Abstract
Prazosin [1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-piperazine] is the first member of a new class of antihypertensive agents (fig. 1).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Amery, A.; Verhiest, W.; Crooneberghs, J. and Fagard, R.: Double-blind crossover study with a new vasodilator — prazosin — in the treatment of mild hypertension. Hypovase Symposium, Geneva (March 1974).
Bailey, R.R.: The kidney and antihypertensive therapy. Drugs 11 (Suppl. 1): 70 (1976).
Bailey, R.R.: Prazosin in the treatment of patients with hypertension and renal function impairment. Special Supplement to the Medical Journal of Australia 2: 42 (1977).
Bailey, R.R.; Lynn, K.L.; Neale, T.L. and Little, P.J.: Prazosin in the treatment of patients with hypertension and renal function impairment. New Zealand Medical Journal 84: 467 (1967).
Bendall, M.J.; Baloch, K.H.; Wilson, P.R.: Side-effects due to treatment of hypertension with prazosin. British Medical Journal 2: 727 (1975).
Bianchetti, G.; Graziani, G.; Brancaccio, D.; Morganti, A.; Leonetti, G.; Manfrin, M.; Sega, R.; Gomeni, R.; Ponticelli, G. and Morselli, P.L.: Pharmacokinetics and effects of propranolol in terminal uraemic patients and in patients undergoing regular dialysis treatment. Clinical Pharmacokinetics 1: 373 (1976).
Bloom, D.S.; Rosendorff, C. and Kramer, R.: Clinical evaluation of prazosin as the sole agent for the treatment of hypertension: A double-blind crossover study with methyldopa. Current Therapeutic Research 18 (1): 144 (1975).
Bolu, P. and Simpson, F.O.: A preliminary clinical trial of prazosin: a new oral antihypertensive agent. New Zealand Medical Journal 79: 969 (1974).
Bolli, P. and Simpson, F.O.: Experience with prazosin in the treatment of hypertension. Postgraduate Medicine (Suppl. Nov): 69 (1975).
BoUi, P.; Wood, A.J.; Phelan, E.L.; Lee, D.R. and Simpson, P.O.: Prazosin: preliminary clinical and pharmacological observations. Clinical Science and Molecular Medicine 48: 177S (1975).
Bolli, P.; Wood, A.J. and Simpson, P.O.: Effects of prazosin in patients with hypertension. Clinical Pharmacology and Therapeutics 20: 138 (1976).
Bolzano, K.: Prazosin, a new quinazoline derivative in the treatment of essential hypertension. In Cotton (Ed) Prazosin — Evalution of a new antihypertensive agent (Excerpta Medica, Amsterdam 1974).
Bradley, W.P.: A long-term clinical trial of prazosin. Postgraduate Medicine (Suppl. Nov): 95 (1975).
Bradley, W.F.: Hoffman, P.O.; Hutchison, J.C.; Kalams, Z. and Waldron, S.L.: Comparison of prazosin and methyldopa in mild to moderate hypertension, a multicenter cooperative study. Current Therapeutic Research 21: 28 (1977).
Cairns, S.A. and Jordan, S.C.: Prazosin treatment complicated by acute febrile polyarthritis. British Medical Journal 2: 1424 (1976).
Cambridge, D.; Davey, M.J. and Massingham, R.: Prazosin, a selective antagonist of post-synaptic a- adrenoceptors. British Journal of Pharmacology 59: 514P (1977a).
Cambridge, D.; Davey, M.J. and Massingham, R.: The pharmacology of antihypertensive drugs with special reference to vasodilators, a-adrenergic blocking agents and prazosin. Medical Journal of Australia 2 (Suppl.): 2 (1977b).
Cambridge, D.; Davey, M.J. and Massingham, R.: Purther evidence for a selective postsynaptic a- adrenoceptor blockade with prazosin in vascular smooth muscle. Nauyn-Schmeideberg’s Archives of Pharmacology 302 (Suppl.) Abstract 206 (1978).
Cavero, I.: Cardiovascular effects of prazosin in dogs. Clinical Science and Molecular Medicine 57: 609S (1976).
Cavero, I.; Penard, S.; Gomeni, R.; Lefevre, P. and Roach, A.G.: Studies on the mechanism of the vasodilator effects of prazosin in dogs and rabbits. European Journal of pharmacology 49: 259 (1978).
Cavero, I. and Lefevre, P.: Cardiovascular effects of prazosin in spontaneously hypertensive rats (SHR). Clinical and Experimental Pharmacology and Physiology 4 (Suppl. 3): 61 (1977).
Cavero, I.; Lefevre, P. and Roach, A.: Purther studies on cardiovascular effects of prazosin. Federation Proceedings 36: 955 (1977a).
Cavero, I.; Lefevre, P. and Roach, A.G.: Differential effects of prazosin on the pre- and postsynaptic a- adrenoceptors in the rat and dog. British Journal of Pharmacology 61: 469p (1977b).
Cohen, B.M.: Prazosin hydrochloride (CP-12, 229–1), an oral antihypertensive agent prehminary clinical observations in ambulatory patients. Journal of Clinical Pharmacology 10: 408 (1970).
Collier, J.G.; Lorge, R.E. and Robinson, B.P.: Comparison of effects tohnesoxide (RX 71107), diazoxide, hydrallazine, prazosin, glyceryl trinitrate and sodium nitroprusside on forearm arteries and dorsal hand veins of man. British Journal of Clinical Pharmacology 5: 35 (1978).
Collins, I.S. and Pek, P.: Pharmacokinetics of prazosin, a new antihypertensive compound. Clinical and Experimental Pharmacology and Physiology 2: 445 (1975).
Constantine, J.W.: Analysis of the hypertensive action of prazosin; in Cotton, (Ed) Prazosin — Evaluation of a new antihypertensive agent (Excerpta Medica, Amsterdam 1974).
Constantine, J.W.; McShane, W.K.; Scriabine, A. and Hess, H.J.: Analysis of the hypotensive action of prazosin. In Onesti, Kim and Moyer (Eds) Hypertension: Mechanisms and Management, p.449 (Grune and Stratton, New York 1973).
Curtis, J.R.: Prazosin in patients with chronic renal failure. British Medical Journal 3: 742 (1974).
Curtis, J.R. and Bateman, F.J.A.: Use of prazosin in management of hypertension in patients with chronic renal failure and renal transplant recipients. British Medical Journal 4: 432 (1975).
de la Paz, A.G.; Aquino, A. and Sawit, S.: Prazosin hydrochloride in the treatment of hypertension. Philippine Journal of Internal Medicine 3: 125 (1975).
de la Paz, A.G.; Reyes, A.L.; de Guia, R.; Saldivar, C.; Aquino, A.; Saniel, E.G.; Durante, M. and Un- son, L.: A new quinazoline derivative in the treatment of hypertension. A co-operative study in four medical centres in the Philippines. Philippine Journal of Cardiology 4: 47 (1976).
England, J.D.; Trembath, P.W. and Shaw, J.: Plasma cyclic 3’ 5’ |denosine monophosphate (CAMP) levels in hypertension: Effects of treatment Abstract of paper presented at Annual Meeting of Australasian Society of Clinical and Experimental Pharmacologists, Adelaide, November 1976.
Falase, A.O.; Salako, L.A.; Aminu, J.M.: Lack of effect of low doses of prazosin in hypertensive Nigerians. Current Therapeutic Research 19: 603 (1976).
Feng, P.H.; Chan, H.C.; Tan, N.J. and Lee, Y.K.: Prazosin hydrochloride in the treatment of hypertension. Annals of the Academy of Medicine 5: 157 (1976).
Feng, P.H.; Ng, K.K.F.; Chan, H.C.; Tan, N.J. and Lee, Y.K.: Renin characterisation of hypertensive patients treated with vasodilation, beta-blockade and volume depletion. Annals of the Academy of Medicine, Singapore 4: 274 (1975).
Femandes, M.; Smith, LS.; Weder, A. et al.: Prazosin in the treatment of hypertension. Clinical Science and Molecular Medicine 48: 18IS (1975).
Graham, R.M.; Muir, M.R. and Hayes, J.M.: Effects of prazosin on blood pressure and plasma renin activity in the anaesthetised dog. Australian and New Zealand Journal of Medicine 4: 424 (1974).
Graham, R.M.; Gates, H.F.; Stoker, LM. and Stokes, G.S.: Mechanism of action of prazosin, an antihypertensive agent. Abstract of paper presented at Annual Meeting of Australasian Physiological and Pharmacological Society, Melbourne (August 1976a).
Graham, R.M.; Thornell, LR.; Gain, J.M.; Bagnoli, C.; Gates, H.F. and Stokes, G.S.: Prazosin: the first- dose phenomenon. British Medical Journal 2: 1293 (1976b).
Graham, R.M.; Muir, M.R. and Hayes, J.M.: Differing effects of the vasodilator drugs, prazosin and diazoxide on plasma renin activity in the dog. Clinical and Experimental Pharmacology and Physiology 3: 193 (1976c).
Gabriel, R.; Meek, D. and Mamtora, H.: Adverse reactions to prazosin. Brit. med. J. 4: 41 (1975a).
Gabriel, R.; Meek, D. and Mamtora, H.: Adverse reactions to prazosin. Brit. med. J. 3: 41 (1975b).
Guevara-Viales, L.: Prazosin: New antihypertensive drug. Comparative study with a-methyldopa (translation). Revista Medica de Costa Rica 43: 11 (1976).
Hayes, J.M.: Prazosin in severe hypertension. Effect on blood pressure, plasma renin activity and in hypertensive emergencies. Medical Journal of Australia 2 (Suppl.): 30 (1977).
Hayes, J.M.; Graham, R.M.; O’Connell, B.P.; Speers, E. and Humphrey, T.J.: Effect of prazosin on plasma renin activity. Australian and New Zealand Journal of Medicine 6: 90 (1976b).
Hayes, J.M.; Graham, R.M.; O’Connell, B.P.; Speers, E. and Humphrey, T.J.: Experience with prazosin in the treatment of patients with severe hypertension. Medical Journal of Australia 1: 562 (1976a).
Hess, H.J.: Biochemistry and structure-activity studies with prazosin; in Cotton (Ed) Prazosin — Evaluation of a new antihypertensive agent. (Excerpta Medica, Amsterdam 1974).
Hobbs, D.C. and Twomey, T.M.: Pharmacokinetics of prazosin in man. Unpublished data (1977).
Hua, S.P.; MacDonald, Ileene M.; Myers, J.B. and Kincaid-Smith, P.: Studies with prazosin a new effective hypertensive agent. Medical Journal of Australia 1: 559 (1976).
Hua, A.S.P.; MacDonald, Ileene, M.: Myers, J.B.; Fang, P. and Kincaid-Smith, Priscilla: Studies with prazosin. A new effective hypotensive agent II Two double-blind cross-over studies comparing the effects of prazosin and hydrallazine. Medical Journal of Australia 2: 5 (1977a)
Hua, A.S.P. and Moulds, R.F.W.: The effect of prazosin on pre- and post-synaptic a-adrenoceptors in the pithed rat. Australasiän Society of Clinical and Experimental Pharmacologists Proceedings, Sydney (Nov. 1977b).
Hua, A.S.P.; Myers, J.B. and Kincaid-Smith, P.: Studies with prazosin — a new effective hypotensive agent. Ill An acute double-blind cross-over study comparing the effects of single doses of prazosin and hydrallazine in combination with propranolol and a diuretic. Medical Journal of Australia 1: 45 (1978).
Ibsen, H.; Rasmussen, K. and Herenlund, H.: Hendringer i plasma-volume, extracellulaervolumen og den glomerulaere filtrationshastighed under kombinationsbehandling med propranolol og prazosin has patienter med hypertension. Current Medical Research and Opinion 4 (Suppl. 2): 83 (1977).
Jauernig, R. and Moulds, R.F.W.: The use of isolated human arteries to study the action of prazosin and other hypotensive agents. Abstract of paper presented at Annual Meeting of Australasian Society of Clinical and Experimental Pharmacologists (November 1976).
Jauernig, R.A.; Moulds, R.F.W. and Shaw, J.: The action of prazosin in human vascular preparations. Archives Internationales de Pharmacodynamic et de Therapie 231: 81 (1978).
Kellaway, G.S.M.: Adverse drug reactions during treatment of hypertension. Drugs 11 (Suppl. 1): 91 (1976).
Kim, J.S.: A study of the use of prazosin in hypertensive patients in Korea. Clinical Science and Molecular Medicine 51: 45 (1976).
Kincaid-Smith, P.: Vasodilators in the treatment of hypertension. Medical Journal of Australia (Special Suppl) 1: 7 (1975).
Kincaid-Smith, Priscilla; Fang, P. and Laver, M.C.: A new look at the treatment of severe hypertension. Clinical Science and Molecular Medicine 45: 87S (1973).
Kincaid-Smith, Priscilla and Hua, A.: Beta-adrenergic blocking agents in renal failure. British Medical Journal 3: 520 (1974).
Kincaid-Smith, P.; Hua, A.S.P.; Myers, J.B.; Macdonald, I. and Fang, P.: Prazosin and hydrallazine in the treatment of hypertension. Paper presented at Symposium on Prazosin and Hypertension, Sydney, Melbourne and Auckland, Feb-Mar 1977.
Koshy, M.C.; Mickley, D.; Bourgoignie, J. and Blanfox, M.D.: Physiologic evaluation of a new antihypertensive agent: Prazosin HCl. Circulation 55: 533 (1977).
Kuokkanen, K. and Mattila, M.J.: Demonstration of an additive antihypertensive effect of prazosin and polythiazide in out-patients. Current Therapeutic Research 17: 431 (1975).
Lee, Y.W. and Seo, J.D.: A clinical study on antihypertensive effects of prazosin hydrochloride CMinipress’). Korean Circulation Journal 5: 25 (1975).
Lowenthal, D.T.; Shirk, J.; Affrime, M.B.; Busby, P.; Kim, K.E.; Fernandes, M.; Martinez, E.W.; Onesti, G. and Swartz, C.D.: Pharmacokinetics and effectiveness of prazosin in patients with chronic renal failure. Chnical Pharmacology and Therapeutics 23: 119 (1978).
Lübbe, W.F.: Prazosin in the therapy of uncontrolled hypertension. South African Medical Journal 52: 913 (1977).
Lund-Johansen, P.: Hemodynamic changes at rest and during exercise in long term prazosin therapy of essential hypertension; in Cotton (Ed) Prazosin — Evaluation of a new antihypertensive agent (Ex- cerpta Medica, Amsterdam, 1974).
Lund-Johansen, P.: Haemodynamic long-term effects of prazosin plus tolamolol in essential hypertension. British Journal of Clinical Pharmacology 4: 141 (1977).
Mabadeje, A.F.B,: An open trial of prazosin in the treatment of hypertension. Nigerian Medical Journal 8: 153 (1978).
Maher, P.H.: Clinical evaluation of prazosin in 20 private practice patients. Postgraduate Medicine (Suppl. Nov): 107 (1975).
Marshall, A.J.; Barritt, D.W.; Pocock, J. and Heaton, S.T.: Evaluation of beta-blockade, bendrofluazide, and prazosin in severe hypertension. Lancet 1: 271 (1977).
Martinez, E.W.; Fernandes, M.; Fiorentini, R.; Chandler, T.; Mazella, J.; Lowenthal, D.; Kim, K.E.; Swartz, C. and Onesti, G.: Effectiveness of the combination prazosin-propranolol-diuretic in refractory hypertension. Clinical Pharmacology and Therapeutics 23: 120 (1978).
Masoni, A.; Tommasi, A.M.; Baggioni, F. and Bagni, B.: Hemodynamic study in men of medium-term. treatment with a new amino-quinazoline antihypertensive agent (prazosin); in Cotton (Ed) Prazosin — Evaluation of a new antihypertensive agent (Excerpta Medica, Amsterdam 1974).
Massingham, R. and Hayden, M.L.: A comparison of the effects of prazosin and hydrallazine on blood pressure, heart rate and plasma renin activity in conscious renal hypertensive dogs. European Journal of Pharmacology 30: 121 (1975).
Maxwell, M.H.: Effects of prazosin on renal function and fluid-electrolyte metabolism. Postgraduate Medicine (Suppl. Nov): 36 (1975).
Melkild, A.: Behandling av hypertensjon med prazosin CPeripress’) alene og i kombinasjon med beta- blokker: en apen undersokelse hos polikliniske pasienter. Current Medical Research and Opinion 4 (Suppl. 2): 69 (1977).
Moyer, R.R.: Experience with prazosin in a clinical setting. Postgraduate Medicine (Suppl. Nov): 101 (1975).
Mroczek, W.J. and Finnerty, F.A. Jr: Prazosin — a double blind evaluation; in Cotton (Ed) Prazosin.— Evaluation of a new antihypertensive agent (Excerpta Medica, Amsterdam 1974).
Oates, H.F.; Graham, R.M.; Stoker, L.M. and Stokes, G.S.: Haemodynamic effects of prazosin. Archives internationales de pharmacodynamic et de therapie 224: 239 (1976).
Oates, H.F.; Graham, R.M. and Stokes, G.S.: Mechanism of the hypotensive action of prazosin. Archives Internationales de Pharmacodynamic et de Therapie 227: 41 (1977).
Oh, M.S.; Carroll, H.J.; Cruz, W.M.; Whang, E.S.M. and Lejano, R.F.: Treatment of hypertension with a combination of prazosin and polythiazide. Postgraduate Medicine (Suppl. Nov): 77 (1975).
Okun, R.: Dosage schedule routine for prazosin: two crossover trials comparing ti.d. with q.i.d. administration and t.i.d. and b.i.d. administration; in Cotton (Ed) Prazosin — Evaluation of a new antihypertensive agent (Excerpta Medica, Amsterdam 1974).
Onesti, G.; Fernandes, M.A.; Kim, K.E. and Swartz, C.D.: Prazosin in the treatment of hypertension. Clinical Pharmacology and Therapeutics 15: 216 (1974).
Oviasu, V.O. and Idahosa, P.E.: Variability in effect of low doses of prazosin in hypertensive Nigerians. Current Therapeutic Research 20: 757 (1976).
Pape, J.; Saltvedt, E.; Westiie, L.; Shetelig, A. and Fauchald, P.: Prazosin i behandling av refroktaer hypertensjon. Current Medical Research and Opinion 4(Suppl. 2): 89 (1977).
Paul, R.R.; Sharma, P.L. and Wahi, P.L.: A phase II study of prazosin hydrochloride in hypertensive subjects. International Journal of Clinical Pharmacology 14: 271 (1974).
Pitkajarvi, T.; Kyostila, S.; Kontro, J. and Mattila, M.J.: Antihypertensive action of drug combination: polythiazide, prazosin and tolamolol. Current Therapeutic Research 21: 169 (1977).
Pitts, N.E.: The clinical evaluation of prazosin a new antihypertensive agent. Postgraduate Medicine (Suppl. Nov): 117 (1975).
Piza Lopez, A. and Gutierrez Fuster, E.: Study on the efficacy and tolerance of a new antihypertensive drug prazosin hydrochloride. Comparison with a-methyldopa. Investigacion Medica Intemacional 3: 163 (1975).
Rab, S.M. and Farooqui, S.: Prazosin in the treatment of hypertension — a preliminary report. British Journal of Clinical Practice 29 (12): 337 (1975).
Raftos, J.: The difficult hypertensive. Drugs 11:55 (1976).
Rand, M.J.; McCulloch, M.W. and Story, D.F.: Pre-junctional modulation of noradrenergic transmission by noradrenaline, dopamine and acetylcholine; in Davies and Reid (Eds) Central Action of Drugs in the Regulation of Blood Pressure (Pitman Medical, London 1975).
Rasmussen, K. and Jensen, H.A.: Prazosin in treatment of hypertension. British Medical Journal 4: 346 (1975).
Rasmussen, K. and Jensen, H.A.E.: A cross-over study between hydrallazine and prazosin. Clinical Science and Molecular Medicine 51: 612S (1976).
Rasmussen, K. and Jensen, H.A.: Prazosin og hydralazin: Ackvipotente antihypertensive doser i Kom- binations-behandling med propranolol. Current Medical Research and Opinion 4(Suppl. 2): 77 (1977).
Rees, J. and Williams, H.:- Adverse reactions to prazosin. British Medical Journal 3: 593 (1975).
Research Group, Japan.: Open studies with prazosin in the treatment of essential hypertension. Medical Journal of Australia 2(Suppl.): 38 (1977).
Reyes, A.L.: Prazosin; some clinical observations in ambulatory hypertensive patients. Philippine Journal of Cardiology 2: 30 (1974).
Roach, A.G.; Lefevre, F. and Cavero, I.: Effects of prazosin and phentolamine on cardiac presynaptic a- adrenoceptors in the cat, dog and rat. Clinical and Experimental Hypertension 1: 87 (1978).
Rosendorf T C.: Prazosin: severe side-effects are dose dependent. British Medical Journal 3: 508 (1976).
Rougier, M.; Lahon, H.F.J.; Clini, A.R.: Prazosin — a new antihypertensive agent. British Journal of Clinical Practice 28: 280 (1974).
Safar, M.E.; Weiss, Y.A.; London, G.L. and Milliez, P.L.: Short-term hemodynamic studies with prazosin; in Cotton (Ed) Prazosin — Evaluation of a new antihypertensive agent (Excerpta Medica, Amsterdam 1974).
Salim, S.S.; Mtui, E.P.J. and Makene, W.J.: An open evaluation of the efficacy and toleration of prazosin in patients with hypertension. East African Medical Journal 54: 429 (1977).
Schnaper, H.W. and Oberman, A.: Double-blind studies of the clinical effectiveness of prazosin. Postgraduate Medicine (Suppl. Nov): 81 (1975).
Schirger, A. and Sheps, S.G.: Prazosin — a new antihypertensive agent A double-blind crossover study in the treatment of hypertension. Journal of the American Medical Association 237: 989 (1977).
Scivoletto, R.; Toledo, A.J.O.; Gomes da Silva, A.C. and Nigro, D.: Mechanism of the hypotensive effect of prazosin. Archives internationales de pharmacodynamie et de therapie 223: 333 (1976).
Seedat, Y.K.: Treatment of hypertension with the aid of beta-adrenergic blocking drugs. South African Medical Journal 48: 846 (1975).
Seedat, Y.K.: Bhoola, R. and Rampono, J.G.: Prazosin in treatment of hypertension. British Medical Journal 3: 305 (1975b).
Seedat, Y.K.; North-Coombes, D. and Rampono, J.G.: Prazosin in the treatment of hypertension. South African Medical Journal Mediese Tydskrif 49: 1741 (1975a).
Seedat, Y.K.; Seedat, M.A. and Bhoola, R.: Prazosin alone and combined with a thiazide diuretic in the treatment of hypertension. South African Medical Journal 51: 461 (1977).
Simpson, F.O.: Some aspects of the pharmacology of prazosin and their clinical implications. Medical Journal of Australia 2 (Suppl.): 7 (1977).
Simpson, F.O.; Bolli, P. and Wood, J.: Use of prazosin at the Dunedin hypertensive clinic. Controlled and open studies and pharmacokinetic observations. Medical Journal of Australia 2 (Suppl.): 17 (1977).
Smith, I.S.; Fernandes, M.; Kim, K.E.; Swartz, C. and Onesti, G.: A three-phase clinical evaluation of prazosin. Postgraduate Medicine (Suppl. Nov): 53 (1975).
Steele, J.M. and Lowenstein, J.: Absence of renin stimulation of tachycardia during antihypertensive therapy with prazosin. Presented at the 4th meetings of the International Society of Hypertension, Sydney (February, 1976).
Stokes, G.S.; Gain, J.M.; Mahony, J.F.; Stewart, J.H. and Raftos, J.: Lx)ng-term use of prazosin in combination or alone for treating hypertension. Medical Journal of Australia 2 (Suppl.): 13 (1977a).
Stokes, G.S.; Graham, R.M.; Gain, J.M. and Davis, P.R.: Influence of dosage and dietary sodium on the first-dose effects of prazosin. British Medical Journal 1: 1507 (1977).
Stokes, G.S. and Oates, H.F.: Comparative and interaction studies with peripherally-acting hypotensive agents. Special supplement to the Medical Journal of Australia 2: 9 (1977b).
Stokes, G.S. and Weber, M.A.: Prazosin: preliminary report and comparative studies with other antihypertensive agents. British Medical Journal 2: 298 (1974).
Taylor, J.A.; Twomey, T.M. and Schach von Wittenau, M.: The metabolic fate of prazosin. Xenobiotica. In press (1976).
Thulin, J.A.; Saetre, H.; Vikesdahl, O.; Warmenius, S.; Persson, G. and Schersten, B.: Multicenter study of the antihypertensive effects of prazosin hydrochloride (prazosin) on mild and moderate hypertension; in Cotton (Ed) Prazosin — Evaluation of a new antihypertensive agent (Excerpta Medica, Amsterdam 1974).
Turner, A.S.: Prescribing prazosin. New Zealand Medical Journal 84: 31 (1976a).
Turner, A.S.: Prazosin in hypertension. British Medical Journal 2: 1257 (1976b).
Turner, A.S.; Watson, O.F. and Brocklehurst, J.E.: Prazosin in hypertension. Clinical studies with special reference to initiation of therapy. Medical Journal of Australia 2 (Suppl.): 33 (1977).
Turner, A.S.; Watson, O. and Peel, J.S.: Clinical experience with prazosin hydrochloride in arterial hypertension. New Zealand Medical Journal 81: 240 (1975).
Venables, T.L. and Duff, R.S.: A comparative trial of prazosin and methyldopa; in Cotton (Ed) Prazosin — Evaluation of a new antihypertensive agent (Excerpta Medica, Amsterdam 1974).
Verbesselt, R.; Mullie, A.; Tjandramaga, T.B.; De Schepper, P.J. and Dessain, P.: The effect of food intake on the plasma kinetics and toleration of prazosin. Acta Therapeutica 2: 27 (1976).
Verhiest, W.; Croonenberghs, J.; Devos, P.; Fagard, R. and Amery, A.: Double-blind cross-over study comparing prazosin and methyldopa in the treatment of mild hypertension. Acta Cardiologica 29: 217 (1974).
Vyrens, R. and Adriaensen, H.: Double-blind croover comparative study with low doses of prazosin and a-methyldopa; in Cotton (Ed) Prazosin — Evaluation of a new antihypertensive agent (Excerpta Medica, Amsterdam 1974).
Wood, A.J.: Pharmacokinetics of prazosin in man. Presented to the Annual Meeting of the Australasian Society of Clinical and Experimental Pharmacologists, December 1974; see also Clinical and Experimental Pharmacology and Physiology 2: 446 (1975).
Wood, A.J.; Bolli, B. and Simpson, P.O.: Prazosin in normal subjects: plasma levels, blood pressure and heart rate. British Journal of Clinical Pharmacology 1: 199 (1976).
Wood, AJ. and Lee, D.R.: Effects of prazosin on sodium and body fluids in genetically hypertensive rats. Proceedings of the University of Otago Medical School 52: 12 (1974).
Wood, A.J.; Phelan, E.L. and Simpson, P.O.: Cardiovascular effects of prazosin in normotensive and genetically hypertensive rats. Clinical and Experimental Pharmacology and Physiology 2: 297 (1975).
Zapala, H.H. and Bengolea, A.M.: Clinical experience with prazosin in essential blood hypertension therapy (translation). Prensa Medica Argentina 60: 1227 (1973).
Editor information
Rights and permissions
Copyright information
© 1979 ADIS Press
About this chapter
Cite this chapter
Brogden, R.N., Heel, R.C., Speight, T.M., Avery, G.S. (1979). Prazosin: A Review of its Pharmacological Properties and Therapeutic Efficacy. In: Brogden, R.N. (eds) Antihypertensive Drugs Today. Cardiovascular Drugs, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7268-4_4
Download citation
DOI: https://doi.org/10.1007/978-94-011-7268-4_4
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-7270-7
Online ISBN: 978-94-011-7268-4
eBook Packages: Springer Book Archive