Skip to main content
SpringerLink
Log in

Inhibition of Prostaglandin Biosynthesis

  • Chapter
Prostaglandins: Chemical and Biochemical Aspects

Abstract

Little evidence exists for stored prostaglandins in tissues (Jouvenaz, Nugteren, Beerthuis and Van Dorp, 1970) and a capacity of a tissue to release prostaglandins seems to reflect principally the capacity for biosynthesis of these compounds. Since prostaglandins represent a diverse family of oxygenated derivatives formed from certain polyunsaturated fatty acids, the

Formation and degradation of prostaglandins.

biosynthesis of prostaglandins consists of many steps that involve a variety of different enzymes and cofactors. Inhibition of prostaglandin synthesis may thus occur by blocking any of the several processes that are involved. A brief summary of some of the metabolic events leading to the different prostaglandins is given in Figure 3.1. Because of the diversity of these processes and the stimuli and mediators that appear to modify these reactions it is expected that a wide variety of chemical agents will diminish the formation of prostaglandins in vivo. We will indicate some of the events of prostaglandin biosynthesis known to be influenced by chemical agents, and will suggest a logical framework for comparing the relative inhibitory activity of these different agents.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ahern, D. G. and Downing, D. T. (1970). Inhibition of prostaglandin biosynthesis by eicosa-5,8,11,14-tetraynoic acid. Biochim. Biophys. Acta, 210, 456–461

    PubMed  CAS  Google Scholar 

  • Alcindor, L. G., Etienne, J., Flottes, D. and Polonovski, J. (1974). Phophospholipase plastmatiques dans l’embolie graisseuse. Ann. Biol. Clin., 32, 257–260

    CAS  Google Scholar 

  • Allwood, G., Asherson, G. L., Davey, M. J. and Goodford, P. J. (1971). Immunol., 21, 509–516

    CAS  Google Scholar 

  • Al-Mondhiry, H., Marcus, A. J. and Spaet, T. H. (1970). On the mechanism of platelet function inhibition by acetylsalicylic acid. Proc. Soc. Exp. Biol. Med., 133, 632–636

    PubMed  CAS  Google Scholar 

  • Altman, M., Oka, H. and Field, J. B. (1966). Effect of TSH, acetylcholine, epinephrine, serotonin and synkavite on 32P incorporation into phospholipids in dog thyroid slices. Biochim. Biophys. Acta, 116, 586–588

    PubMed  CAS  Google Scholar 

  • Anderson, A. J., Brocklehurst, W. E. and Willis, A. L. (1971). Evidence for the role of lysosomes in the formation of prostaglandins during carrageenin induced inflammation in the rat. Pharm. Res. Commun., 3, 13–19

    CAS  Google Scholar 

  • Anderson, B. M., Reynolds, M. L. and Anderson, C. D. (1966). Nitrogen base inhibition of yeast alcohol dehydrogenase. Biochim. Biophys. Acta, 113, 235–243

    PubMed  CAS  Google Scholar 

  • Arens, D., Seilmeier, W., Weber, F., Kloos, G. and Grosch, W. (1973). Purification and properties of a carotene co-oxidizing lipoxygenase from peas. Biochim. Biophys. Acta, 327, 295–305

    PubMed  CAS  Google Scholar 

  • Arrigoni-Martelli, E., Selva, D. and Schiatti, P. (1973). Different efficacy of anti-inflammatory drugs in inhibiting the reactions to intradermal phospholipase A and PGE2. J. Int. Med. Res., 1, 120–126

    CAS  Google Scholar 

  • Baccino, F. M. (1969). Lysosomal involvement in liver cell vacuolation by hypoxia. Br. J. Exp. Path., 50, 150–152

    CAS  Google Scholar 

  • Beckemeier, H., Giessler, A. J. and Hirschelmann, R. (1974). Prostaglandins and inflammation. Polish J. Pharmacol. Pharm., 26, 5–23

    Google Scholar 

  • Beerthuis, R. K., Nugteren, D. H., Pabon, H. J. J., Steenhoek, A. and Van Dorp, D. A. (1971). Synthesis of a series of polyunsaturated fatty acids, their potencies as essential fatty acids and as precursors of prostaglandins. Rec. Trav. Chim., 90, 943–960

    CAS  Google Scholar 

  • Berry, P. A., Collier, H. O. J. and Holgate, J. A. (1963). Bronchoconstrictor action in vivo of slow-reacting substance in anaphylaxis (SRS-A) and its antagonism. J. Physiol. (London), 165, 41P–42P

    Google Scholar 

  • Block, A. J., Feinberg, H., Herbaczynska-Cedro, K. and Vane, J. (1975). Anoxia-induced release of prostaglandins in rabbit isolated hearts. Circulation Res., 36, 34–42

    PubMed  CAS  Google Scholar 

  • Booyse, F. M. and Rafelson, M. E. Jr. (1972). Regulation and mechanism of platelet aggregation. Ann. N. Y. Acad. Sci., 201, 37–60

    PubMed  CAS  Google Scholar 

  • Bourne, H. R., Lichtenstein, L. M., Melmon, K. L., Henney, C. S., Weinstein, Y. and Shearer, G. M. (1974). Modulation of inflammation and immunity by cyclic AMP. Science, 184, 19–28

    PubMed  CAS  Google Scholar 

  • Burke, G. (1970a). Effects of prostaglandins on basal and stimulated thyroid function. Amer. J. Physiol., 218, 1445–1452

    PubMed  CAS  Google Scholar 

  • Burke, G. (1970b). On the role of adenyl cyclase activation and endocytosis in thyroid slice metabolism. Endocrinology, 86, 353–359

    PubMed  CAS  Google Scholar 

  • Burke, G. (1974). Effects of prostaglandin antagonists on the induction of cyclic 3′5′-adenosine monophosphate formation and thyroid hormone secretion in vitro.Endocrinology, 94, 91–96

    PubMed  CAS  Google Scholar 

  • Burke, G., Chang, L. L. and Szabo, M. (1973). Thyrotropin and cyclic nucleotide effects on prostaglandin levels in isolated thyroid cells. Science, 180, 872–875

    PubMed  CAS  Google Scholar 

  • Busuttil, R. W., Ignarro, L. J., Shirkey, H. C. and George, W. J. (1975). Improved recovery of the anoxic heart with methylprednisolone: a mechanism involving lysosomal enzyme release by cyclic nucleotides. Fed. Proc. (Fed. Amer. Soc. Exp. Biol.), 34, 265

    Google Scholar 

  • Chan, H. W.-S. (1973). Soya-bean lipoxygenase: an iron-containing dioxygenase. Biochim. Biophys. Acta, 327, 32–35

    PubMed  CAS  Google Scholar 

  • Chiappe De Cingolani, G. E., Van Den Bosch, H. and Van Deenen, L. L. M. (1972). Phospholipase A and lysophospholipase activities in isolated fat cells: effect of cyclic 3′5′-AMP. Biochim. Biophys. Acta, 260, 387–392

    CAS  Google Scholar 

  • Christ, E. J. and Nugteren, D. H. (1970). The biosynthesis and possible function of prostaglandins in adipose tissue. Biochim. Biophys. Acta, 218, 296–307

    CAS  Google Scholar 

  • Collier, H. O. J. and Shorley, P. G (1960) Analgesic antipyretic drugs as antagonists of bradykinin. Brit. J. Pharmacol., 15, 601–610

    PubMed  CAS  Google Scholar 

  • Cornai, K., Prose, P. and Farber, S. J. (1974). Correlation of renal medullary prostaglandin content and renal interstitial cell lipid droplets. Prostaglandins, 6, 375–379

    Google Scholar 

  • Cook, H. W. and Lands, W. E. M. (1975). Evidence for an activating factor formed during prostaglandin biosynthesis. Biochem. Biophys. Res. Commun., 65, 464–471

    PubMed  CAS  Google Scholar 

  • Cooper, M. F. and Webster, G. R. (1970). The differentiation of phospholipase A1 and A2 in rat and human nervous tissues. J. Neurochem., 17, 1543–1554

    PubMed  CAS  Google Scholar 

  • Dalton, C. and Hope, H. R. (1973). Inability of prostaglandin synthesis inhibitors to affect adipose tissue lipolysis. Prostaglandins, 4, 641–651

    PubMed  CAS  Google Scholar 

  • Deby, C., Bacq, Z. M. and Simon, D. (1973). In vitro inhibition of the biosynthesis of a prostaglandin by gold and silver. Biochem. Pharmacol., 22, 3141–3143

    CAS  Google Scholar 

  • Delezenne, M. C. and Ledebt, S. (1911). Formation de substances toxiques aux dé pens du vitellus de Foeuf sourmis à Taction du cobra. Compt. Rend. Acad. Sci. Paris, 153, 81–86

    CAS  Google Scholar 

  • De Robertis, E. D. P. and Sabatini, D. D. (1960). Submicroscopic analysis of the secretory process in the adrenal medulla. Fed. Proc. (Fed. Amer. Soc. Exp. Biol.), 19, 70

    Google Scholar 

  • De Robertis, E. D. P. and Vaz Ferreira, A. (1957). Electron microscope study of the excretion of catechol-containing droplets in the adrenal medulla. Exp. Cell. Res., 12, 568–574

    Google Scholar 

  • Di Rosa, M. (1974). Prostaglandins, leucocytes and non-steroidal anti-inflammatory drugs. Polish J. Pharmacol. Pharm., 26, 29–36

    Google Scholar 

  • Di Rosa, M., Papadimitriou, J. M. and Willoughby, D. A. (1971). A histopathological and pharmacological analysis of the mode of action of non-steroidal anti-inflammatory drugs. J. Path., 105, 239–256

    PubMed  Google Scholar 

  • Dixon, M. (1953). The determination of enzyme inhibitor constants. Biochem. J., 55, 170–171

    PubMed  CAS  Google Scholar 

  • Douglas, J. R. Jr., Johnson, E. M. Jr., Marshall, G. R., Jaffe, B. M. and Needleman, P. (1973). Stimulation of splenic prostaglandin release by angiotensin and specific inhibition by cysteine8-AII. Prostaglandins, 3, 67–74

    PubMed  CAS  Google Scholar 

  • Downing, D. T., Ahern, D. G. and Bachta, M. (1970). Enzyme inhibition by acetylenic compounds. Biochem. Biophys. Res. Commun., 40, 215–223

    Google Scholar 

  • Downing, D. T., Barve, J. A., Gunstone, F. D., Jacobsberg, F. R. and Jie, M. L. K. (1972). Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthetase. Biochim. Biophys. Acta, 280, 343–347

    PubMed  CAS  Google Scholar 

  • Drazen, J. M. and Austin, K. F. (1974). Effects of intravenous administration of slow-reacting substance of anaphylaxis, histamine, bradykinin and prostaglandin F2α on pulmonary mechanics in the guinea pig. J. Clin. Inv., 53, 1679–1685

    Google Scholar 

  • Duchesne, M.-J., Etienne, J., Grüber, A. and Polonovski, J. (1972). Action des plaquettes sur la phophospholipase plasmatique. Biochimie, 54, 257–260

    PubMed  CAS  Google Scholar 

  • Eakins, K. E. (1974). Prostaglandins and prostaglandin synthetase inhibitors: actions in ocular disease. In Prostaglandin Synthetase Inhibitors (H. J. Robinson and J. R. Vane, editors), 343–352 (New York: Raven Press)

    Google Scholar 

  • Ehrenpreis, S., Greenberg, J. and Belman, S. (1973). Prostaglandins reverse inhibition of electrically-induced contractions of guinea pig ileum by morphine, indomethacin and acetylsalicylic acid. Nature (New Biol.), 245, 280–282

    CAS  Google Scholar 

  • Elsbach, P. (1968). Increased synthesis of phospholipid during phagocytosis. J. Clin. Inves., 47, 2217–2229

    CAS  Google Scholar 

  • Elsbach, P., Goldman, J. and Patriarca, P. (1972b). Phospholipid metabolism by phagocytic cells VI. Observations on the fate of phospholipids of granulocytes and ingested Escherichia coli during phagocytosis. Biochim. Biophys. Acta, 280, 33–44

    PubMed  CAS  Google Scholar 

  • Elsbach, P., Patriarca, P., Pettis, P., Stossel, T. P., Mason, R. J. and Vaughan, M. (1972a). The appearance of lecithin-32P, synthesized from lysolecithin-32P, in phagosomes of polymorphonuclear leukocytes. J. Clin. Inves., 51, 1910–1914

    CAS  Google Scholar 

  • Farmer, J. B., Farrar, D. G. and Wilson, J. (1974). Antagonism of tone and prostaglandin-mediated responses in a tracheal preparation by indomethacin and SC-19220. Br. J. Pharmac, 51, 559–565

    Google Scholar 

  • Feinstein, M. B. (1964). Reaction of local anesthetics with phospholipids. J. Gen. Physiol., 48, 357–374

    PubMed  CAS  Google Scholar 

  • Feldberg, W., Holden, H. F. and Kellaway, C. H. (1938). The formation of lysolecithin and of a muscle-stimulating substance by snake venoms. J. Physiol. (London), 94, 232–248

    CAS  Google Scholar 

  • Feldberg, W. and Kellaway, C. H. (1937). Liberation of histamine from the perfused lung by snake venoms. J. Physiol. (London), 90, 257–279

    CAS  Google Scholar 

  • Ferber, E., Reilly, C. E., de Pasquale, G. and Resch, K. (1973). Lymphocyte stimulation by mitogens: increase in membrane fluidity caused by changes of fatty acid moities of phospholipids. In Lymphocyte Recognition and Effector Mechanisms (K. Lindahl-Kiessling and D. Osoba, editors), 529–534 (New York: Academic Press)

    Google Scholar 

  • Ferguson, W. W., Glenn, T. M. and Lefer, A. M. (1972). Mechanisms of production of circulatory shock factors in isolated perfused pancreas. Amer. J. Physiol., 222, 450–457

    PubMed  CAS  Google Scholar 

  • Ferraris, V. A. and DeRubertis, F. R. (1974). Release of prostaglandin by mitogen- and antigen-stimulated leukocytes in culture. J. Clin. Jnves., 54, 378–386

    CAS  Google Scholar 

  • Fjalland, B. (1974). Inhibition by non-steroidal anti-inflammatory agents of the release of rabbit aorta contracting substance and prostaglandins from chopped guinea pig lungs. J. Pharm. Pharmac, 26, 448–451

    CAS  Google Scholar 

  • Flower, R. J., Cheung, H. S. and Cushman, D. W. (1973). Quantitative determination of prostaglandins and malondialdehyde formed by the arachidonate oxygenase (prostaglandin synthetase) system of bovine seminal vesicle. Prostaglandins, 4, 325–341

    PubMed  CAS  Google Scholar 

  • Flower, R. J., Gryglewski, R., Herbaczynska-Cernik, K. and Vane, J. R. (1972). Effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nature (New Biol.), 238, 104–106

    CAS  Google Scholar 

  • Flower, R. J. and Vane, J. R. (1972). Inhibition of prostaglandin synthetase in brains explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature (London), 240, 410–411

    CAS  Google Scholar 

  • Flower, R. J. and Vane, J. R. (1974a). Inhibition of prostaglandin biosynthesis. Biochem. Pharmacol., 23, 1439–1450

    PubMed  CAS  Google Scholar 

  • Flower, R. J. and Vane, J. R. (1974b). Some pharmacologic and biochemical aspects of prostaglandin biosynthesis and its inhibition. In Prostaglandin Synthesis Inhibitors (H. J. Robinson and J. R. Vane, editors), 9–18 (New York: Raven Press)

    Google Scholar 

  • Franson, R., Beckerdite, S., Wang, P., Waite, M. and Elsbach, P. (1973). Some properties of phospholipases of alveolar macrophages. Biochim. Biophys. Acta, 296, 365–373

    PubMed  CAS  Google Scholar 

  • Franson, R., Patriarca, P. and Elsbach, P. (1974). Phospholipid metabolism by phagocytic cells. Phospholipases A2 associated with rabbit polymorphonuclear leukocyte granules. J. Lipid Res., 15, 380–388

    PubMed  CAS  Google Scholar 

  • Franson, R. C. and Waite, M. (1973). Lysosomal phospholipases A1 and A2 of normal and bacillus calmette guerin-induced alveolar macrophages. J. Cell Biol., 56, 621–627

    PubMed  CAS  Google Scholar 

  • Franson, R., Waite, M. and LaVia, M. (1971). Identification of phospholipase A1 and A2 in the soluble fraction of rat liver lysosomes. Biochemistry, 10, 1942–1946

    PubMed  CAS  Google Scholar 

  • Franson, R., Waite, M. and Weglicki, W. (1972). Phospholipase A activity of lysosomes of rat myocardial tissue. Biochemistry, 11, 472–476

    PubMed  CAS  Google Scholar 

  • Fredholm, B. B. and Hedqvist, P. (1975). Indomethacin and the role of prostaglandin in adipose tissue. Biochem. Pharmacol., 24, 61–66

    PubMed  CAS  Google Scholar 

  • Fukazawa, T. and Privett, O. S. (1972). Biosynthesis of protein relative to the accumulation of fat in the liver of EFA deficient rats. Lipids, 1, 387–393

    Google Scholar 

  • Gabr, Y. (1956). Observations on a substance in human plasma which gives a slow contraction of guinea pig gut in vitro. Brit. J. Pharm., 11, 93–98

    CAS  Google Scholar 

  • Giacobini, E., Sedvall, G. and Uvnäs, B. (1965). Phospholipase A activity of isolated rat mast cells. Exp. Cell Res., 37, 368–375

    PubMed  CAS  Google Scholar 

  • Giroud, J. P., Velo, J. P., Timsit, J. and Willoughby, D. A. (1974). The distribution of prostaglandins in inflammatory exudates. Polish J. Pharmacol. Pharm., 26, 39

    CAS  Google Scholar 

  • Glatt, M., Peskar, B. and Brune, K. (1974). Leukocytes and prostaglandins in acute inflammation. Experientia, 30, 1257–1259

    PubMed  CAS  Google Scholar 

  • Grant, J. A. and Lichtenstein, L. M. (1974). Release of slow reacting substance of anaphylaxis from human leukocytes. J. Immunol, 112, 897–904

    PubMed  CAS  Google Scholar 

  • Grant, N. H., Alburn, H. E. and Kryzanauskas, C. (1971). Stabilization of serum albumin by anti-inflammatory drugs. Biochem. Pharmacol., 20, 2137–2140

    PubMed  CAS  Google Scholar 

  • Grisolia, S., Mendelson, J. and Diederich, D. (1969). Inactivation of enzymes by therapeutic concentrations of aspirin and salicylate. Nature (London), 223, 79–80

    CAS  Google Scholar 

  • Gryglewski, R. J. (1974). Structure-activity relationships of some prostaglandin synthetase inhibitors. In Prostaglandin Synthetase Inhibitors (H. J. Robinson and J. R. Vane, editors), 33–52 (New York: Raven Press)

    Google Scholar 

  • Gryglewski, R. and Vane, J. R. (1972). The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins. Brit. J. Pharmacol., 46, 449–457

    CAS  Google Scholar 

  • Ham, E. A., Cirillo, V. J., Zanetti, M., Shen, T. Y. and Kuehl, F. A. Jr. (1972). Studies on the mode of action of non-steroidal anti-inflammatory agents. In Prostaglandins in Cellular Biology (P. W. Ramwell and B. B. Pharriss, editors), 345–352 (New York: Plenum Press)

    Google Scholar 

  • Hamberg, M., (1972). Inhibition of prostaglandin synthesis in man. Biochem. Biophys. Res. Commun., 49, 720–726

    PubMed  CAS  Google Scholar 

  • Hamberg, M. and Samuelsson, B. (1967). On the mechanism of the biosynthesis of prostaglandins E1 and F1α. J. Biol. Chem., 242, 5336–5343

    PubMed  CAS  Google Scholar 

  • Hamberg, M. and Samuelsson, B. (1974). Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc. Nat. Acad. Sci. U.S.A., 71, 3400–3404

    CAS  Google Scholar 

  • Hamberg, M., Svensson, J., Wakabayashi, T. and Samuelsson, B. (1974). Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. Proc. Nat. Acad. Sci. U.S.A., 71, 345–349

    CAS  Google Scholar 

  • Hamberg, M., Svensson, J. and Samuelsson, B. (1974). Prostaglandin endoperoxides. A new concept concerning the mode of action and release of prostaglandins. Proc. Nat. Acad. Sci. U.S.A., 71, 3824–3828

    CAS  Google Scholar 

  • Hawkins, D., Pinckard, R. N. and Farr, R. S. (1968). Acetylation of human serum albumin by acetylsalicylic acid. Science, 160, 780–781

    PubMed  CAS  Google Scholar 

  • Hawkins, D., Pinckard, R. N., Crawford, I. P. and Farr, R. S. (1969). Structural changes in human serum albumin induced by ingestion of acetylsalicylic acid. J. Clin. Inves., 48, 536–542

    CAS  Google Scholar 

  • Haye, B., Champion, S. and Jacquemin, C. (1973). Control by TSH of a phospholipase A2 activity, a limiting factor in the biosynthesis of prostaglandins in the thyroid. FEBS. Letters, 30, 253–260

    PubMed  CAS  Google Scholar 

  • Haye, B., Champion, S. and Jacquemin, C. (1974). Existence of two pools of prostaglandins during stimulation of the thyroid by TSH. FEBS Letters, 41, 89–93

    PubMed  CAS  Google Scholar 

  • Hedqvist, P. (1970) Studies on the effect of prostaglandins E1 and E2 on the sympathetic neuromuscular transmission in some animal tissues Acta Physiol. Scand. Suppl., 345, 1–40

    PubMed  CAS  Google Scholar 

  • Hedqvist, P. and von Euler, U. S. (1972). Prostaglandin controls neuromuscular transmission in guinea pig vas deferens. Nature (New Biol.), 236, 113–115

    CAS  Google Scholar 

  • Higgs, G. A. and Youlten, L. J. F. (1972). Prostaglandin production by rabbit peritoneal polymorphonuclear leukocytes in vitro. Brit. J. Pharmacol., 44, 330P

    CAS  Google Scholar 

  • Hittelman, K. J. and Butcher, R. W. (1973). Effects of antilipolytic agents and α-adrenergic antagonists on cyclic AMP metabolism in hamster white adipocytes. Biochim. Biophys. Acta, 316, 403–410

    PubMed  CAS  Google Scholar 

  • Ho, P. P. K. and Esterman, M. A. (1974). Fenoprofen: inhibitor of prostaglandin synthesis. Prostaglandins, 6, 107–113

    CAS  Google Scholar 

  • Hoffstein, S., Zurier, R. B. and Weissmann, G. (1974). Mechanisms of lysosomal enzyme release from human leucocytes. III. Quantitative morphologic evidence for an effect of cyclic nucleotides and colchicine on degranulation. Clin. Immunol. Immunopath., 3, 201–217

    CAS  Google Scholar 

  • Högberg, B. and Uvnas, B. (1960). Further observations on the disruption of rat mesentery mast cells caused by compound 48/80, antigen-antibody reaction, lecithinase A and antigen. Acta Physiol. Scand., 48, 133–145

    PubMed  Google Scholar 

  • Horodniak, J. W., Julius, M., Zarembo, J. E. and Bender, A. D. (1974). Inhibitory effects of aspirin and indomethacin on the biosynthesis of PGE2 and PGF2α. Biochem. Biophys. Res. Commun., 57, 539–545

    CAS  Google Scholar 

  • Horton, E. W. (1973). Prostaglandins at adrenergic nerve-endings. Brit. Med. Bull., 29, 148–151

    PubMed  CAS  Google Scholar 

  • Horton, E. W., Jones, R. L. and Marr, C. G. (1973). Effects of aspirin on prostaglandin and fructose levels in human semen. J. Reprod. Fert., 33, 385–392

    CAS  Google Scholar 

  • Hucker, H. B., Zacchei, A. G., Cox, S. V., Brodie, D. A. and Cantwell, N. H. R. (1966). Studies on the absorption, distribution and excretion of indomethacin in various species. J. Pharm. Exp. Ther., 153, 237–249

    CAS  Google Scholar 

  • Ignarro, L. J. (1971). Effects of anti-inflammatory drugs on the stability of rat liver lyso-somes in vitro. Biochem. Pharmacol., 20, 2847–2860

    PubMed  CAS  Google Scholar 

  • Illiano, G. and Cuatrecasas, P. (1971). Endogenous prostaglandins modulate lipolytic processes in adipose tissue. Nature (New Biol.), 234, 72–74

    CAS  Google Scholar 

  • Jahng, H. N. (1975). Effect of phytohemagglutinin (RHA-P) on prostaglandin synthesis in an in vitro leukocyte culture. Fed. Proc. (Fed. Amer. Soc. Exp. Biol.), 34, 1030

    Google Scholar 

  • Janszen, F. H. A. and Nugteren, D. H. (1971). Histochemical localization of prostaglandin synthethase. Histochemie, 27, 159–164

    PubMed  CAS  Google Scholar 

  • Jouvenaz, G. H., Nugteren, D. H., Beerthuis, R. K. and Van Dorp, D. A. (1970). A sensitive method for the determination of prostaglandins by gas chromatography with electron-capture detection. Biochim. Biophys. Acta, 202, 231–234

    PubMed  CAS  Google Scholar 

  • Junstad, M. and Wennmalm, A. (1974). Release of prostaglandin from the rabbit isolated heart following vagal nerve stimulation or acetylcholine infusion. Brit. J. Pharmacol., 52, 375–379

    CAS  Google Scholar 

  • Kies, M. W., Haining, J. L., Pistorius, E., Schroeder, D. H., and Axelrod, B. (1969). On the question of the identity of soybean ‘lipoxidase’. Biochem. Biophys. Res. Commun., 36, 312–315

    PubMed  CAS  Google Scholar 

  • Kienberg, D. and Samuelsson, B. (1965). The biosynthesis of prostaglandin E1 studied with specifically 3H-labelled 8,11,14-eicosatrienoic acids. Acta Chem. Scand., 19, 534–534

    Google Scholar 

  • Kloeze, J. (1969). Relationship between chemical structure and platelet-aggregation activity of prostaglandins. Biochim Biophys. Acta, 187, 285–292

    PubMed  CAS  Google Scholar 

  • Klotz, I. M. and Tarn, J. W. O. (1973). Acetylation of sickle cell hemoglobin by aspirin. Proc. Nat. Acad. Sci. U.S.A., 70, 1313–1315

    CAS  Google Scholar 

  • Kocsis, J. J., Hernandovich, J., Silver, M. J., Smith, J. B. and Ingerman, C. (1973). Duration of inhibition of platelet prostaglandin formation and aggregation by ingested aspirin or indomethacin. Prostaglandins, 3, 141–144

    PubMed  CAS  Google Scholar 

  • Ku, E. C. and Wasvary, J. M. (1973). Inhibition of prostaglandin synthetase by Su-21524. Fed. Proc. (Fed. Amer. Soc. Exp. Biol.), 32, 803

    Google Scholar 

  • Ku, E. C., Wasvary, J. S., Court, R. H. and Wasvary, J. M. (1974). Properties of bovine brain prostaglandin synthetase and its susceptibility to inhibition by non-steroidal antiinflammatory agents. Fed. Proc. (Fed. Amer. Soc. Exp. Biol.), 33, 590

    Google Scholar 

  • Ku, E. C., Wasvary, J. M. and Cash, W. D. (1975). Diclofenac sodium (GP 45840, Voltaren), a potent inhibitor of prostaglandin synthetase. Biochem. Pharmacol., 24, 641–643

    PubMed  CAS  Google Scholar 

  • Kunze, H., Bohn, E. and Vogt, W. (1974b). Effects of local anaesthetics on prostaglandin biosynthesis in vitro. Biochim. Biophys. Acta, 360, 260

    PubMed  CAS  Google Scholar 

  • Kunze, H., Nahas, N. and Wurl, M. (1974a). Phospholipases in human seminal plasma. Biochim. Biophys. Acta, 348, 35–44

    PubMed  CAS  Google Scholar 

  • Kunze, H. and Vogt, W. (1971). Significance of phospholipase A for prostaglandin formation. Ann. N. Y. Acad. Sci., 180, 123–125

    PubMed  CAS  Google Scholar 

  • Kwant, W. O. and Seeman, P. (1969). The displacement of membrane calcium by a local anaesthetic (chlorpromazine). Biochim. Biophys. Acta, 193, 338–349

    PubMed  CAS  Google Scholar 

  • Lands, W. E. M., Cook, H. W. and Rome, L. H. (1976). Prostaglandin biosynthesis: consequences of oxygenase mechanism upon in vitro assays of drug effectiveness. In Advances in Prostaglandin and Thromboxane Research (B. Samuelsson and R. Paoletti, editors), 7–17 (New York: Raven Press)

    Google Scholar 

  • Lands, W. E. M. and Samuelsson, B. (1968). Phospholipid precursors of prostaglandins. Biochim. Biophys. Acta, 164, 426–429

    PubMed  CAS  Google Scholar 

  • Lands, W., Lee, R. and Smith, W. (1971). Factors regulating the biosynthesis of various prostaglandins. Ann. N.Y. Acad. Sci., 180, 107–122

    PubMed  CAS  Google Scholar 

  • Lands, W. E. M., LeTellier, P., Rome, L. and Vanderhoek, J. (1972). Alternate modes of inhibiting the prostaglandin synthetic capacity of sheep vesicular gland preparations. Fed. Proc. (Fed. Amer. Soc. Exp. Biol.), 31, 476

    Google Scholar 

  • Lands, W. E. M., LeTellier, P. R., Rome, L. H. and Vanderhoek, J. Y. (1973). Inhibition of prostaglandin biosynthesis. Adv. Biosci., 9, 15–28

    Google Scholar 

  • Lands, W. E. M., LeTellier, P. R., Rome, L. and Vanderhoek, J. Y. (1974). Regulation of prostaglandin synthesis. In Prostaglandin Synthetase Inhibitors (H. J. Robinson and J. R. Vane, editors), 1–7 (New York: Raven Press)

    Google Scholar 

  • Larsson, C. and ÄnggÃ¥rd, E. (1973). Regional difference in the formation and metabolism of prostaglandins in the rabbit kidney. Eur. J. Pharmacol., 21, 30–36

    PubMed  CAS  Google Scholar 

  • Lee, R. E. (1974). The influence of psychotropic drugs on prostaglandin biosynthesis. Prostaglandins, 5, 63–68

    PubMed  CAS  Google Scholar 

  • Lee, R. E. and Lands, W. E. M. (1972). Co-factors in the biosynthesis of prostaglandins F1α and F2α. Biochim. Biophys. Acta, 260, 203–211

    PubMed  CAS  Google Scholar 

  • LeTellier, P. R., Smith, W. L. Jr. and Lands, W. E. M. (1973). Effect of metal-complexing agents on the oxygenase activity of sheep vesicular glands. Prostaglandins, 4, 837–843

    PubMed  CAS  Google Scholar 

  • Levine, L. (1972). Prostaglandin production by mouse fibrosarcoma cells in culture: Inhibition by indomethacin and aspirin. Biochim. Biophys. Res. Commun., 47, 888–896

    CAS  Google Scholar 

  • Limas, C. J. and Cohn, J. N. (1973). Isolation and properties of myocardial prostaglandin synthetase. Cardiovascular Res., 7, 623–628

    CAS  Google Scholar 

  • Lindner, H. R., Zor, U., Bauminger, S., Tsafriri, A., Lamprecht, S. A., Koch, Y., Antebi, S. and Schwartz, A. (1974). Use of prostaglandin synthetase inhibitors in analysing the role of prostaglandin in reproductive physiology. In Prostaglandin Synthetase Inhibitors (H. R. Robinson and J. R. Vane, editors), 271–287 (New York: Raven Press)

    Google Scholar 

  • Lloveras, J. and Blazy, L. D. (1973). Hydrolysis of [3H, 14C]phosphatidylethanolamines by acid phospholipases A of sub-cellular fractions of rat spleen. Eur. J. Biochim., 33, 567–577

    CAS  Google Scholar 

  • Madaoui, S., Rappaport, L. and Nunez, J. (1974). Prostaglandins and in vitro TSH-dependent iodide binding by rat thyroid glands. Biochemie (Paris), 56, 109–113

    CAS  Google Scholar 

  • Maddox, I. S. (1973). The role of copper in prostaglandin synthesis. Biochim. Biophys. Acta, 306, 74–81

    PubMed  CAS  Google Scholar 

  • Markus, H. B. and Ball, E. G. (1969). Inhibition of lipolytic processes in rat adipose tissue by anti-malarial drugs. Biochim. Biophys. Acta, 187, 486–491

    PubMed  CAS  Google Scholar 

  • Marshall, N. J., Von Borcke, S. and Malan, P. G. (1974). Adenylate cyclase activity in plasma-membrane preparations from bovine thyroid: stimulation by thyrotrophin and prostaglandin E1 and inhibition by propranolol. Biochem. Soc. Trans., 2, 450

    CAS  Google Scholar 

  • Mashiter, K. and Field, J. B. (1974a). Prostaglandins and the thyroid gland. Fed. Proc. (Fed. Amer. Soc. Exp. Biol.), 33, 78–80

    CAS  Google Scholar 

  • Mashiter, K. and Field J. B. (1974b). The thyroid gland. In The Prostaglandins (P. W. Ramwell, editor), 49–73 (New York: Plenum Press)

    Google Scholar 

  • Massini, P. and Lüscher, E. F. (1974). Some effects of ionophores for divalent cations on blood platelets. Comparison with the effects of thrombin. Biochim. Biophys. Acta, 372, 109–121

    PubMed  CAS  Google Scholar 

  • McCall, E. and Youlten, L. J. F. (1974). Prostaglandin E1 synthesis by phagocytosing rabbit polymorphonuclear leucocytes; its inhibition by indomethacin and its role in Chemotaxis. Polish J. Pharmacol. Pharm., 26, 37–38

    Google Scholar 

  • McCracken, J. A., Carlson, J. C., Glew, M. E., Goding, J. R., Baird, D. T., Gréen, K. and Samuelsson, B. (1972). Prostaglandin F2α identified as luteolytic hormone in sheep. Nature (New Biol.), 238, 129–134

    CAS  Google Scholar 

  • McDonald-Gibson, R. G., Flack, J. D. and Ramwell, P. W. (1973). Inhibition of prostaglandin biosynthesis by 7-oxa-and 5-oxa-prostaglandin analogues. Biochem. J., 132, 117–120

    PubMed  CAS  Google Scholar 

  • McGiff, J. C., Crowshaw, K. and Itskovitz, H. D. (1974). Prostaglandins and renal function. Fed. Proc. (Fed. Amer. Soc. Exp. Biol.), 33, 39–47

    CAS  Google Scholar 

  • Mills, D. G., Hirst, M. and Philp, R. B. (1974b). The effects of some salicylate analogues on human blood platelets: 2. The role of platelet acetylation in the inhibition of platelet aggregation. Life Sci., 14, 673–684

    PubMed  CAS  Google Scholar 

  • Mills, D. G., Philp, R. B. and Hirst, M. (1974a). The effects of some salicylate analogues on human blood platelets: 1. Structure-activity relationships and the inhibition of platelet aggregation. Life Sci., 14, 659–672

    PubMed  CAS  Google Scholar 

  • Moncada, S., Ferriera, S. H. and Vane, J. R. (1973). Prostaglandins, aspirin-like drugs and the oedema of inflammation. Nature (London), 246, 217–219

    CAS  Google Scholar 

  • Muirhead, E. E., Brown, G. B., Germain, G. S. and Leach, B. E. (1970). The renal medulla as an antihypertensive organ. J. Lab. Clin. Med., 75, 641–651

    Google Scholar 

  • Mujovic, V., Gross, D., Jubiz, W. and Fisher, J. W. (1975). Blockade of erythropoietin (ESF) and prostaglandins (PGE) production in dogs following renal artery (RA) constriction and hypoxia by indomethacin (I). Fed. Proc. (Fed. Amer. Soc. Exp. Biol.), 34, 356

    Google Scholar 

  • Nachbaur, J., Colbeau, A. and Vignais, P. M. (1972). Distribution of membrane-confined phospholipases A in the rat hepatocyte. Bioehim. Biophys. Acta, 274, 426–446

    CAS  Google Scholar 

  • Nachman, R. L., Weksler, B. and Ferris, B. (1970). Increased vascular permeability produced by human platelet granule cationic extract. J. Clin. Invest., 49, 274–281

    PubMed  CAS  Google Scholar 

  • Newcombe, D. S., Thanassi, N. M. and Ciosek, C. P. Jr. (1974). Cartilage cyclic nucleotide phosphodiesterase: Inhibition by anti-inflammatory agents. Life Sciences, 14, 505–519

    PubMed  CAS  Google Scholar 

  • Nishizawa, E. E., Miller, W. L., Gorman, R. R. and Bundy, G. L. (1975). Prostaglandin D2 as a potential antithrombotic agent. Prostaglandins, 9, 109–121

    PubMed  CAS  Google Scholar 

  • Northover, B. J. (1971). Mechanism of the inhibitory action of indomethacin on smooth muscle. Brit. J. Pharmac, 41, 540–541

    CAS  Google Scholar 

  • Nugteren, D. H. (1970). Inhibition of prostaglandin biosynthesis by 8-cis, 12-trans, 14 cis-eicosa acid and 5-cis, 8-cis 12-trans, 14-cis-eicosatetraenoic acid. Biochim. Biophys. Acta, 210, 171–176

    PubMed  CAS  Google Scholar 

  • Nugteren, D. H. (1975). Arachidonate lipoxygenase in blood platelets. Bioehim. Biophys. Acta, 380, 299–307

    CAS  Google Scholar 

  • Nugteren, D. H., Beerthuis, R. K. and Van Dorp, D. A. (1966). The enzymic conversion of all cis-8,11,14-eicosatrienoic acid into prostaglandin E1. Recl. Trav. Chim. Pays. Bas Belg., 85, 405–419

    CAS  Google Scholar 

  • Nugteren, D. H. and Hazelhof, E. (1973). Isolation and properties of intermediates in prostaglandin biosynthesis. Bioehim. Biophys. Acta, 326, 448–461

    CAS  Google Scholar 

  • O’Brien, J. R. (1968). Effects of salicylates on human platelets. Lancet, 1, 779–783

    PubMed  Google Scholar 

  • O’Brien, J. R., Finch, W. and Clark, E. (1970). A comparison of an effect of different antiinflammatory drugs on human platelets. J. Clin. Path., 23, 522–525

    PubMed  Google Scholar 

  • Odajima, T. (1971). Myeloperoxidase of the leukocyte of normal blood. II. The oxidation-reduction reaction mechanism of the myeloperoxidase system. Bioehim. Biophys. Acta, 235, 52–60

    CAS  Google Scholar 

  • Orange, R. P., Valentine, M. D. and Austen, K. F. (1967). Release of slow-reacting substance of anaphylaxis in the rat polymorphonuclear leukocyte. Science, 157, 318–319

    PubMed  CAS  Google Scholar 

  • Pace-Asciak, C. (1972). Prostaglandin synthetase activity in the rat stomach fundus. Activation by L-norepinephrine and related compounds. Bioehim. Biophys. Acta, 280, 161–171

    CAS  Google Scholar 

  • Pace-Asciak, C. and Wolfe, L. S. (1968). Inhibition of prostaglandin synthesis by oleic, linoleic and linolenic acids. Bioehim. Biophys. Acta, 152, 784–787

    CAS  Google Scholar 

  • Parker, C. W., Huber, M. G. and Baumann, M. L. (1973). Alterations in cyclic AMP metabolism in human bronchial asthma. J. Clin. Invest., 52, 1342–1348

    PubMed  CAS  Google Scholar 

  • Pastan, I. and Katzen, R. (1967). Activation of adenyl cyclase in thyroid homogenates by thyroid-stimulating hormone. Biochem. Biophys. Res. Commun., 29, 792–798

    PubMed  CAS  Google Scholar 

  • Pinckard, R. N., Hawkins, D. and Farr, R. S. (1968). In vitro acetylation of plasma proteins, enzymes and DNA by aspirin. Nature (London), 219, 68–69

    CAS  Google Scholar 

  • Piper, P. J. (1974). Release and metabolism of prostaglandins in lung tissue. Polish J. Pharmacol. Pharm., 26, 61–72

    CAS  Google Scholar 

  • Piper, P. J. and Vane, J. R. (1969). Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature (London), 223, 29–35

    CAS  Google Scholar 

  • Pistorius, E. K. and Axelrod, B. (1974). Iron, an essential component of lipoxygenase. J. Biol. Chem., 249, 3183–3186

    PubMed  CAS  Google Scholar 

  • Quick, J. A. (1966). Salicylates and bleeding: the aspirin tolerance test. Amer. J. Med. Sci., 252, 265–269

    PubMed  CAS  Google Scholar 

  • Ramwell, P. W., Shaw, J. E., Douglas, W. W. and Poisner, A. M. (1966). Efflux of prostaglandin from adrenal glands stimulated with acetylcholine. Nature (London), 210, 273–274

    CAS  Google Scholar 

  • Raz, A., Stern, H. and Kenig-Wakshal, R. (1973). Indomethacin and aspirin inhibition of prostaglandin E2 synthesis by sheep seminal vesicles microsome powder and seminal vesicles slices. Prostaglandins, 3, 337–352

    PubMed  CAS  Google Scholar 

  • Resch, K., Berber, E., Odenthal, J. and Fischer, H. (1971). Early changes in the phospholipid metabolism of lymphocytes following stimulation with phytohemagglutinin and with lysolecithin. Eur. J. Immunol., 1, 162–165

    PubMed  CAS  Google Scholar 

  • Robinson, D R. and Levine, L. (1974). Prostaglandin concentrations in synovial fluid in rheumatic diseases: action of indomethacin and aspirin. In Prostaglandin Synthetase Inhibitors (H. J. Robinson and J. R. Vane, editors), 223–228 (New York: Raven Press)

    Google Scholar 

  • Rome, L. H. and Lands, W. E. M. (1975a). Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs. Proc. Nat. Acad. Sci. (USA), 72, December

    Google Scholar 

  • Rome, L. H. and Lands, W. E. M. (1975b). Properties of a partially-purified preparation of the prostaglandin-forming oxygenase from sheep vesicular gland. Prostaglandins, 10, November

    Google Scholar 

  • Rosenberg, F. J., Gimber-Phillips, P. E., Groblewski, G. E., Davison, C., Phillips, D. K., Goralnick, S. J. and Cahill, E. D. (1971). Acetylsalicylic acid: inhibition of platelet aggregation in the rabbit. J. Pharm. Exp. Ther., 179, 410–418

    CAS  Google Scholar 

  • Rossi, E. C. and Levin, N. W. (1973). Inhibition of ADP-induced platelet aggregation by furosemide. J. Lab. Clin. Med., 81, 140–147

    PubMed  CAS  Google Scholar 

  • Roth, G. J. and Majerus, P. W. (1975). The mechanism of the effect of aspirin on human platelets. J. Clin. Invest., 56, 624–632

    PubMed  CAS  Google Scholar 

  • Roth, G. J., Stanford, N. and Majerus, P. W. (1975). Acetylation of prostaglandin synthetase by aspirin. Proc. Nat. Acad. Sci. (USA), 72, 3073–3076

    CAS  Google Scholar 

  • Rowland, M. and Riegelman, S. (1968). Pharmacokinetics of acetylsalicylic acid and salicylic acid after intravenous administration in man. J. Pharm. Sci., 57, 1313–1319

    CAS  Google Scholar 

  • Said, S. I., Yoshida, T., Kitamura, S. and Vreim, C. (1974). Pulmonary alveolar hypoxia: release of prostaglandins and other humoral mediators. Science, 185, 1181–1183

    PubMed  CAS  Google Scholar 

  • Samuelsson, B. and Hamberg, M. (1974). Role of endoperoxides in the biosynthesis and action of prostaglandins. In: Prostaglandin Synthesis Inhibitors (H. J. Robinson and J. R. Vane, editors), 107–119 (New York: Raven Press)

    Google Scholar 

  • Sato, S., Szabo, M., Kowalski, K. and Burke, G. (1972). Role of prostaglandin in thyrotropin action on thyroid. Endocrinol., 90, 343–356

    CAS  Google Scholar 

  • Scarpa, A. and Azzi, A. (1968). Cation binding to submitochondrial particles. Biochim. Biophys. Acta, 150, 473–481

    PubMed  CAS  Google Scholar 

  • Scarpa, A. and Lindsay, J. G. (1972). Maintenance of energy-linked functions in rat-liver mitochondria aged in the presence of nupercaine. Eur. J. Biochem., 27, 401–407

    PubMed  CAS  Google Scholar 

  • Scherphof, G. L., Scarpa, A. and van Toorenbergen, A. (1972). The effect of local anesthetics on the hydrolysis of free and membrane-bound phospholipids catalyzed by various phospholipases. Biochim. Biophys. Acta, 270, 226–240

    PubMed  CAS  Google Scholar 

  • Schoene, N. W. and Iacono, J. M. (1975). Stimulation of platelet phospholipase A2 activity by aggregating agents. Fed. Proc. (Fed. Amer. Soc. Exp. Biol.), 34, 257

    Google Scholar 

  • Selinger, Z., Batzri, S., Eimerl, S. and Schramm, M. (1973). Calcium and energy requirements for K+ release mediated by the epinephrine α-receptor in rat parotid slices. J. Biol. Chem., 248, 369–372

    PubMed  CAS  Google Scholar 

  • Selinger, Z., Eimerl, S. and Schramm, M. (1974). A calcium ionophore simulating the action of epinephrine on the α-adrenergic receptor. Proc. Nat. Acad. Sci. U.S.A., 71, 128–131

    CAS  Google Scholar 

  • Seppälä, A. J., Saris, N.-E. L. and Gauffin, M. L. (1971). Inhibition of phospholipase A-induced swelling of mitochondria by local anesthetics and related agents. Biochem. Pharmacol., 20, 305–313

    PubMed  Google Scholar 

  • Sharma, S. C. and Fitzpatrick, R. J. (1974). Effect of oestradiol-17β and oxytocin treatment on prostaglandin F alpha release in the anoestrous ewe. Prostaglandins, 6, 97–105

    PubMed  CAS  Google Scholar 

  • Shen, T. Y. (1965). Synthesis and biological activity of some indomethacin analogs. In Non Steroidal Anti-inflammatory Drugs (S. Garattini and M. N. G. Dukes, editors), 13–20 (Amsterdam: Exerpta Medica Foundation)

    Google Scholar 

  • Shen, T. Y., Ham, E. A., Cirillo, V. J. and Zanetti, M. (1974). Structure-activity relationship of certain prostaglandin synthetase inhibitors. In Prostaglandin Synthetase Inhibitors (H. J. Robinson and J. R. Vane, editors), 19–31 (New York: Raven Press)

    Google Scholar 

  • Sih, C. J., Takeguchi, C. and Foss, P. (1970). Mechanism of prostaglandin biosynthesis. III. Catecholamines and serotonin as co-enzymes. J. Amer. Chem. Soc., 92, 6670

    CAS  Google Scholar 

  • Silver, M. J., Smith, J. B., Ingerman, C., and Kocsis, J. J. (1973). Arachidonic acid-induced human platelet aggregation and prostaglandin formation. Prostaglandins, 4, 863–875

    PubMed  CAS  Google Scholar 

  • Smith, A. D. and Winkler, H. (1968). Lysosomal phospholipases A1 and A2 of bovine adrenal medulla. Biochem. J., 108, 867–874

    PubMed  CAS  Google Scholar 

  • Smith, J. B. and Willis, A. L. (1971). Aspirin selectivity inhibits prostaglandin production in human platelets. Nature New Biol., 231, 235–237

    PubMed  CAS  Google Scholar 

  • Smith, J. B., Ingerman, C., Kocsis, J. J. and Silver, M. J. (1973). Formation of prostaglandins during the aggregation of human blood platelets. J. Clin. Invest., 52, 965–969

    PubMed  CAS  Google Scholar 

  • Smith, J. B., Ingerman, C., Kocsis, J. J. and Silver, M. J. (1974). Formation of an intermediate in prostaglandin biosynthesis and its association with the platelet release reaction. J. Clin. Invest., 53, 1468–1473

    PubMed  CAS  Google Scholar 

  • Smith, W. L. and Lands, W. E. M. (1970). The self-catalyzed destruction of lipoxygenase. Biochem. Biophys. Res. Commun., 41, 846–851

    PubMed  CAS  Google Scholar 

  • Smith, W. L. and Lands, W. E. M. (1971). Stimulation and blockade of prostaglandin biosynthesis. J. Biol. Chem, 246, 6700–6704

    PubMed  CAS  Google Scholar 

  • Smith, W. L. and Lands, W. E. M. (1972a). Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular gland. Biochemistry, 11, 3276–3285

    PubMed  CAS  Google Scholar 

  • Smith, W. L. and Lands, W. E. M. (1972b). Oxygenation of unsaturated fatty acids by soybean lipoxygenase. J. Biol. Chem., 247, 1038–1047

    PubMed  CAS  Google Scholar 

  • Sorrentino, L., Capasso, F. and DiRosa, M. (1972). Indomethacin and prostaglandins. Eur. J. Pharmacol., 17, 306–308

    PubMed  CAS  Google Scholar 

  • Stefanovich, V. (1974). Inhibition of 3′,5′-cyclic AMP phosphodiesterase with anti-inflammatory agents. Res. Comm. in Chem. Pathol. and Pharmacol., 7, 573–582

    CAS  Google Scholar 

  • Steinberg, D., Vaughan, M., Nestel, P. J., Strand, O. and Bergström, S. (1964). Effects of the prostaglandins on hormone-induced mobilization of free fatty acids. J. Clin. Invest., 43, 1533–1540

    PubMed  CAS  Google Scholar 

  • Stoffel, W and Trabert, U. (1969). Studies on the occurrence and properties of lysosomal phospholipases A1 and A2 and the degradation of phosphatidic acid in rat liver lyso-somes. Hoppe-Seyler’s Z. Physiol. Chem., 350, 836–844

    PubMed  CAS  Google Scholar 

  • Stossel, T. P., Pollard, T. D., Mason, R. J. and Vaughan, M. (1971). Isolation and properties of phagocytic vesicles from polymorphonuclear leukocytes. J. Clin. Ivest., 50, 1745–1747

    CAS  Google Scholar 

  • Sykes, J. A. C. and Maddox, I. S. (1972). Prostaglandin production by experimental tumours and effects of anti-inflammatory compounds. Nature (New Biol.), 237, 59–61

    CAS  Google Scholar 

  • Szego, C. M. (1972). The role of cyclic AMP in lyosome mobilization and their nucleotropic translocation in steroid hormonal target cells. In Advances in Cyclic Nucleotide Research (P. Greengard and G. L. Robinson, editors), 541–564 (New York: Raven Press)

    Google Scholar 

  • Takeguchi, C., Kohno, E. and Sih, C. J. (1971). Mechanism of prostaglandin biosynthesis. I. Characterization and assay of bovine prostaglandin synthetase. Biochemistry, 10, 2372–2376

    PubMed  CAS  Google Scholar 

  • Takeguchi, C. and Sih, C. J. (1972). A rapid spectrophotometric assay for prostaglandin synthetase: application to the study of non-steroidal anti-inflammatory agents. Prostaglandins, 2, 169–184

    PubMed  CAS  Google Scholar 

  • Tan, W. C. and Privett, O. S. (1973). Studies on the synthesis of prostaglandins in the vesicular glands of essential fatty acid-deficient and hypophysectomized rats. Biochim. Biophys. Acta, 296, 586–592

    PubMed  CAS  Google Scholar 

  • Tappel, A. L. (1963). Lipoxidase. In The Enzymes (P. D. Boyer, H. Lardy and K. Myrback, editors), vol. 8, 275–283 (New York: Academic Press)

    Google Scholar 

  • Tappel, A. L., Boyer, P. D. and Lundberg, W. O. (1952). The reaction mechanism of soy bean lipoxidase. J. Biol. Chem., 199, 267–281

    PubMed  CAS  Google Scholar 

  • Tobian, L. (1974). How sodium and the kidney relate to the hypertensive arteriole Fed. Proc. (Fed. Amer. Soc. Exp. Biol.), 33, 138–142

    CAS  Google Scholar 

  • Tomlinson, R. V., Ringold, H. J., Qureshi, M. C. and Forchielli, E. (1972). Relationship between inhibition of prostaglandin synthesis and drug efficacy: support for the current theory on mode of action of aspirin-like drugs. Biochem. Biophys. Res. Commun., 46, 552–559

    PubMed  CAS  Google Scholar 

  • Vanderhoek, J. Y. and Lands, W. E. M. (1973a). Acetylenic inhibitors of sheep vesicular gland oxygenase. Biochim. Biophys. Acta, 296, 374–381

    PubMed  CAS  Google Scholar 

  • Vanderhoek, J. Y. and Lands, W. E. M. (1973b). The inhibition of the fatty acid oxygenase of sheep vesicular gland by antioxidants. Biochim. Biophys. Acta, 296, 382–385

    PubMed  CAS  Google Scholar 

  • Van Dorp, D. A. (1967). Aspects of the biosynthesis of prostaglandins. In Progress in Biochemical Pharmacology (D. Kritchevsky, R. Paoletti and D. Steinberg, editors), vol. 3, 71–82 (New York: S. Karger)

    Google Scholar 

  • Van Dorp, D. A. (1974). Essential fatty acids and prostaglandins, XXIVth Int. Congress of Pure and Applied Chemistry, 2, 117

    Google Scholar 

  • Vane, J. R. (1971). Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (New Biol.), 231, 232–235

    CAS  Google Scholar 

  • van Golde, L. M. G., Fleischer, B. and Fleischer, S. (1971). Some studies on the metabolism of phospholipids in Golgi complex from bovine and rat liver in comparison to other subcellular fractions. Biochim. Biophys. Acta, 249, 318–330

    PubMed  Google Scholar 

  • van Praag, D., Farber, S. J. and Prose, P. H. (1973). The effect of increased osmolality on the metabolism of PGE in rabbit kidney. Proc. Int. Congr. Biochem., Stockholm, 339

    Google Scholar 

  • Vargaftig, B. B. (1966). Effet des analgesiques non narcotiques sur l’hypotension due à la bradykinine. Experientia (Basel), 22, 182–183

    CAS  Google Scholar 

  • Vargaftig, B. B. (1973). The pharmacology of slow reacting substance C and of arachidpnic acid. Agents and Actions, 3, 357–365

    PubMed  CAS  Google Scholar 

  • Vargaftig, B. B. and Coiron, M. (1971). Detection de la phospholipase a de divers venins animaux par ses effets la coagulation du jaune d’oeuf et par la formation de ‘substance a contraction differee C’. J. Pharmacol. (Paris), 2, 155–174

    Google Scholar 

  • Vargaftig, B. B. and Dao, N. (1970). Antagonism by anti-inflammatory drugs of tissue slow reacting substance C. Pharmacol. Res. Commun., 2, 149–157

    CAS  Google Scholar 

  • Vargaftig, B. B. and Dao, H. N. (1971). Mode d’action met antagonisme de la ‘substance a contraction differee C liberee par la phospholipase A, a partir du jaune d’oeuf. J. Pharmacol. (Paris), 2, 287–304

    Google Scholar 

  • Vargaftig, B. B. and Dao Hai, N. (1972). Interference of some thiol derivatives with the pharmacological effects of arachidonic acid and slow reacting substance C and with the release of rabbit aorta contracting substances. Eur. J. Pharm., 18, 43–55

    CAS  Google Scholar 

  • Velo, G. P., Dunn, C. J., Giroud, J. P., Timsit, J. and Willoughby, D. A. (1973). Distribution of prostaglandins in inflammatory exudate. J. Path., 111, 149–158

    PubMed  CAS  Google Scholar 

  • Victoria, E. J., van Golde, L. M. G., Hostetier, K. Y., Scherphof, G. L. and van Deenen, L. L. M. (1971). Some studies on the metabolism of phospholipids in plasma membranes from rat liver. Biochim. Biophys. Acta, 239, 443–457

    CAS  Google Scholar 

  • Vogt, W. (1957). Pharmacologically active substances formed in egg yolk by cobra venom. J. Physiol. (London), 136, 131–147

    CAS  Google Scholar 

  • Vogt, W., Meyer, U., Kunze, H., Lufft, E. and Babilli, S. (1969). Entstehung von SRS-C in der durchstromten Meerschweinchenlunge durch Phospholipase A. Arch. Pharm. Exp. Path., 262, 124–134

    CAS  Google Scholar 

  • Vonkeman, H. and Van Dorp, D. A. (1968). The action of prostaglandin synthetase on 2-arachidonyl-lecithin. Biochim. Biophys. Acta, 164, 430–432

    PubMed  CAS  Google Scholar 

  • Waite, M., Scherphof, G. L., Boshouwers, F. M. G. and van Deenen, L. L. M., (1969). Differentiation of phospholipases A in mitochondria and lysosomes of rat liver. J. Lipid Res., 10, 411–420

    PubMed  CAS  Google Scholar 

  • Waite, M. and Sisson, P. (1972). Effect of local anesthetics on phospholipases from mitochondria and lysosomes. A probe into the role of the calcium ion in phospholipid hydrolysis. Biochemistry, 11, 3098–3105

    PubMed  CAS  Google Scholar 

  • Wallach, D. P. and Daniels, E. G. (1971). Properties of a novel preparation of prostaglandin synthetase from sheep seminal vesicles. Biochim. Biophys. Acta, 231, 445–457

    PubMed  CAS  Google Scholar 

  • Weglicki, W. B., Ruth, R. C., Owens, K., Griffin, H. D. and Waite, B. M. (1974). Changes in lipid composition of triton-filled lysosomes during lysis. Biochim. Biophys. Acta, 337, 145–152

    PubMed  CAS  Google Scholar 

  • Weissmann, G., Zurier, R. B. and Hoffstein, S. (1973). Leukocytes as secretory organs of inflammation. Agents and Actions, 3, 370–379

    PubMed  CAS  Google Scholar 

  • Whitehouse, M. W. and Famaey, J. P. (1973). Concerning the pharmacological activity of non-steroid anti-inflammatory drugs. Is the acidic function essential ? Agents and Actions, 3, 217–220

    PubMed  CAS  Google Scholar 

  • Willis, A. L. (1974). An enzymatic mechanism for the anti-thrombotic and anti-hemostatic actions of aspirin. Science, 183, 325–327

    PubMed  CAS  Google Scholar 

  • Willis, A. L., Vane, F. ML, Kuhn, D. C., Scott, C. G. and Petrin, M. (1974). An endoperoxide aggregator (LASS), formed in platelets in response to thrombotic stimuli. Prostaglandins, 8, 453–507

    PubMed  CAS  Google Scholar 

  • Willis, A. L. and Weiss, H. J. (1973). A congenital defect in platelet prostaglandin production associated with impaired hemostatis in storage pool disease. Prostaglandins, 4, 783–794

    PubMed  CAS  Google Scholar 

  • Wilson, H., Spargo, B. and Getz, G. S. (1973a). Changes in kidney medullary phospholipid metabolism in the potassium-deficient rat. Amer. J. Path., 71, 295–314

    PubMed  CAS  Google Scholar 

  • Wilson, H., Spargo, B. and Getz, G. S. (1973b). Changes in kidney medullary phospholipid metabolism in the potassium-depleted rat. Amer. J. Path., 71, 315–330

    PubMed  CAS  Google Scholar 

  • Wojtczak, L. and Lehninger, A. L. (1971) Formation and disappearance of an endogenous uncoupling factor during swelling and contraction of mitochondria Biochim. Biophys. Acta, 51, 442–456

    Google Scholar 

  • Wolff, J. and Moore, W. V. (1973). The effect of indomethacin on the response of thyroid tissue to thyrotropin. Biochem. Biophys. Res. Commun., 51, 34–39

    PubMed  CAS  Google Scholar 

  • Yoshimoto, A., Ito, H. and Tomita, K. (1970). Cofactor requirements of the enzyme synthesizing prostaglandin in bovine seminal vesicles. J. Biochem. (Tokyo), 68, 487–499

    CAS  Google Scholar 

  • Ziboh, V. A. (1973). Biosynthesis of prostaglandin E2 in human skin: subcellular localization and inhibition by unsaturated fatty acids and anti-inflammatory drugs. J. Lipid Res., 14, 377–384

    PubMed  CAS  Google Scholar 

  • Ziboh, V. A., Vanderhoek, J. Y. and Lands, W. E. M. (1974). Inhibition of sheep vesicular gland oxygenase by unsaturated fatty acids from skin of essential fatty acid deficient rats. Prostaglandins, 5, 233–240

    PubMed  CAS  Google Scholar 

  • Zurier, R. B., Dukor, P. and Weissmann, G. (1971). Effect of cyclic AMP and colchicine on hydrolase release from phagocytes. Clin. Res., 19, 453

    Google Scholar 

  • Zurier, R. B., Cosgrove, J. M. and Hinz, C. F. Jr. (1975). Enhancement by cyclic AMP (cAMP) and prostaglandin El (PGE1) of cytotoxicity mediated by human monocytes. Fed. Proc. (Fed. Amer. Soc. Exp. Biol.), 34, 1029

    Google Scholar 

  • Zurier, R. B., Hoffstein, S. and Weissmann, G. (1973). Mechanisms of lysosomal enzyme release from human leukocytes. I. Effect of cyclic nucleotides and colchicine. J. Cell. Biol., 58, 27–41

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. W. E. M. Lands
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. H. Rome
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynaecology, University of Singapore, Kandang Kerbau Hospital, Hampshire Road, Singapore 8, Republic of Singapore

    S. M. M. Karim (Research Professor of Obstetrics and Gynaecology) (Research Professor of Obstetrics and Gynaecology)

Rights and permissions

Reprints and permissions

Copyright information

© 1976 MTP Press Ltd

About this chapter

Cite this chapter

Lands, W.E.M., Rome, L.H. (1976). Inhibition of Prostaglandin Biosynthesis. In: Karim, S.M.M. (eds) Prostaglandins: Chemical and Biochemical Aspects. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-9648-2_3

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-9648-2_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-9650-5

  • Online ISBN: 978-94-011-9648-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation