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Steroid-induced Changes in the Endometrium of Postmenopausal Women

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The Menopause and Postmenopause

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Abstract

The controversy over the putative carcinogenic effects of estrogens on the human endometrium1–3 can only be resolved by multidisciplinary studies which elucidate the effects of female sex hormones on the human endometrium. Retrospective analysis of epidemiologic data4,5 has provided the basis for our current concern about the administration of estrogen to postmenopausal women. Histological and clinical observations from prospective studies have reinforced the view that estrogens should not be given alone over long periods and that for at least 7 and perhaps 10 days each month a progestin should be added to the estrogen therapy6–8. The third facet of such a multidisciplinary approach would be to study the biochemistry of endometria from women receiving different combinations of female sex hormones.

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Authors
  1. R. J. B. King
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  2. P. T. Townsend
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  3. M. I. Whitehead
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Editor information

Editors and Affiliations

  1. Cattedra di Patologia Ostetrica e Ginecologica, Univeristà di Roma, V. le Regina Elena, 324-00161, Roma, Italy

    N. Pasetto

  2. Istituto di Farmacologia, Università di Milano, Via Vanvitelli, 32-Milano, Italy

    R. Paoletti

  3. Department of Health, State of New York, Roswell Park Memorial Institute, 14263, Buffalo, New York, USA

    J. L. Ambrus

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© 1980 MTP Press Limited

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King, R.J.B., Townsend, P.T., Whitehead, M.I. (1980). Steroid-induced Changes in the Endometrium of Postmenopausal Women. In: Pasetto, N., Paoletti, R., Ambrus, J.L. (eds) The Menopause and Postmenopause. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7230-1_21

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  • DOI: https://doi.org/10.1007/978-94-011-7230-1_21

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-7232-5

  • Online ISBN: 978-94-011-7230-1

  • eBook Packages: Springer Book Archive

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