Abstract
This series of short communications presents, in miniature, the diversity of applications which exists for scintigraphic studies in drug formulation. It may be classified into three main groups reflecting the three major divisions seen when considering the subject as a whole. In the first group, representing the field most closely akin to nuclear medicine, radionuclide tracers are used to demonstrate the progress of pathological conditions, or to show the response of these conditions to various therapeutic regimes. The second group uses radionuclides to demonstrate physiological or metabolic processes. Again it is possible to extend this group to include an assessment of the response of these processes to drug therapy. Thirdly, there is the group of studies in which radionuclides are incorporated as an integral part of the drug formulation; allowing the fate of the formulation to be monitored externally.
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References
Clark J C, Buckingham P D (1975) Short-Lived Radioactive Gases for Clinical Use, Butterworths, London
Rose I A, Gunberg-Manago M, Korey S R, Ochoa S (1954) Enzymatic phosphorylation of acetate, J. Biol. Chem. 211: 737–756
Bishop H M, Blarney R W, Morris A H, Rose D H, Preston B, Lane J, Doyle P J (1979) Bone scanning: its lack of value in the follow-up of patients with breast cancer, Br. J. Surg. 66: 752–754
Alpsten M, Ekenved G, Sülvell (1976) A profile scanning method of studying the release properties of different types of tablets in man, Acta Pharm. Suec. 13: 107–122
Bechgaard H, Ladefoged K (1978) Distribution of pellets in the gastrointestinal tract. The influence on transit time exerted by the density or diameter of pellets, J. Pharm. Pharmacol. 30: 690–692
Rahman Y, Rosenthal MW (1973) A new approach to the therapy of metal poisoning: liposome encapsulation of chelating agents, Radiat. Res. 55: 516–517
Rahman Y-E, Rosenthal M W, Cerny E A (1973) Intracellular plutonium: removal by liposome encapsulated chelating agent, Science 180: 300–302
Rosenthal M W, Rahman Y E, Moretti E S, Cerny E A (1975) Removal of polymeric plutonium by DTPA directed into cells by liposome encapsulation, Radiat. Res. 63: 262–274
Bullingham R E S, McQuay H J, Dwyer D, Allen M C, Moore R A (1981) Sublingual buprenorphine used post-operatively: clinical observations and patient pharmacokinetic analysis, Br. J. Clin. Pharmacol, (in press)
Edge W G, Cooper G M, Morgan M (1979) Analgesic effects of sublingual buprenorphine, Anaesthesia 34: 463–467
Houde R W, Wallenstein S L, Beaver W T (1965) in: deStevens G (ed) Analgetics, Academic Press, New York, pp75–122
Iwamoto K, Klaassen C D (1977) First-pass effect of morphine in rats, J. Pharmacol. Exp. Ther. 200: 236–244
Jasinski D R, Pevnick J S, Griffith J D (1978) Human pharmacology and abuse potential of the analgesic buprenorphine. A potential agent for treating narcotic addiction, Arch. Gen. Psychiatry 35: 501–516
Kay B (1978) A double-blind comparison of morphine and buprenorphine in the prevention of pain after operation, Br. J. Anaesth. 50: 605–609
Ranee M J, Shillingford J S (1977) The metabolism of phenolic opiates by rat intestine, Xenobiotica 7: 529–536
Robbie D S (1979) A trial of sublingual buprenorphine in cancer pain, Br. J. Clin. Pharmacol. 7 (Supplement 3): 315S-317S
Arrowsmith M, Hadgraft J, Kellaway I W (1980) The formulation of cortisone esters in liposomes, J. Pharm. Pharmacol. 32 (Supplement): 60P
Lubran M, Pearson J D (1958) A screening test for steatorrhoea using 131I-labelled triolein, J. Clin. Pathol. 11: 165–169
McDougall I R, Dunnick J K, Goris M L, Kriss J P (1975) In vivo distribution of vesicles loaded with radiopharmaceuticals: a study of different routes of administration, J. Nucl. Med. 16: 488–491
Wagner J G, Nelson E (1963) Per cent absorbed time plots derived from blood level and/or urinary excretion data, J. Pharm. Sci. 52: 610–611
Buckwalter F H, Dickison H L (1958) The effect of vehicle and particle size on the absorption, by the intramuscular route, of procaine penicillin G suspensions, J. Amer. Pharm. Ass. 47: 661–666
Huh Y, Donaldson G W, Johnston F J (1974) A radiation-induced bonding of iodine at the surface of uniform polystyrene particles, Radiât. Res. 60: 42–53
Kanke M, Simmons G H, Weiss D L, Bivins B A, DeLuca P P (1980) Clearance of 141Ce-labeled microspheres from blood and distribution in specific organs following intravenous and intraarterial administration in beagle dogs, J. Pharm. Sci. 69: 755–762
Tanaka T, Kobayashi H, Okumura K, Muranishi S, Sezaki H (1974) Intramuscular absorption of drugs from oily solutions in the rat, Chem. Pharm. Bull. 22: 1275–1284
Hagan P L, Krejcarek G E, Taylor A, Alazraki N (1978) A rapid method for the labeling of albumin microspheres with In-113 and In-111: concise communication, J. Nucl. Med. 19: 1055–1058
Marty J J, Oppenheim R C (1977) Colloidal systems for drug delivery, Aust. J. Pharm. Sci. 6: 65–76
Taplin G V, Johnson D E, Dore E K, Kaplan H S (1964) Suspensions of radioalbumin aggregates for photoscanning the liver, spleen, lung and other organs, J. Nucl. Med. 5: 259–275
Wochner R D, Adatepe M, Van Amburg A, Potchen E J (1970) A new method for estimation of plasma volume with the use of the distribution space of indium-113m-transferrin, J. Lab. Clin. Med. 75: 711–720
Zolle I, Rhodes B A, Wagner H N (1970) Preparation of metabolizable radioactive human serum albumin microspheres for studies of the circulation, Int. J. Appl. Radiat. Isot. 21: 155–167
Armstrong N A, James K C (1980) Drug release from lipid-based dosage forms. II, Int. J. Pharm. 6: 195–204
Hunt J N, Knox M T (1969) A relation between the chain length of fatty acids and the slowing of gastric emptying, J. Physiol. (Lond.) 194: 327–336
Palin K, Davis S S, Phillips A J, Whalley D, Wilson C G (1980) Effect of lipid vesicles on the oral absorption of a model compound (DDT), J. Pharm. Pharmacol. 32 (Supplement): 62P
Palin K J, Davis S S, Phillips A J, Wilson C G (1981) The lymphatic absorption of a model compound (DDT), in: Proceedings of the First European Congress of Biopharmaceutics and Pharmacokinetics, Libraire Lavoisier, Paris (in press)
Higuchi T (1963) Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices, J. Pharm. Sci. 52: 1145–1149
Bryan A J, Kaur R, Robinson G, Thomas N W, Wilson C G (1980) Histological and physiological studies on the intestine of the rat exposed to solutions of Myrj 52 and PEG 2000, Int. J. Pharm. 7: 145–156
Chang T M S (1972) Artificial Cells, Thomas, Springfield
Chang T M S (1977) in: Chang T M S (ed) Biomedical Applications of Immobilized Enzymes and Proteins, Volume 1, Plenum Press, New York, pp69–90
Florence A T, Whateley T L, Wood D A (1979) Potentially biodegradable microcapsules with poly (alkyl 2-cyanoacrylate) membranes, J. Pharm. Pharmacol. 31: 422–424
Wood D A, Whateley T L, Florence A T (1979) Microencapsulation of histidase for enzyme replacement therapy, J. Pharm. Pharmacol. 31 (Supplement): 79P
Wood D A, Whateley T L, Florence A T (1981) Formation of poly(butyl 2-cyanoacrylate) microcapsules and the microencapsulation of aqueous solutions of (125I)-labelled proteins, Int. J. Pharm. 8: 35–43
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© 1982 C.G. Wilson, J.G. Hardy, M. Frier and S.S. Davis
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Frier, M. (1982). Poster Abstracts. In: Wilson, C.G., Hardy, J.G., Frier, M., Davis, S.S. (eds) Radionuclide Imaging in Drug Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-9728-1_19
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DOI: https://doi.org/10.1007/978-94-011-9728-1_19
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