Abstract
Metronidazole has been used effectively for many years in the management of protozoal infestation, both with Trichomonas and Entamoeba histolytica. However, although it was found to be effective in Vincent’s angina some 15 years ago (Shinn, 1962), it was not until the recent upsurge of interest in anaerobic infection had occurred, that the agent became established as a powerful anti-anaerobic drug. Its activity, particularly against the obligate anaerobes, recently reviewed by Ingham et al. (1975a), places it amongst the drugs of first choice in these infections.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Busch, D.F.; Sutter, V.L. and Finegold, S.M.: Activity of combinations of antibacterial agents against Bacteroides fragilis. Journal of Infectious Diseases 133: 321–328 (1976).
Davies, A.H.: Metronidazole in human infections with syphilis. British Journal of Venereal Diseases 43: 197–200 (1967).
Eykyn, S.J. and Phillips, I.: Metronidazole and anaerobic sepsis. British Medical Journal 2: 1418–1421 (1976).
Finegold, S.M.; Bartlett, A.W., Chow, D.J. et al.: Management of anaerobic infections. Annals of Internal Medicine 83: 375–389 (1975).
Gray, M.S.; Kane, P.O. and Squires, S.: Further observations on metronidazole (Flagyl). British Journal of Venereal Diseases 37: 278–279 (1961).
Hamilton-Miller, J.M.T.: Antimicrobial agents acting against anaerobes. Journal of Antimicrobial Chemotherapy 1: 273–289 (1975).
Ingham, H.R.; Selkon, J.B. and Hale, J.H.: The antibacterial activity of metronidazole. Journal of Antimicrobial Chemotherapy 1: 355–361 (1975a).
Ingham, H.R.; Selkon, J.B. and Hale, J.H.: Treatment with metronidazole of three patients with serious infections due to Bacteroides fragilis. Journal of Antimicrobial Chemotherapy 1: 235–242 (1975b).
Nastro, L.J. and Finegold, S.M.: Bactericidal activity of five antimicrobial agents against Bacteroides fragilis. Journal of Infectious Diseases 126: 104–107 (1972).
Salem, A.R.; Jackson, D.D. and McFadzean, J.A.: An investigation of interactions between metronidazole (Flagyl) and other antibacterial agents. Journal of Antimicrobial Chemotherapy 1: 382–391 (1975).
Selkon, J.B.; Hale, J.H. and Ingham, H.R.: Metronidazole in the treatment of anaerobic infection in man. Proceedings of the 9th International Congress of Chemotherapy (London 1975).
Shinn, D.L.S.: Metronidazole in acute ulcerative gingivitis. Lancet 1: 1191 (1962).
Study Group: An evaluation of metronidazole in the prophylaxis and treatment of anaerobic infections in surgical patients. Journal of Antimicrobial Chemotherapy 1: 393–401 (1975).
Tally, F.P.; Sutter, V.L. and Finegold, S.M.: Treatment of anaerobic infections with metronidazole. Antimicrobial Agents and Chemotherapy 7: 672–675 (1975).
Welling, P.G. and Monro, A.M.: The pharmacokinetics of metronidazole and tinidazole in man. Arzneimittel-Forschung 22: 2128–2132 (1972).
Willis, A.T. et al.: Metronidazole in prevention and treatment of Bacteroides infections after appendicec-tomy. British Medical Journal 1: 318–321 (1976).
Willis, A.T. et al.: Metronidazole in prevention and treatment of Bacteroides infections in elective colonic surgery. British Medical Journal 1: 607–610 (1977).
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1978 ADIS Press
About this chapter
Cite this chapter
Ball, A.P., Gray, J.A., Murdoch, J.M. (1978). Metronidazole. In: Antibacterial Drugs Today. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-8004-7_16
Download citation
DOI: https://doi.org/10.1007/978-94-011-8004-7_16
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-85200-505-7
Online ISBN: 978-94-011-8004-7
eBook Packages: Springer Book Archive