Abstract
The value of maintenance therapy with neuroleptic drugs to reduce the risk of relapse in schizophrenic patients is well documented (see review by Davis, 1975; Goldberg et al., 1979; Hogarty et al., 1974). Schizophrenic patients maintained on placebo have two to three times higher relapse rates than do similar patients treated with standard neuroleptic medications.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brown, W. A., Laughren, J., Chrisholm, E., and Williams, B.W. 1982. Low serum neuroleptic levels predict relapse in schizophrenic patients. Arch. Gen. Psychiatry 39:998–1000.
Casper, R., Garver, D. L., Dekirmenjian, H., Chang, S., and Davis, J. 1980. Phenothiazine levels in plasma and red blood cells. Arch. Gen. Psychiatry 37:301–305.
Davis, J.M. 1975. Overview: Maintenance therapy in psychiatry: I. Schizophrenia, Am. J. Psychiatry 132:1237–1245.
Davis, J.M., and Baldessarini, R.J. 1980. What is the best maintenance dose of neuroleptics? Psychiatry Research 3:115–122.
Dyskin, M.W., Javaid, J.I., Chang, S.S., Schaffer, C., Shabid, A., and Davis, J.M. 1981. Fluphenazine pharmacokinetics and therapeutic response. Psychopharmacology 73:205–210.
Garver, D.L., Dekirmenjian, H., Davis, J.M., Casper, R., and Ericksen, S. 1977. Neuroleptic drug levels and therapeutic response: Preliminary observations with red blood cell-bound butaperazine. Am. J. Psychiatry 134:304–307.
Goldberg, S.C., Schooler, N., Hogarty, G.E., and Roper, M. 1977. Prediction of relapse in schizophrenic outpatients treated by drugs and sociotherapy. Arch. Gen. Psychiatry 34:171–184.
Hogarty, G.E., Goldberg, S.C., Schooler, N.R., and Ulrich, R.F. 1974. Drugs and sociotherapy in the after care of schizophrenic patients. Arch. Gen. Psychiatry 31:603–618.
Kane, J.M., Ritkin, A., Woerner, M., and Reardon, G. 1980. Low-dose neuroleptics in outpatient schizophrenics. Psychopharmacol. Bull. 18:20–21.
Schooler, H., Levine, J., Severe, J., Brauzer, B., DiMascio, H., Klerman, G.L., and Tuasen, V.B. 1980. Prevention of relapse in schizophrenia: An evaluation of fluphenazine decanoate. Arch. Gen. Psychiatry 37:16–24.
Shvartsburd, A., Dekirmenjian, H., and Smith, R. C. 1983. Blood levels of haloperidol in schizophrenic patients. Journal of Clinical Psychopharmacology 3:7–12.
Shvartsburd, A., Nwokeafor, V., and Smith, R. C. in press. Red blood cell and plasma levels of thioridazine and mesoridazine in schizophrenic patients. Psychopharmacology.
Smith, R.C., Vroulis, G., Shvartsburd, A., Allen, R., Lewis, N., Schoolar, J.C., Chojnacki, M., and Johnson, R. 1982. RBC and plasma levels of haloperidol and clinical response in schizophrenia. Am. J. Psychiatry 139:1054–1056.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Spectrum Publications, Inc.
About this chapter
Cite this chapter
Sajadi, C., Smith, R.C., Shvartsburd, A., Morton, V., Gordon, J.R., Mirabi, M. (1984). Neuroleptic Blood Level Monitoring in Maintenance Studies of Schizophrenic Outpatients. In: Mirabi, M., Feldman, L. (eds) The Chronically Mentally Ill. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-9825-7_10
Download citation
DOI: https://doi.org/10.1007/978-94-011-9825-7_10
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-9827-1
Online ISBN: 978-94-011-9825-7
eBook Packages: Springer Book Archive