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The Role of Lipids in Virus—Cell Interactions

  • Chapter
Virus Receptors

Part of the book series: Receptors and Recognition ((RERE,volume 7))

Abstract

Enveloped viruses are coated with a lipid matrix of varying complexity. This is present in a bilayer and is an essential constituent since treatment with lipid solvents, detergents or lipase inactivates infectivity and hemagglutination (Kuwert et al., 1968). Lipid composition has been closely studied in only a few viruses, examples being VSV (McSharry and Wagner, 1977), rabies virus (Blough et al., 1977; Diringer et al., 1973; Schlesinger et al., 1973) and Uukuniemi virus (an Arbovirus, Renkonen et al., 1973). An early review of lipid composition in viruses was provided by Blough and Tiffany (1973). The viral lipid composition may reflect that of host membranes, since it is often obtained during a budding process and the lipid composition of some viruses varies widely after replication in different cell systems (Klenk and Choppin, 1969, 1970; McSharry and Wagner, 1971 ; Semmel et al., 1975). The production of infectious paramyxoviruses is strongly dependent on the lipid composition of the host (Klent and Choppin, 1970b; St. Gerne et al., 1977).

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Abbreviations

PL:

phospholipid

PC:

phosphatidylcholine

PE:

phosphatidylthanolamine

PS:

phosphatidylserine

SPM:

sphingomyelin

VSP:

Vesicular stomatis virus

NDV:

Newcastle disease virus

NMR:

nuclear magnetic resonance

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Authors
  1. John Bramhall
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  2. Bernadine Wisnieski
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Editors and Affiliations

  1. Du Pont Central Research and Development Department, Delaware, USA

    K. Lonberg-Holm

  2. The Wallenberg Laboratory, University of Uppsala, Sweden

    L. Philipson

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Bramhall, J., Wisnieski, B. (1981). The Role of Lipids in Virus—Cell Interactions. In: Lonberg-Holm, K., Philipson, L. (eds) Virus Receptors. Receptors and Recognition, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-8022-1_7

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  • DOI: https://doi.org/10.1007/978-94-011-8022-1_7

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