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Pathophysiologic Basis for the Selective Vulnerability of the Immature Rat Brain to Seizures

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Brain

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Abstract

Seizures too mild to damage the adult rat brain irreversibly impair brain development when they occur during vulnerable periods (Wasterlain & Plum, 1973; Wasterlain 1976a, 1976b; Nealis et al., 1976). We are just beginning to understand the biochemical basis for this selective vulnerability of the developing brain. This understanding is of more than academic interest since we now know that development of the human brain is predominantly post-natal (Dobbing & Sands, 1973), and elucidation of pathophysiologic mechanisms offers important clues for therapy of neonatal seizures.

Supported by NIN CDS Research Grant NS 13515 and by the Research Service of the Veterans Administration.

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Authors
  1. Claude G. Wasterlain M.D.
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  2. Thomas E. Duffy Ph.D.
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Editor information

Samuel R. Berenberg M.D.

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© 1977 Martinus Nijhoff, The Hague, Netherlands

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Wasterlain, C.G., Duffy, T.E. (1977). Pathophysiologic Basis for the Selective Vulnerability of the Immature Rat Brain to Seizures. In: Berenberg, S.R. (eds) Brain. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-8884-5_19

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  • DOI: https://doi.org/10.1007/978-94-011-8884-5_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-8221-8

  • Online ISBN: 978-94-011-8884-5

  • eBook Packages: Springer Book Archive

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