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The peri-menopause at the cellular level

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The Controversial Climacteric

Abstract

There were several possible ways of dealing with the subject of this workshop. The central theme finally chosen was the mechanism of action of steroid hormones, attention being paid not only to oestrogens, but also to progestational substances. The questions raised at the beginning of the session were:

  1. (1)

    What do we know about the way in which steroids act at the cellular level?

  2. (2)

    What do we know about the handling in vivo of oestrogens by target tissues in post-menopausal women?

  3. (3)

    Is it possible to identify and to quantitate specific effects of steroid interactions with tissues?

  4. (4)

    Are we able to relate some of these specific effects to clinically important events?

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Bibliography

  • King, R. J. B., Whitehead, M. I., Campbell, S. and Minardi, J. (1979). Effect of estrogen and progestin treatments on endometria from postmenopausal women. Cancer Res., 39, 1094

    PubMed  CAS  Google Scholar 

  • Müller, R. E. and Wotiz, H. H. (1979). Kinetics of estradiol entry into uterine cells. Endocrinology, 105, 1107

    Article  PubMed  Google Scholar 

  • Pasqualini, J. R., Gulino, A., Nguyen, B. L. and Portois, M. C. (1980). Receptor and biological response to estriol in the fetal uterus of guinea pig./ Receptor Res., 1, 261

    CAS  Google Scholar 

  • Sutherland, R. L. and Murphy, L. C. (1980). The binding of tamoxifen to human mammary carcinoma cytosol. Eur. J. Cancer, 16, 1141

    PubMed  CAS  Google Scholar 

  • Thijssen, J. H. H., Wiegerinck, M. H. A. M., Mulder, G. and Poortman, J. (1978). On the biological activity of estrone in vivo. In Lauritzen, C. and van Keep, P. A. (eds.) Estrogen Therapy — the Benefits and Risks. Front. Hormone Res., Vol. 5, pp. 220–229. ( Basel: Karger )

    Google Scholar 

  • Tseng, L. (1980). Hormonal regulation of steroid metabolic enzymes in human endometrium. In Thomas, J. A. and Singhai, R. L. (eds.) Advances in Sex Hormone Research. Vol. IV, pp. 329–361 ( Baltimore and Munich: Urban and Schwarzenberg )

    Google Scholar 

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© 1982 MTP Press Limited

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van Keep, P.A., Utian, W.H., Vermeulen, A. (1982). The peri-menopause at the cellular level. In: van Keep, P.A., Utian, W.H., Vermeulen, A. (eds) The Controversial Climacteric. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7253-0_10

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  • DOI: https://doi.org/10.1007/978-94-011-7253-0_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-7255-4

  • Online ISBN: 978-94-011-7253-0

  • eBook Packages: Springer Book Archive

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