Abstract
Because mammalian organisms are uniformly aerobic and dependent for survival on oxidative metabolic processes, the potential toxic effects of oxygen are often neglected. Nevertheless, as with most substances, natural and otherwise, excessive oxygen has deleterious effects in a variety of tissues including those of the nervous system. It has long been known that high concentrations of oxygen at elevated atmospheric pressure produce seizures (Bean, 1954) and neuronal (Balentine, 1968) and retinal ganglion cell necrosis (Margolis & Brown, 1966). Hyperoxia at normal atmospheric pressure is not known to produce pathologic effects in the mature nervous system, but there is evidence that during periods of rapid maturation and development in perinatal life nervous tissues may be particularly susceptible to toxic effects of oxygen.
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© 1977 Martinus Nijhoff, The Hague, Netherlands
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Sokoloff, L. (1977). Toxic Effects of Elevated Oxygen Tension on Brain Maturation. In: Berenberg, S.R. (eds) Brain. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-8884-5_12
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DOI: https://doi.org/10.1007/978-94-011-8884-5_12
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