Brain pp 316-323 | Cite as

Metabolic Aspects of Cerebral Anoxia in the Fetus and Newborn

  • Thomas E. Duffy
  • Robert C. Vannucci


Developing animals tolerate anoxia and asphyxia better than adults, and fetuses are more resistant than newborns (Glass et al., 1944; Dawes et al., 1959; Duffy et al., 1975). The greater resistance of the immature cardiovascular system partly accounts for this decreased vulnerability, but the resistance of the developing nervous system seems to be the major determinant of anoxic morbidity and mortality. The greater susceptibility of the nervous system, compared to the heart, is emphasized by the fact that when newborn dogs or rats are exposed to an atmosphere of nitrogen, the heart continues to beat long after respiratory movements cease (Fazekas et al., 1941; Swann et al., 1954; Adolph, 1974), implying loss of central respiratory control prior to circulatory failure.


Respiratory Arrest Anaerobic Glycolysis Metabolic Aspect Glycolytic Capacity Cerebral Anoxia 
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Copyright information

© Martinus Nijhoff, The Hague, Netherlands 1977

Authors and Affiliations

  • Thomas E. Duffy
  • Robert C. Vannucci

There are no affiliations available

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