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Behavioral Effects of Opiates: A Pharmacogenetic Analysis

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Current Developments in Psychopharmacology

Part of the book series: Current Developments in Psychopharmacology ((CDPS,volume 6))

Abstract

A number of experiments carried out in recent years, have emphasized individual differences in reactivity to many psychotropic agents, both in humans and in laboratory animals. This may be due to differences in the rate of absorption, distribution, metabolism, or excretion of drugs; or to differences in the sensitivity of target systems to compounds acting at the central nervous system (CNS) level.

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References

  • Alleva, E., Castellano, C., and Oliverio, A. (1980). Effects of L- and D-Aminoacids on analgesia and locomotor activity of mice. Their interaction with morphine. Brain Res. 198: 249–252.

    Article  PubMed  CAS  Google Scholar 

  • Blasig, J., Herz, A., Reinhold, K., and Zieglgansberger, S. (1973). Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats. Psychopharmacologia. 33: 19–38.

    Article  PubMed  CAS  Google Scholar 

  • Bovet, D., Bovet-Nitti, F., and Oliverio, A. (1969). Genetic aspects of learning and memory in mice. Sci. 163: 139–149.

    Article  CAS  Google Scholar 

  • Bovet, D., Bovet-Nitti, F., and Oliverio, A. (1966). Action of nicotine on spontaneous and acquired behavior in rats and mice. Ann. N. Y. Acad. Sci. 142: 261–267.

    Article  Google Scholar 

  • Brown, A.M. (1959). The investigation of specific responses in laboratory animals. Symposium. Laboratory Animals Centre, Royal Veterinary College, London pp. 9–16.

    Google Scholar 

  • Buxbaum, D.M., Yarbrough, G.G., and Carter, M.E. (1973). Biogenic amines and narcotic effects. I. Modification of morphine-induced analgesia and motor activity after alteration of cerebral amine levels. J. Pharmacol. Exp. Ther. 185: 317–327.

    PubMed  CAS  Google Scholar 

  • Castellano, C., and Oliverio, A. (1975). A genetic analysis of morphine induced running and analgesia in the mouse. Psychopharmacologia. 41: 197–200.

    Article  PubMed  CAS  Google Scholar 

  • Castellano, C., Espinet Llovera, B., and Oliverio, A. (1975). Morphine induced running and analgesia in two strains of mice following septal lessions or modification of brain amines. Arch. Pharmacol. 288: 355–370.

    Article  CAS  Google Scholar 

  • Castellano, C., Filibeck, U., and Oliverio, A. (1976). Effects of heroin, alone or in combination with other drugs, on the locomotor activity in two inbred strains of mice. Psychopharmacologia. 49: 29–31.

    CAS  Google Scholar 

  • Cheney, D.L., and Goldstein, A. (1971). The effect of p-Chlorophenylalanine on opiate-induced running, analgesia, tolerance, and physical dependence in mice. J. Pharmacol. Exp. Ther. 177: 309–315.

    PubMed  CAS  Google Scholar 

  • Cochin, J., and Kornetsky, C. (1964). Development and loss of tolerance to morphine in rats after single and multiple injection. J. Pharmacol. Exp. Ther. 145: 1–10.

    PubMed  CAS  Google Scholar 

  • Cox, B.M., Ginsburg, M. and Osman, O.H. (1968). Acute tolerance to narcotic analgesic drugs in rats. Brit. J. Pharmacol. 33: 245–256.

    PubMed  CAS  Google Scholar 

  • Criswell, E.H., and Levitt, R.A. (1975). The narcotic analgesics, in Psychopharmacology: A Biological Approach. R.A. Levitt, ed. John Wiley and Sons, New York. pp. 187–230.

    Google Scholar 

  • Domino, E.F., and Wilson, A. (1973). Effects of narcotic analgesic agonists and antagonists on rat brain acetylcholine. J. Pharmacol. Exp. Ther. 184: 18–32.

    PubMed  CAS  Google Scholar 

  • Ebel, A., Hermetet, J.C., and Mandel, P. (1973). Comparative study of acetylcholinesterase and choline-acetyltransferase enzyme activity in brain of DBA and C57 mice. Nat. New Biol. 242: 56–57.

    PubMed  CAS  Google Scholar 

  • Eddy, N.B., and Leimback, D. (1953). Synthetic analgesics. II. Dithienylbutenyl-and dithienyl-butylamines. J. Pharmacol. Exp. Ther. 107: 385–393.

    PubMed  CAS  Google Scholar 

  • Eleftheriou, B.E. (1971). Regional brain norepinephrine turnover rates in four strains of mice. Neuroendocrinol. 7: 329–336.

    Article  CAS  Google Scholar 

  • Elias, M.F. (1970). Differences in reversal learning between two inbred mouse strains. Psychonom. Sci. 20: 179–180.

    Google Scholar 

  • Eriksson, K. (1969). Factors affecting voluntary alcohol consumption in the albino rat. Ann. Zoo I. Fenn. 6: 227–236.

    Google Scholar 

  • Eriksson, K., and Kiianmaa, K. (1971). Genetic analysis of susceptibility to morphine addiction in inbred mice. Ann. Med. Exp. Fenn. 49: 73–78.

    PubMed  CAS  Google Scholar 

  • Evangelista, A.M., Gattoni, R.C., and Izquierdo, I. (1970). Effects of amphetamine, nicotine, and hexamethonium on performance of a conditioned response during acquisition and retention trails. Pharmacol. 3: 91–96.

    Article  CAS  Google Scholar 

  • Fuller, J.L. (1970). Strain differences in the effects of chlorpromazine and chlordiazepoxide upon active and passive avoidance in mice. Psychopharmacologian 16: 261–271.

    Article  CAS  Google Scholar 

  • Fuller, J.L. (1966). Variation of effects of chlorpromazine in three strains of mice. Psychopharmacologia. 8: 408–414.

    Article  PubMed  CAS  Google Scholar 

  • Fuller, J.L. (1964). Measurement of alcohol preference in genetic experiments. J. Comp. Physiol. Psychol. 57: 85–88.

    Article  PubMed  CAS  Google Scholar 

  • Gebhart, G.F., and Mitchell, C.L. (1973). Strain differences in the analgesic response to morphine as measured on the hot-plat. Arch. Int. Pharmacodyn. Thér. 201: 128–135.

    PubMed  CAS  Google Scholar 

  • Giarman, N.J., and Pepeu, G. (1962). Drug induced changes in brain acetylcholine. Brit. J. Pharmacol. 19: 226–234.

    PubMed  CAS  Google Scholar 

  • Gillette, J.R. (1965). Drug toxicity as a result of interference with physiological mechanisms. Ann. N. Y. Acad. Sci. 123: 42–53.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, A., and Sheehan, P. (1969). Tolerance to opioid narcotics. I. Tolerance to the “running fit” caused by Levorphanol in the mouse. J. Pharmacol. Exp. Ther. 169: 175–184.

    PubMed  CAS  Google Scholar 

  • Herz, A., Albus, K.., Metys, J., Schubert, P., and Teschemaker, H. (1970). On the central sites for the antinociceptive action of morphine and fentanyl. Neuropharmacol. 9: 539–551.

    Article  CAS  Google Scholar 

  • Herz, A., Blàsig, J., and Papeschi, R. (1974). Role of catecholaminergic mechanisms in the expression of the morphine abstinence syndrome in rats. Psychopharmacologia. 39: 121–143.

    Article  PubMed  CAS  Google Scholar 

  • Hollinger, M. (1969). Effects of reserpine, a-methyl-p-tyrosine, p-chlorophenylalanine, and pargyline on levorphanol induced running activity in mice. Arch. Int. Pharmacodyn Thér. 179: 419–424.

    PubMed  CAS  Google Scholar 

  • Huidobro, J.P., and Huidobro, F. (1973). Acute morphine tolerance in new born and young rats. Psychopharmacologia. 28: 27–34.

    Article  PubMed  CAS  Google Scholar 

  • Jhamandas, K.., and Dickinson, G. (1973). Modification of precipitated morphine and methadone abstinence by acetylcholine antagonists. Nat. New Biol. 245: 219–221.

    PubMed  CAS  Google Scholar 

  • Jhamandas, K., Pinsky, C., and Phillis, J.W. (1970). Effects of morphine and its antagonists on release of cerebral cortical acetylcholine. Nat. 238: 176–177.

    Article  Google Scholar 

  • Kalow, K. (1966). Genetic aspects of drug safety. App. Ther. 8: 44–46.

    CAS  Google Scholar 

  • Kempf, E., Greilsamer, J., Mack, G., and Mandel, P. (1974). Correlation of behavioral differences in three strains of mice with differences in brain amines. Nat. 247: 483–485.

    Article  CAS  Google Scholar 

  • Koppanyi, T., and Avery, M.A. (1966). Species differences and the clinical trial of new drugs: A review. Clin. Pharmacol. Ther. 7: 250–254.

    PubMed  CAS  Google Scholar 

  • Kuhar, M.J., Pert, B.C., and Snyder, S.H. (1973). Regional distribution of opiate receptor binding in monkey and human brain. Nat. 245: 447–450.

    Article  CAS  Google Scholar 

  • Laschka, E., Teschemaker, H., Mehrain, P., and Herz, A. (1976). Sites of action of morphine involved in the development of physical dependence in rats. Psychopharmacologia. 46: 141–147.

    Article  PubMed  CAS  Google Scholar 

  • Lindzey, G., Loehlin, J., Manosevitz, M., and Thiessen, D.D. (1971). Behavioral genetics. Ann. Rev. Psychol. 22: 39–94.

    Article  CAS  Google Scholar 

  • Lotti, J.V., Lomax, P., and George, R. (1966). Acute tolerance to morphine following systemic and intracerebral injection in the rat. Int. J. Neuropharmacol. 5: 32–42.

    Google Scholar 

  • Mack, C., Greilsamer, J., Kempf, E., and Mandel, P. (1973). Neurochemical correlates of genetically observed differences in performance levels in mice. Abstract I V. Int. Meeting of the International Society of Neurochemistry, Tokyo.

    Google Scholar 

  • Mandel, P., Ebel, A., Hermetet, J.C., Bovet, D., and Oliverio, A. (1973). Etudes des enzymes du système cholinergique chez les hybrides F,de souris se distinguant par leur aptitude au conditionnement. C.R. Acad. Sci. 276: 395 398.

    Google Scholar 

  • McClearn, G.E., and Rodgers, D.A. (1959). Differences in alcohol preference among inbred strains of mice. Quart. J. Stud. Ale. 20: 691 695.

    Google Scholar 

  • McClearn, G.E., Wilson, J.R., and Meredith, W. (1970). The use of isogenic and heterogenic mouse stocks in behavioral research, in Contributions to Behavior-Genetic Analysis: The Mouse as a Prototype. G. Lindzey and D.D. Thiessen, eds. Appleton-Century-Crofts, New York.

    Google Scholar 

  • Meier, H. (1963). Factors influencing drug metabolism, in Experimental Pharmacogenetics. Academic Press, New York. pp. 9–75.

    Google Scholar 

  • Oliverio, A. (1975). Genotype dependent electroencephalographic behavioral and analgesic correlates of morphine: An analysis in normal mice and in mice with septal lesions. Brain Res. 83: 135–141.

    Article  CAS  Google Scholar 

  • Oliverio, A. (1968). Neurohumoral systems and learning, in Psychopharmacology, a Review of Progress, 1957–1967. Public Health Service Publication D.H. Efron, ed. Washington, D.C. No. 1936, pp. 867–868.

    Google Scholar 

  • Oliverio, A., and Castellano, C. (1974a). Experience modifies morphine induced behavioral excitation of mice. Nat. 252: 229–230.

    Article  CAS  Google Scholar 

  • Oliverio, A., and Castellano, C. (1974b). Genotype-dependent sensitivity and tolerance to morphine and heroin: Dissociation between opiate-induced running and analgesia in the mouse. Psychopharmacologia. 39: 13–22.

    Article  PubMed  CAS  Google Scholar 

  • Oliverio, A., and Castellano, C. (1973). Pharmacogenetic aspects of learning and memory, in Proceedings Fifth International Congress of Pharmacology, San Francisco, 1972. G.H. Acheson, F.E. Bloom, J. Cochin, T.A. Loomis, R.A. Maxwell, and G.T. Okita, eds. Karger, Basel.

    Google Scholar 

  • Oliverio, A., Castellano, C, and Messeri, P. (1973). Genotype dependent effects of septal lesions on different types of learning in the mouse. J. Comp. Physiol. Psychol. 82: 240–246.

    Article  PubMed  CAS  Google Scholar 

  • Pepeu, G., Mulas, A., Ruffi, A., and Sotgiu, P. (1971). Brain acetylcholine levels in rats with septal lesions. Life Sci. 10: 181–184.

    Article  CAS  Google Scholar 

  • Pert, C.B., and Snyder, S.H. (1973). Opiate receptor: Demonstration in nervous tissue. Sci. 179: 1011–1014.

    Article  CAS  Google Scholar 

  • Quinn, G., Axelrod, J., and Brodie, B.B. (1954). Species and sex differences in metabolism and duration of hexobarbital. Fed. Proc. 13: 395.

    Google Scholar 

  • Reggiani, A., Battaini, F., Kobayashi, H., Spans, P.F., and Trabucchi, M. (1980). Genotype- dependent sensitivity to morphine: role of different receptor populations. Brain Res. 189: 289–294.

    Article  PubMed  CAS  Google Scholar 

  • Renzi, P., and Sansone, M. (1971). Discriminated lever-press avoidance in mice. Comm. Behav. Biol. 6: 315–321.

    Google Scholar 

  • Rethy, C.R., Smith, C.B., and Villarreal, J.E. (1971). Effects of narcotic analgesics upon the locomotor activity and brain catecholamine content of the mouse. J. Pharmacol. Exp. Ther. 176: 472–479.

    PubMed  CAS  Google Scholar 

  • Samanin, R., and Valzelli, L. (1972). Serotoninergic neurotransmission and morphine activity. Arch. Int. Pharmacodyn. Ther. 196: 138–141.

    PubMed  Google Scholar 

  • Sansone, M., and Messeri, P. (1973). Strain differences in the effects of chlordiazepoxide and chlorpromazine on avoidance behavior of mice. Pharmacol. Res. Comm. 6: 179–185.

    Article  Google Scholar 

  • Schlesinger, K., and Griek, B.J. (1970). The genetics and biochemistry of audiogenic seizures, in Contributions to Behavior genetic Analysis: The Mouse as a Prototype. G. Lindzey and D.D. Thiessen, eds. Appleton-Century-Crofts, New York. p. 219.

    Google Scholar 

  • Seevers, M.H., and Deneau, G.A. (1963). Physiological aspects of tolerance and physical dependence, in Physiological Pharmacology. W.S. Root and F.G. Hofmann, eds. Academic Press, New York. Vol. 1, pp. 565–640.

    Google Scholar 

  • Sharkawi, M. (1970). Effects of morphine and pentobarbitone on acetylcholine synthesis by rat cerebral cortex. Brit. J. Pharmacol. 40: 86–91.

    CAS  Google Scholar 

  • Shuster, L., Hannam, R.V., and Boyle, W.E., Jr. (1963). A simple method for producing tolerance to dihydromorphinone in mice. J. Pharmacol. Exp. Ther. 140: 149–154.

    PubMed  CAS  Google Scholar 

  • Sprott, R.L. (1971). Inheritance of avoidance learning. Jackson Lab. Ann. Rep. 42: 78–85.

    Google Scholar 

  • Srebro, B., Oderfeld-Novak, B., Klodos, I., Dabrowka, J., and Narkiewicz, O. (1973). Changes in acetylcholinesterase activity in hippocampus produced by septal lesions in the rat. Life Sci. 12: 261–270.

    Article  CAS  Google Scholar 

  • Staats, J.L. (1972). Standard nomenclature for inbred strains of mice: Fifth listing. Cancer Res. 32: 1609–1630.

    PubMed  CAS  Google Scholar 

  • Trabucchi, M., Spano, P.F., Racagni, G., and Oliverio, A (1976). Genotype-dependent sensitivity to morphine: Dopamine involvement in morphine-induced running in the mouse. Brain Res. 14: 536–540.

    Article  Google Scholar 

  • Valatx, J.L., Bugat, R., and Jouvet, M. (1972). Genetic studies of sleep in mice. Nat. 238: 226–227.

    Article  CAS  Google Scholar 

  • van Abeelen, J.H.F. (1966). Effects of genotype on mouse behaviour. Anim. Behav. 14: 218–220.

    Article  PubMed  Google Scholar 

  • Villarreal, J.E., Guzman, M., and Smith, C.B. (1973). A comparison of the effects of d-amphetamine and morphine upon the locomotor activity of mice treated with drugs which alter brain catecholamine content. J. Pharmacol. Exp. Ther. 187: 1–7.

    PubMed  CAS  Google Scholar 

  • Wahlsten, D. (1972). Genetic experiments with animal learning: A critical review. Behav. Biol. 7: 143–182.

    Article  PubMed  CAS  Google Scholar 

  • Way, E.L., Ho, I.K., and Loh, H.H. (1973). Relations of brain serotonin to the inhibition and enhancement of morphine tolerance and physical dependence, in New Concepts in Neurotransmitter Regulation. A.J. Mandell, ed. Plenum Press, New York.

    Google Scholar 

  • Wey, E., Loh, H.H., and Way, E.L. (1973). Brain sites of precipitated abstinence in morphine- dependent rats. J. Pharmacol. Exp. Ther. 185: 108–115.

    Google Scholar 

  • Williams, R.T. (1962). Altered Drug Metabolism. Ciba Foundation Symposium on Enzymes and Drug Action. Little, Brown & Co., Boston, pp. 239–244.

    Google Scholar 

  • Wimer, C.C., Wimer, R.E., and Roderick. T.H. (1971). Some behavioral differences associated with relative size of hippocampus in the mouse. J. Comp. Physiol. Psychol. 76: 57–65.

    Article  PubMed  CAS  Google Scholar 

  • Yarbrough, G.G., Buxbaum, D.M., and Sanders-Bush, E. (1973). Biogenic amines and narcotic effects. II. Serotonin turnover in the rat after acute and chronic morphine administration. J. Pharmacol. Exp. Ther. 185: 328–335.

    PubMed  CAS  Google Scholar 

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Oliverio, A., Castellano, C. (1981). Behavioral Effects of Opiates: A Pharmacogenetic Analysis. In: Essman, W.B., Valzelli, L. (eds) Current Developments in Psychopharmacology. Current Developments in Psychopharmacology, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-8123-5_2

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  • DOI: https://doi.org/10.1007/978-94-011-8123-5_2

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