Abstract
Liposomes are small vesicles produced from phospholipid dispersions. They comprise concentric layers of bilayer structures and have both lipid and aqueous regions. Originally they were a research tool in the study of cell membranes (Bangham et al. 1965), but are now being considered widely as potential carriers of therapeutic agents to specific sites in the body. Work in this area has been reviewed by Tyrrell et al. (1976). Several articles have been published describing the use of liposomes containing cytotoxic drugs, chelating agents, hormones and other materials entrapped in the aqueous regions (Gregoriadis et al. 19 74, Ryman 1976) and administered by various routes to animals and humans (Juliano and Stamp 1978, Weissman et al. 1978). If liposomes are to be used as carriers of drugs to particular targets it is important to study both their in vivo distribution as well as their ability to reach a target and release the entrapped agent at the intended site.
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References
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© 1982 C.G. Wilson, J.G. Hardy, M. Frier and S.S. Davis
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Jeyasingh, K. (1982). In Vivo Distributions of 99mTc-Labelled Liposomes. In: Wilson, C.G., Hardy, J.G., Frier, M., Davis, S.S. (eds) Radionuclide Imaging in Drug Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-9728-1_16
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DOI: https://doi.org/10.1007/978-94-011-9728-1_16
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