Abstract
One of the prime objectives of medical research over the past 50 years has been the discovery and development of an analgesic agent having the efficacy of morphine without the liability to abuse which characterizes the narcotics. All the opioid drugs introduced during this period have claimed superiority over morphine in terms of abuse potential. Most of them have ultimately failed to live up to the full extent of the claims made; nevertheless several widely used drugs have been less abused than morphine.
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Lewis, J.W. (1982). The antagonist analgesic concept. In: Glatt, M.M., Marks, J. (eds) The Dependence Phenomenon. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7457-2_4
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