Abstract
This chapter describes examples of the utilisation of short-lived radionuclides in the assessment of drug formulations and the in vivo disposition of drugs. It includes examples obtained in the author’s laboratory and does not represent an exhaustive account of the current literature on the subject. Tablet disintegration as a function of gastric emptying and formulation is discussed. It has been shown that, by labelling one batch of tablets with technetium-99m and another with indium-113m, it is possible to observe by external scintigraphy the behaviour of the two formulations concomitantly in the same individual. Data are presented which show the applicability of perturbed angular correlation to the study of the dissolution of water soluble substances from solid dosage forms in man.
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© 1982 C.G. Wilson, J.G. Hardy, M. Frier and S.S. Davis
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Digenis, G.A. (1982). The Utilisation of Short-Lived Radionuclides in the Assessment of Formulation and in Vivo Disposition of Drugs. In: Wilson, C.G., Hardy, J.G., Frier, M., Davis, S.S. (eds) Radionuclide Imaging in Drug Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-9728-1_9
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DOI: https://doi.org/10.1007/978-94-011-9728-1_9
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