Brain pp 324-329 | Cite as

Postnatal Maturation of the Local Cerebral Circulation

  • Louis Sokoloff


In most mammals, especially primates, the brain is highly underdeveloped and relatively undifferentiated at birth, and a major portion of its anatomical, chemical, and functional differentiation is achieved postnatally early in its extrauterine life. It is to be expected that changes in the cerebral circulation accompany and reflect the maturational and developmental processes. Since periods of rapid change are generally quite vulnerable to all sorts of noxious influences, it can further be assumed that there are pathologic conditions which are associated with and, perhaps, even consequences of aberrations in the pattern of development of the cerebral circulation. In order to establish the normal pattern of postnatal development of the cerebral circulation, local blood flow of the individual structures of the brain was studied as a function of postnatal age.


Blood Flow White Matter Gray Matter Cerebral Blood Flow Cerebral Circulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Freygang, W.H. and Sokoloff, L.: Quantitative measurements of regional circulation in the central nervous system by the use of radioactive inert gas. Adv. biol. med. Physics 6: 263–279 (1958).Google Scholar
  2. Himwich, H.E. and Fazekas, J.F.: Comparative studies of the metabolism of the brain of infant and adult dogs. Am. J. Physiol. 132: 454–459 (1941).Google Scholar
  3. Kennedy, C., Grave, G.D., Jehle, J.W. and Sokoloff, L.: Blood flow to white matter during maturation of the brain. Neurology 20: 613–618 (1970).PubMedGoogle Scholar
  4. Kennedy, C., Grave, G.D., Jehle, J.W. and Sokoloff, L.: Changes in blood flow in the component structures of the dog brain during postnatal maturation. J. Neurochem. 19: 2423–2433 (1972).PubMedCrossRefGoogle Scholar
  5. Kennedy, C. and Sokoloff, L.: An adaptation of the nitrous oxide method to the study of the cerebral circulation in children; normal values for cerebral blood flow and cerebral metabolic rate in childhood. J. clin. Invest. 36: 1130–1137 (1957).PubMedCrossRefGoogle Scholar
  6. Kety, S.S.: Measurement of local blood flow by the exchange of an inert, diffusible substance; in Bruner, Methods in Medical Research. Vol. VIII, pp. 228–236 ( Year Book Publishers, Chicago 1960 ).Google Scholar
  7. Landau, W.M., Freygang, W.H., Rowland, L.P., Sokoloff. L. and Kety, S.S.: The local circulation of the living brain; values in the unanesthetized and anesthetized cat. Trans. Am. neurol. Ass. 80: 125–129 (1955).Google Scholar
  8. Reivich. M., Jehle, J.W., Sokoloff, L. and Kety, S.S.: Measurement of regional cerebral blood flow with “C-antipyrine in awake cats. J. appl. Physiol. 27: 296–300 (1969).PubMedGoogle Scholar
  9. Sokoloff, L.: Local cerebral circulation at rest and during altered cerebral activity induced by anesthesia or visual stimulation; in Kety and Elkes, The Regional Chemistry. Physiology and Pharmacology of the Nervous System. pp. 107–117 ( Pergamon Press, Oxford 1961 ).Google Scholar

Copyright information

© Martinus Nijhoff, The Hague, Netherlands 1977

Authors and Affiliations

  • Louis Sokoloff

There are no affiliations available

Personalised recommendations