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Brain pp 213-223 | Cite as

Viral Infections and Brain Development

  • Richard T. Johnson

Abstract

The extraordinary diversity of cerebral lesions that can be induced by viruses is explicable primarily by two basic principles: 1) varied cell populations of the central nervous system have different susceptibility to different viruses and, 2) viral infections can have varied effects on cells. During development the complexity of these virus-host interrelationships are compounded by changes in the cell susceptibility and response attendant on cell generation, migration, and differentiation; and by the simultaneous maturation of humoral and cellmediated immune systems in the fetus and newborn which may modify the infectious process.

Keywords

Neural Tube Newcastle Disease Virus Bovine Viral Diarrhea Virus Ependymal Cell Bovine Viral Diarrhea 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Anderson, A.A. and Hanson, R.P.: Intrauterine infection of mice with St. Louis encephalitis virus: immunological, physiological, neurological and behavioral effects on progeny. Infect. Immun. 12: 1173–1183 (1975).Google Scholar
  2. 2.
    Barlow, R.M., Gardiner, A.C., Storey, I.J. and Slater, J.S.: Experiments in Border disease. II. Some aspects of the disease in the foetus. J. Comp. Path. 80: 635–643 (1970).PubMedCrossRefGoogle Scholar
  3. 3.
    Becker. L.E., Narayan, O. and Johnson, R.T.: Comparative studies of viral infections of the developing forebrain. 1. Pathogenesis of rat virus and bluetongue vaccine virus infections in neonatal hamsters. J. Neuropath. Exp. Neurol. 33: 519–529 (1974).PubMedCrossRefGoogle Scholar
  4. 4.
    Bray, P.F.: Mumps - a cause of hydrocephalus? Pediat. 49: 446. 449 (1972).Google Scholar
  5. 5.
    Brown, T.T., deLahunta, A., Bistner, S.I., Scott, K.W. and McEntee, K.: Pathogenetic studies of infection of the bovine fetus with bovine viral diarrhea virus. I. Cerebellar atrophy. Vet. Path. 1 1: 486–505 (1974).Google Scholar
  6. 6.
    Coffey, V.P. and Jessop, W.J.E.: Maternal influenza and congenital deformities. Lancet 1: 748–751 (1963).PubMedCrossRefGoogle Scholar
  7. 7.
    Copps, S.C. and Giddings, L.E.: Transplacental transmission of western equine encephalitis. Pediatrics 24: 31–33 (1959).PubMedGoogle Scholar
  8. 8.
    Davis, L.E., Shurin, S. and Johnson, R.T.: Experimental viral labyrinthitis. Nature 254: 329331 (1975).Google Scholar
  9. 9.
    Davis, L.E. and Johnson, R.T.: Experimental viral infections of the inner ear. I. Acute infections of the newborn hamster labyrinth. Lab. Invest. 34: 349–356 (1976).PubMedGoogle Scholar
  10. 10.
    Desmond, M.M., Wilson, G.S., Melnick, J.L., Singer, D.B., Zion, T.E., Rudolph, A.J., Pineda, R.G., Ziai, M.H. and Blattner, R.J.: Congenital rubella encephalitis. J. Pediat. 71: 311–331 (1967).PubMedCrossRefGoogle Scholar
  11. 11.
    Emerson, J.L. and Delez, A.L.: Cerebellar hypoplasia, hypomyelinogenesis and congenital tremors in pigs, associated with prenatal hog cholera vaccination of sows. J. Amer. Vet. Med. Assoc. 147: 47–54 (1967).Google Scholar
  12. 12.
    Ennis, F.A., Hopps, H.E., Douglas, R.D. and Meyer, H. M., Jr.: Hydrocephalus in hamsters: induction by natural and attenuated mumps viruses. J. Inf. Dis. 119: 75–79 (1969).CrossRefGoogle Scholar
  13. 13.
    Florman, A.L., Gershon, A.A., Blackett, P.R. and Nahmias, A.J.: Intrauterine infection with herpes simplex virus. Resultant congenital malformations. J.A.M.A. 225: 129–132 (1973).PubMedCrossRefGoogle Scholar
  14. 14.
    Friedman, H.M., Gilden, D.H., Lief, F.S., Rorke, L.B., Santoli, D. and Koprowski, H.: Hydrocephalus produced by the 6;94 virus. Arch. Neurol. 32: 408–413 (1975).PubMedCrossRefGoogle Scholar
  15. 15.
    Gear, J.H.S. and Measroch, V.: Coxsackie virus infections of the newborn. Prog. Med. Virol. 15: 42–62, 1973.PubMedGoogle Scholar
  16. 16.
    Gilden, D.H., Friedman, H. M. and Nathanson, N.: Tamiami virus induced cerebellar heterotopia. J. Neuropath. Exp. Neurol. 33: 29–41 (1974).PubMedCrossRefGoogle Scholar
  17. 17.
    Hakosalo, J. and Saxen, L.: Influenza epidemic and congenital defects. Lancet 2: 1346–1347 (1971).PubMedCrossRefGoogle Scholar
  18. 18.
    Hamburger, V. and Habel, K.: Teratogenetic and lethal effects of influenza-A and mumps viruses on early chick embryos. Proc. Soc. Exp. Biol. 66: 608–617 (1947).PubMedGoogle Scholar
  19. 19.
    Hanshaw, J.B.: Congenital cytomegalovirus infection: a fifteen year perspective. J. Inf. Dis. 123: 555–561 (1971).CrossRefGoogle Scholar
  20. 20.
    Hanshaw, J.B., Scheiner, A.P., Moxley, A.W., Gaev. L., Abel, V. and Scheiner. B.: School failure and deafness after “Silent’ congenital cytomegalovirus infection. New Eng. J. Med. 295: 468–470 (1976).CrossRefGoogle Scholar
  21. 21.
    Hanshaw, J.B.: Herpesvirus hominis infections in the fetus and the newborn. Am. J. Dis. Child. 126: 546–555 (1973).PubMedGoogle Scholar
  22. 22.
    Hardy, J.B.: Fetal consequences of maternal viral infections in pregnancy. Arch. Otolaryngol. 98: 218–227 (1973a).PubMedCrossRefGoogle Scholar
  23. 23.
    Hardy, J.B.: Clinical and developmental aspects of congenital rubella. Arch. Otolaryngol. 98: 230–236 (19736).Google Scholar
  24. 24.
    Haspel, M.V. and Rapp, F.: Measles virus: an unwanted variant causing hydrocephalus. Science 187: 450–451 (1975).PubMedCrossRefGoogle Scholar
  25. 25.
    Herndon, R.M., Johnson, R.T., Davis, L.E. and Descalzi, L.R.: Ependymitis in mumps virus meningitis. Electron microscopical studies of cerebrospinal fluid. Arch. Neurol. 30: 475–479 (1974).PubMedCrossRefGoogle Scholar
  26. 26.
    Hower, J., Clar, H.E. and Duchting, M.: Aquaduckt verschluss nach Mumps-Meningitis. Dtsch. med. Wschr. 97: 43–44 (1972).CrossRefGoogle Scholar
  27. 27.
    Howell, P.G. and Verwoerd, D.W.: Bluetongue virus. Virol. Mono. 9: 35–74 (1971).Google Scholar
  28. 28.
    Johnson, K.P., Ferguson, L.C., Byington, D.P. and Redman, D.: Multiple fetal malformations due to persistent viral infection. I. Abortion, intra-uterine death and gross abnormalities in fetal swine infected with hog cholera vaccine virus. Lab. Invest. 30: 608–617 (1974).PubMedGoogle Scholar
  29. 29.
    Johnson, K.P., Klasnja, R. and Johnson, R.T.: Neural tube defects of chick embryos: an indirect result of influenza A virus infection. J. Neuropath. Exp. Neurol. 30: 68–74 (1971).PubMedCrossRefGoogle Scholar
  30. 30.
    Johnson, R.T.: Effects of viral infections on the developing nervous system. New Eng. J. Med. 287: 599–604 (1972).CrossRefGoogle Scholar
  31. 31.
    Johnson, R.T.: Hydrocephalus and viral infections. Develop. Med. Child. Neurol. 17: 807–816 (1975).PubMedCrossRefGoogle Scholar
  32. 32.
    Johnson, R.T.: The teratogenic effect of viruses; in Vinken and Bruyn, Handbook of Clinical Neurology, Vol. 33 (North Holland Publishing Co., Amsterdam, in press).Google Scholar
  33. 33.
    Johnson, R.T. and Johnson, K.P.: Hydrocephalus following viral infection: the pathology of aqueductal stenosis developing after experimental mumps virus infection. J. Neuropath. Exp. Neurol. 27: 591–606 (1968).PubMedCrossRefGoogle Scholar
  34. 34.
    Johnson, R.T. and Johnson, K.P.: Hydrocephalus as a sequela of experimental myxovirus infections. Exp. Molec. Path. 10: 68–80 (1969).PubMedCrossRefGoogle Scholar
  35. 35.
    Johnson, R.T., Johnson, K.P. and Edmonds, C.J.: Virus-induced hydrocephalus: development of aqueductal stenosis in hamsters after mumps infection. Science 157: 1066–1067 (1967).PubMedCrossRefGoogle Scholar
  36. 36.
    Kilham, L. and Margolis, G.: Cerebellar ataxia in hamsters inoculated with rat virus. Science 143: 1047–1048 (1964).PubMedCrossRefGoogle Scholar
  37. 37.
    Kilham, L. and Margolis, G.: Cerebellar disease in cats induced by inoculation of rat virus. Science 148: 244–246 (1965).PubMedCrossRefGoogle Scholar
  38. 38.
    Kilham, L. and Margolis, G.: Viral etiology of spontaneous ataxia of cats. Amer. J. Path. 48: 991–1011 (1966).PubMedGoogle Scholar
  39. 39.
    Kilham, L. and Margolis, G.: Spontaneous hepatitis and cerebellar “hypoplasia” in suckling rats due to congenital infections with rat virus. Amer. J. Path. 49: 457–475 (1966).PubMedGoogle Scholar
  40. 40.
    Kilham, L. and Margolis, G.: Hydrocephalus in hamsters, ferrets, rats and mice following inoculations of reovirus type I. I. Virologie studies. Lab. Invest. 21: 183–188 (1969).Google Scholar
  41. 41.
    Kilham, L. and Margolis, G.: Pathogenicity of minute virus of mice (MVM) for rats, mice and hamsters. Proc. Soc. Exp. Biol. 133: 1447–1452 (1970).PubMedGoogle Scholar
  42. 42.
    Kilham, L. and Margolis, G.: Induction of congenital hydrocephalus in hamsters with attenuated and natural strains of mumps virus. J. Inf. Dis. 132: 462–466 (1975).CrossRefGoogle Scholar
  43. 43.
    Kurogi, H., Inaba, Y., Goto, Y., Miura, Y., Takahashi, H., Sato, K., Omori, T. and Matumoto, M.: Serologic evidence for etiologic role of Akabane virus in epizootic abortion-arthrogryposis-hydranencephaly in cattle in Japan, 1972–1974, Arch. Virol. 47: 71–83 (1975).Google Scholar
  44. 44.
    London, W.T., Fuccillo, D.A., Sever, J.L. and Kent, S.G.: Influenza virus as a teratogen in rhesus monkeys. Nature 255: 483–484 (1975).PubMedCrossRefGoogle Scholar
  45. 45.
    London, W.T. and Sever, J.L.: Personal communication.Google Scholar
  46. 46.
    Margolis, G. and Kilham, L.: Hydrocephalus in hamsters, ferrets, rats and mice following inoculations with reovirus type 1. Il. Pathologic studies. Lab. Invest. 21: 189–198 (1969).PubMedGoogle Scholar
  47. 47.
    Menser, M.A. and Forrest, J.M.: Rubella-high incidence of defects in children considered normal at birth. Med. J. Australia I: 123–126 (1974).Google Scholar
  48. 48.
    Mims, C.A., Murphy, F.A., Taylor, W.P. and Marshall, I.D.: The pathogenesis of Ross River virus infection in mice. 1. Ependymal infection, cortical thinning and hydrocephalus. J. Inf. Dis. 127: 121–128 (1973).CrossRefGoogle Scholar
  49. 49.
    Monjan, A.A., Gilden, D.H., Cole, G.A. and Nathanson, N.: Cerebellar hypoplasia in neonatal rats caused by lymphocytic choriomeningitis virus. Science 171: 194–196 (1970).CrossRefGoogle Scholar
  50. 50.
    Nahmias, A.J., Alford, C.A. and Korones, S.B.: Infection of the newborn with herpesvirus hominis. Adv. Pediat. 17: 185–226, 1970.Google Scholar
  51. 51.
    Narayan, O. and Johnson, R.T.: Effects of viral infection on nervous system development. I. Pathogenesis of bluetongue virus infection in mice. Amer. J. Path. 68: 1–14 (1972).Google Scholar
  52. 52.
    Narayan, O., McFarland, H.F. and Johnson, R.T.: Effects of viral infection on nervous system development. II. Attempts to modify bluetongue virus-induced malformations with cyclophosphamide and antithymocyte serum. Amer. J. Path. 68: 15–22 (1972).PubMedGoogle Scholar
  53. 53.
    Naske, R. and Poustka, K.: Eine seltine Komplikation nach Mumpsmeningoenzephalitis. Wein. Med. Wochenschr. 123: 221–224 (1973).Google Scholar
  54. 54.
    Osburn, B.I., Silverstein, A.M., Prendergast, R.A., Johnson, R.T. and Parshall, C.J.: Experimental viral-induced congenital encephalopathies. I. Pathology of hydranencephaly and porencephaly caused by bluetongue vaccine virus. Lab. Invest. 25: 197–205 (1971).PubMedGoogle Scholar
  55. 55.
    Osburn, B.I., Johnson, R.T., Silverstein, A.M., Prendergast, R.A., Jochim, M.M. and Levy, S.E.: Experimental viral-induced congenital encephalopathies. II. The pathogenesis of blue-tongue vaccine virus infection in fetal lambs. Lab. Invest. 25: 206–210 (1971).PubMedGoogle Scholar
  56. 56.
    Paraicz, E.: Angaben zum membranosen Verschluss des Aqueductus Sylvii. Acta Paediat. Acad. Sci. Hung. 11: 121–133 (1970).Google Scholar
  57. 57.
    Raine, C.S. and Fields, B.N.: Neurotropic virus-host relationship alterations due to variation in viral genome as studied by electron microscopy. Amer. J. Path. 75: 119–132 (1974).PubMedGoogle Scholar
  58. 58.
    Reynolds, D.W., Stagno, S., Stubbs, G., Dahle, A.J., Livingston, M. M., Saxon, S.S. and Alford, C.A.: Inapparent congenital cytomegalovirus infection with elevated cord IgM levels. Causal relation with auditory and mental deficiency. New Eng. J. Med. 290: 291–296 (1974).CrossRefGoogle Scholar
  59. 59.
    Rinvik, R.: Congenital varicella encephalomyelitis in surviving newborn. Amer. J. Dis. Child. 117: 231–235 (1969).PubMedGoogle Scholar
  60. 60.
    Robertson, G.G., Williamson, A.P. and Blattner, R.J.: A study of abnormalities in early chick embryos inoculated with Newcastle disease virus. J. Exp. Zool. 129: 5–43 (1955).CrossRefGoogle Scholar
  61. 61.
    Robertson, G.G., Williamson, A.P. and Blattner, R.J.: Origin of myeloschisis in chick embryos infected with influenza-A virus. Yale J. Biol. Med. 32: 449–463 (1960).Google Scholar
  62. 62.
    Schultz, G. and Delay, P.D.: Losses in newborn lambs associated with bluetongue vaccination of pregnant ewes. J. Amer. Vet. Med. Assoc. 127: 224–226 (1955).Google Scholar
  63. 63.
    Scott, F.W., Kahrs, R.F., DeLahunta, A., Brown, T.T., McEntee, K. and Gillespie, J.H.: Virus induced congenital anomalies of the bovine fetus. I. Cerebellar degeneration (hypoplasia), ocular lesions and fetal mummification following experimental infection with bovine viral diarrhea-mucosal disease virus. Cornell Vet. 63: 536–560 (1973).PubMedGoogle Scholar
  64. 64.
    Sever, J.L.: Viral teratogens; in Perrin and Finegold, Pathobiology of Development, pp. 97104 ( Williams & Wilkins, Baltimore 1973 ).Google Scholar
  65. 65.
    Shimizu, T., Kawakami, Y., Fukuhara, S. and Matumoto, M.: Experimental stillbirth in pregnant swine infected with Japanese encephalitis virus. Jap. J. Exp. Med. 24: 363–375 (1954).PubMedGoogle Scholar
  66. 66.
    Shinefield, H.R. and Townsend, T.E.: Transplacental transmission of Western equine encephalomyelitis. J. Pediat. 43: 21–25 (1953).PubMedCrossRefGoogle Scholar
  67. 67.
    Siegel, M. and Greenberg, M.: Poliomyelitis in pregnancy: effect on fetus and newborn infant. J. Pediat. 49: 280–288 (1956).PubMedCrossRefGoogle Scholar
  68. 68.
    South, M.A., Tompkins, W.A.F., Morris, C.R. and Rawls, W.E.: Congenital malformation of the central nervous system associated with genital (type 2) herpesvirus. J. Pediat. 75: 13–18 (1969).PubMedCrossRefGoogle Scholar
  69. 69.
    Srabstein, J.C., Morris, N., Larke, R.P.B., de Sa, D.J., Castelino, B.B. and Sum. E.: Is there a congenital varicella syndrome ? J. Pediat. 84: 239–243 (1974).PubMedCrossRefGoogle Scholar
  70. 70.
    Steigman, A.J. quoted by Bray, P.F.: Letter to Editor. Pediatrics 50: 349 (1972).Google Scholar
  71. 71.
    Strauss, M. and Davis, G. L.: Viral disease of the labyrinth. I Review of the literature and discussion of the role of cytomegalovirus in congenital deafness. Ann. Otol. Rhinol. Laryngol. 82: 1–7 (1973).Google Scholar
  72. 72.
    Timmons, G.D. and Johnson, K.P.: Aqueductal stenosis and hydrocephalus after mumps encephalitis. New Eng. J. Med. 283: 1505–1507 (1970).CrossRefGoogle Scholar
  73. 73.
    Ward, G.M.: Experimental infection of pregnant sheep with bovine viral diarrhea–mucosal disease virus. Cornell Vet. 61: 179–191 (1971).PubMedGoogle Scholar
  74. 74.
    Wenger, F.: Necrosis cerebral masiva del feto en casos de encefalitis equina Venezolana. Invest. Clin. 21: 13–31 (1967).Google Scholar
  75. 75.
    Williamson, A.P., lattner, R.J. and Robertson, G.G.: The relationship of viral antigen to virus-induced defects in chick embryos. Newcastle disease virus. Develop. Biol. 12: 498–519 0965 ).Google Scholar
  76. 76.
    Young, S. and Cordy, D.R.: An ovine encephalopathy caused by bluetongue vaccine virus. J. Neuropath. Exp. Neurol. 23: 635–659 (1964).PubMedCrossRefGoogle Scholar

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© Martinus Nijhoff, The Hague, Netherlands 1977

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  • Richard T. Johnson

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