Abstract
Special precautions are needed in the chemotherapy of the premature and newborn infant whose renal and hepatic function is not fully developed. This subject is dealt with separately (see section 21). Because of the increased likelihood of infection occurring in patients with renal and hepatic insufficiency, and because of the serious nature of infection in these compromised patients, an understanding of the use of antibacterial drugs in these situations is very important if toxic effects are to be avoided.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bhagwat, A.G. and Warren, R.E.: Hepatic reaction to nitrofurantoin. Lancet 2: 1369 (1969).
Bulger, R.J.; Lindholm, D.D.; Murray, J.S. and Kirby, W.M.M.: Effect of uremia on methicillin and oxacillin blood levels. Journal of the American Medical Association 187: 319–322 (1964).
Conn, H.O.; Binder, H.J. and Orr, H.D.: Ethionamide-induced hepatitis: a review with a report on an additional case. American Review of Respiratory Diseases 90: 542–552 (1964).
Curtis, J.R. and Eastwood, J.B.: Colistin sulphomethate sodium administration in the presence of severe renal failure and during haemodialysis and peritoneal dialysis. British Medical Journal 1: 484–485 (1968).
Dismukes, W.E.: Oxacillin-induced hepatic dysfunction. Journal of the American Medical Association 226:861–863(1973).
Dujovne, C.A.; Chan, C.H. and Zimmerman, H.J.: Sulphonamide hepatic injury. New England Journal of Medicine 277: 785–788 (1967).
Eastwood, J.B. and Curtis, J.R.: Carbenicillin administration in patients with severe renal failure. British Medical Journal 1: 486–487 (1968).
Fischer, E.: Renal excretion of sulphadimidine in normal and uraemic subjects. Lancet 2: 210–212 (1972).
Garrod, L.P.; Lambert, H.P. and O’Grady, F.: in Dosage in Antibiotic and Chemotherapy 4th Ed, Chapter 17, p.291–306 (Churchill Livingstone, Edinburgh and London 1973).
Gray, J.A.; Geddes, A.M.; Wallace, E.T. and Murdoch, J. McC.: Symposium on Pyelonephritis, Edinburgh 1966. Supplement to British Journal of Urology, p.33–37 (E and S Livingstone, Edinburgh 1967).
Hoeprich, P.R.: The polymyxins. Medical Clinics of North America 54: 1257–1265 (1970).
Knirsch, A.K. and Gralla, E.J.: Serum transaminase levels after parenteral ampicillin and carbenicillin administration. New England Journal of Medicine 282: 1081–1082 (1970).
Kovnat, P.; Labovitz, E. and Levison, S.P.: Antibiotics and the kidney. Medical Clinics of North America 57: 1045–1063 (1973).
Kucers, A. and Bennett, N. McK.: in Lincomycin and Clindamycin in the Use of Antibiotics 2nd Ed p.284–302 (William Heinemann Medical Books, London 1975).
Kunin, C.M.: A guide to the use of antibiotics in patients with renal disease. Annals of Internal Medicine 67: 151–158(1967).
Kunin C.M.; Glazko, A.J. and Finland, M.: Persistence of antibiotics in blood of patients with acute renal failure. II Chloramphenicol and its metabolic products in the blood of patients with severe renal disease or hepatic cirrhosis. Journal of Clinical Investigations 38: 1498–1508 (1959).
Leading Article: Tetracycline and blood urea. British Medical Journal 3: 370 (1972).
Lepper, M.H.; Wolfe, C.K.; Zimmerman, H.J.; Caldwell, E.R., Spies, H.W. and Dowling, H.F.: Effect of large doses of aureomycin on human liver. Archives of Internal Medicine 88: 271–283 (1951).
Lew, H.T. and French, S.W.: Tetracycline nephrotoxicity and nonoliguric acute renal failure. Archives of Internal Medicine 118: 123–128 (1966).
McGeachie, J.; Girdwood, R.W.A., Burton, J.A. and Kennedy, A.C.: Impaired renal function and serum levels of rifamide. Scottish Medical Journal 15: 257–260 (1970).
Moulding, T.S. and Goldstein, S.: Hepatotoxicity due to ethionamide. American Review of Respiratory Diseases 86: 252–255(1962).
Ogg, C.S.; Toseland, P.A. and Cameron, J.S.: Pulmonary tuberculosis in patients on intermittent haemodialysis. British Medical Journal 2: 283–284 (1968).
O’Grady, F.: Antibiotics in renal failure. British Medical Bulletin 27: 142–147 (1971).
Phillips, S. and Tashman, H.: Ethionamide jaundice. American Review of Respiratory Diseases 87: 896–898(1963).
Plaut, M.E.; O’Connell, C.J.: Pabico R.C and Davidson, D.: Penicillin handling in normal and azotemic patients. Journal of Laboratory and Clinical Medicine 74: 12–18 (1969).
Schultz, J.C.; Adamson, J.S.; Workman, W.W. and Norman, T.W.: Fatal liver disease after intravenous administration of tetracycline in high dosage. New England Journal of Medicine 269: 999–1004 (1963).
Strauss, W. and Jawetz, E.: Nitrofurantoin in patients with hepatic dysfunction. Clinical Pharmacology and Therapeutics 4: 297–303 (1963).
Welling, P.G.; Craig, W.A.; Amidon, G.L. and Kunin, C.M.: Pharmacokinetics of trimethoprim and sulfamethoxazole in normal subjects and in patients with renal failure. Journal of Infectious Diseases 128 (Suppl.): 556–566 (1973).
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1978 ADIS Press
About this chapter
Cite this chapter
Ball, A.P., Gray, J.A., Murdoch, J.M. (1978). Antibacterial Therapy in Renal and Hepatic Disease. In: Antibacterial Drugs Today. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-8004-7_20
Download citation
DOI: https://doi.org/10.1007/978-94-011-8004-7_20
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-85200-505-7
Online ISBN: 978-94-011-8004-7
eBook Packages: Springer Book Archive