Abstract
One of the most intriguing aspects of the treatment of patients with affective disorders is the drug-induced sudden reversal of mood, from depression to mania or viceversa (1). Bunney reviewed 80 studies involving 3923 patients treated with tricyclic antidepressants or monoamineoxidase inhibitors and found that 9.6 per cent of these patients had switched from depression to mania or hypomania during the treatment (1). Recently it was reported that the frequency of drug-induced switches is much greater in bipolar than in unipolar patients (2).
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References
Bunney, W.E. Jr. (1978). Psychopharmacology of the switch process in affective illness. In: Lipton, M. Di Mascio, A., Killam, K. F. (eds). Psychopharmacology: A Generation of Progress. pp. 1249–1259.(New York: RavenPress)
Lewis, J.L. and Winokur, G. (1982). The induction of mania. Arch.Gen.Psichiatry 39, 303–6
Quitkin, F. M., Kane, J., Rifkin, A., Ramos-Lorenzi, J. R., Nayak, D.V. (1981). Prophylactic lithium carbonate with and without imipramine for bipolar 1 patients. Arch.Gen.Psychiatry 38, 902–7
Goodwin, F.K., Cowdry, R.W., Webster, M.H. (1978). Predictors of drug-response in the affective disorders: towards an integrated approach. In: Lipton, M. et al (eds). Psychopharmacology: A generation of Progress. pp. 1277–1288. (New York: Raven Press)
Gerbino, L., Oleshansky, M., Gershon, M. (1978). Clinical use and mode of action of lithium. In: Lipton, M. et al. (eds). Psychopharmacology: A Generation of Progress. pp. 1261–1275.(New York: Raven Press)
Cazzullo, C.L. and Sacchetti, E. Critical issues in the evaluation of long term lithium treatment. This book.
Wehr, T.A. and Goodwin, F.K. (1979). Rapid cycling in manic-depressive illness induced by tricyclic antidepressants. Arch. Gen. Psychiatry 36, 555–9
Waters, G.H. and LaPierre, Y.D. (1982). Therapeutic use of the trieyclic-induced switch in bipolar manicdepression. Am.J.Psychiatry 139, 225–6
Sacchetti, E., Faravelli, C., Conte, G., Pennati, A., Vita, A., Cazzullo, C.L. (1983) Monoaminergic profiles in major affective disorders and clinical response to long term lithium treatment. Submitted for publication.
Winokur, G. (1978). Mania and depression: family studies and genetics in relation to treatment. In:Lipton, M et al (eds). Psychopharmacology: A Generation of Progress. pp. 1213–1221. (New York: Raven Press)
van Scheyen, J.D. and van Kammen, D.P. (1979). Clomipramine-induced mania in unipolar depression. Arch. Gen. Psychiatry 36, 560–5
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Conte, G., Vita, A., Alciati, A., Pennati, A., Sacchetti, E. (1984). Antidepressant-induced switch and outcome to lithium prophylaxis in bipolar patients. In: Corsini, G.U. (eds) Current Trends in Lithium and Rubidium Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7318-6_16
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DOI: https://doi.org/10.1007/978-94-011-7318-6_16
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-7320-9
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