Abstract
It is well known that Lithium Carbonate, which is utilized in psychiatric patients, induces a reversible neutrophilic leucocytosis which persists during the administration and resolves within a week of discontinuance of the drug (7–8). During cancer chemotherapy, neutropenia is one of the most frequent and harmful side-effects because of the possibili ty of infectious events and the necessity of reducing drug dosage and/or delaying the performance of therapeutic cour ses, compromising treatment efficacy (1).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bonadonna, G., Valagussa, P. (1981). Dose-response effect of adjuvant chemotherapy in breast cancer. New Engl. J. Med., 304, 10–15
Casirola, G., Invernizzi, R., Ippoliti, G. et al. (1980) Effetti del Litio carbonato sulle neutropenie primitive e secondarie. Haematologica, 65, 746–754
Chan, H, S. L., Saunders, E.F., Freedman M.H. (1980). Modulation of human hematopoiesis by prostagladins and Lithium. J. Lab. Clin. Med., 95, 125–132
De Vita, V. Jr, Hellman, S., Rosenberg, S. (1982). Cancer: principles and practice of Oncology pp. 140–141 (J.B. Lippincott Co. Philadelphia, Toronto).
Harker, G.W., Rothstein, G., Clarkson, D. et al. (1977). Enhancement of colony-stimulating activity production by Lithium. Blood, 49, 263–267
Lyman, G.H., Williams, C.C., Preston, D. (1980). The use of Lithium carbonate to reduce infection and leukopenia during systemic chemotherapy. New Engl. J. Med., 302, 257–260
Radomsky, J.L., Fuyat, H.N., Nelson, A.A. et al (1950). The toxic effects, excretion and distribution of Lithium chloride. J. Pharmacol. Exp. Ther., 100, 429–444
Risetto, G., Gassano, G. (1952). Variazione del sangue periferico nella intossicazione sperimentale da sali di Litio. Riv. Patol. Clin. Sper., 7 202–205
Schabel, F.M. Jr, Simpson-Herren, L. (1978). Some variables in experimental tumor systems which complicate interpretation of data from in vivo kinetic and pharmacologic studies with anticancer drugs. Antiblastic Chemotherapy, 23, 113–127
Spitzer, G., Verma, D.S., Barlogie, B. et al. (1979). Possible mechanisms of action of Lithium on an augmentation of in vitro spontaneus myeloid colony formation. Cancer Res., 39, 3215–3219
Stein, R.S. (1977). Lithium carbonate in chemotherapy-induced neutropenia. New Engl. J. Med., 297, 1180
Trivisonne, R., Piga, A., Cellerino, R. (1981). Effetto del Litio sul midollo emopoietico murino coltivato in vitro. Tumori, 67, suppl.2, 171
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 MTP Press Limited
About this chapter
Cite this chapter
Menichetti, E.T., Silva, R.R., Cellerino, R. (1984). Cancer chemotherapy induced neutropenia: effects of lithium carbonate. In: Corsini, G.U. (eds) Current Trends in Lithium and Rubidium Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7318-6_23
Download citation
DOI: https://doi.org/10.1007/978-94-011-7318-6_23
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-7320-9
Online ISBN: 978-94-011-7318-6
eBook Packages: Springer Book Archive