oliver MF: Ischaemic heart disease: a secondary prevention trial using clofibrate. Report by a research committee of the Scottish Society of Physicians. Br Med J, 4: 775–784, 1971
Anonyme: Trial of clofibrate in the treatment of ischaemic heart disease. Five-year study by a group of physicians of the Newcastle upon Tyne region. Br Med J, 4: 767–775, 1971
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© 1981 Springer Science+Business Media New York
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Brisson, G.J. (1981). The major intervention studies. In: Lipids in Human Nutrition. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-7212-5_7
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DOI: https://doi.org/10.1007/978-94-015-7212-5_7
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