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Mode of Cyclic AMP Action in Growth Control

  • Yoon Sang Cho-Chung

Abstract

It is now well recognized that cyclic adenosine 3’,5’-monophosphate (cyclic AMP), a nucleotide present in a wide variety of organisms, is a major regulator of numerous cellular activities (71), (93), (113). The intracellular accumulation of cyclic AMP, either endogenously generated or exogenously supplied, inhibits the growth of normal and transformed cells in vivo and in vitro [see review (16)]. There is also evidence that an inverse correlation exists between the level of cellular cyclic AMP and the rate of cell growth. Unrestrained growth, a characteristic of neoplastic cells, however, is not always associated with diminished levels of cyclic AMP. Several studies have shown wide ranges of cyclic AMP. levels in proliferating tissues of animals and humans (16). Moreover, an increase in cellular cyclic AMP has been produced in tumors following treatment with N6,O2-dibutyryl cyclic AMP (dibutyryl cyclic AMP) although tumor regression occurs only in tumors that are responsive to dibutyryl cyclic AMP (14). In our investigations on the mechanism of dibutyryl cyclic AMP-responsiveness, we utilized rat mammary tumor models that were either “responsive” or “unresponsive” to dibutyryl cyclic AMP treatment.

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  • Yoon Sang Cho-Chung

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