Abstract
Of the neuroactive substances present in the type I cells of the mammalian carotid body, the catecholamines are the most abundant and have been the focus of intense research in recent years. (see Mills et al., 1978, Fidone et al., 1980, McQueen, 1983), Yet the precise role of catecholamines in chemoreception remains undefined, in part as a consequence of confusion over the widely discrepant experimental results. Thus, a number of pharmacological studies have provided contradictory findings from the in vivo versus in vitro carotid body preparations (compare Docherty and McQueen [1979] and Monti-Bloch and Eyzaguirre [1980]) as well as from amongst different species using the same type of preparation (Monti-Bloch and Eyzaguirre, 1980), and even from the same species and type of preparation (Folgering et al., 1982 va. Gonsalves et al., 1984). Furthermore, the interpretation of even non-controversial experimental results is rendered more difficult because of the multiplicity of possible loci of action for the catecholamines (i.e., blood vessels, sympathetic nerve endings, type I cells, sensory nerve endings, etc.). Finally, there is fundamental disagreement amongst biochemical studies regarding the effects of natural stimulation on the metabolism of carotid body catecholamines (see Mills and Slotkin, 1975 vs. Zapata et al., 1969, see also Fidone and Gonzalez, 1985).
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© 1987 J.A. Ribeiro and David J. Pallot
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Rigual, R., Gonzalez, E., Gonzalez, C., Jones, L., Fidone, S. (1987). A Comparative Study of the Metabolism of Catecholamines in the Rabbit and Cat Carotid Body. In: Ribeiro, J.A., Pallot, D.J. (eds) Chemoreceptors in Respiratory Control. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-1155-1_14
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