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Prostaglandin-Cyclic Nucleotide Interactions in Mammalian Tissues

  • Chapter
Prostaglandins: Chemical and Biochemical Aspects

Abstract

Consideration of cyclic nucleotides in this review will be restricted to cyclic-3′,5′-adenosine monophosphate (cyclic-AMP) and cyclic-3′,5′-guanosine monophosphate (cyclic-GMP). Although other cyclic nucleotides have been prepared, and in some cases shown to exhibit biological activity, these will not be included in this discussion since they have not been shown to occur in mammalian tissues or fluids, clearly an essential requirement for a role in cell function. In contrast to the cyclic nucleotides, a great variety of prostaglandins, (PGs), as defined by the presence of a C-20 prostanoic acid skeleton, have been detected in tissues and body fluids. Our discussions will be limited mainly to those of the E- and F-series. They are the initial products of the enzymes, endoperoxide isomerase and endoperoxide reductase and thus ‘primary prostaglandins’, and most studies relating prostaglandins to cyclic nucleotides have been confined to these two series. Prostaglandins of the A- and B-series are derived from E-prostaglandins and may simply be the metabolic degradation products, although a physiological role, particularly for PGA2 in kidney function, seems possible.

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  1. F. A. Kuehl Jr.
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  1. Department of Obstetrics and Gynaecology, University of Singapore, Kandang Kerbau Hospital, Hampshire Road, Singapore 8, Republic of Singapore

    S. M. M. Karim (Research Professor of Obstetrics and Gynaecology) (Research Professor of Obstetrics and Gynaecology)

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Kuehl, F.A., Cirillo, V.J., Oien, H.G. (1976). Prostaglandin-Cyclic Nucleotide Interactions in Mammalian Tissues. In: Karim, S.M.M. (eds) Prostaglandins: Chemical and Biochemical Aspects. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-9648-2_5

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