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Chemistry and Biochemistry of Natural Estrogens

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The Menopause and Postmenopause

Abstract

A very large number of substances are known to possess estrogenic activity1 as defined by certain biological effects, usually growth and development, on target tissues and organs related to reproductive function in the female.

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References

  1. Deghenghi, R. and Givner, M. L. (1979). The female sex hormones and analogs. Burger’s Medicinal Chemistry, 4th Ed., pp. 917–939

    Google Scholar 

  2. Teller, M. N., Stock, C. C., Borie, M. and McMahon, S. (1979). Resorcylic acid lactones: new compounds active against DMBA-induced rat mammary carcinomas. Am. Assoc. Cancer Res. Annual Meeting, May 16–19, New Orleans

    Google Scholar 

  3. Stern, M. D. and Givner, M. L. (1978). Studies on the mechanism of action of conjugated equine estrogens. Endometrial Cancer, pp. 309–322 ( London: Baillière Tindall )

    Google Scholar 

  4. Eisenfeld, A. J., Aten, R., Weinberger, M., Haselbacher, G., Halpern, K. and Krakoff, L. (1976). Estrogen receptor in the mammalian liver. Science, 191, 862

    Article  PubMed  CAS  Google Scholar 

  5. Ménard, J., Corvol, P., Foliot, A. and Raynaud, J. P. (1973). Effects of estrogens on renin substrate and uterine weights in rats. Endocrinology, 93, 747

    Article  PubMed  Google Scholar 

  6. Furman, R. H., Alanpovic, P. and Howard, R. P. (1967). Effects of androgens and estrogens on serum lipid and the composition and concentration of serum lipoprotein in normal normolitemic and hyperlipidemic states. Prog. Biochem. Pharmacol., 2, 215–249

    CAS  Google Scholar 

  7. Wallace, R. B., Hoover, J., Sandler, D., Rifkind, B. M. and Tyroler, H. A. (1977). Altered plasma-lipids associated with oral contraceptive or estrogen consumption. Lancet, 11, 11

    Article  Google Scholar 

  8. Barrett-Connor, E., Brown, V., Turner, J., Austin, M. and Criqui, M. H. (1979). Heart disease risk factors and hormone use in postmenopausal women. J. Am. Med. Assoc., 241, 2167

    Article  CAS  Google Scholar 

  9. Glueck, C. J., Fallat, R. W. and Scheel, D. (1975). Effects of estrogenic compounds on triglyceride kinetics. Metabolism, 24, 537

    Article  PubMed  CAS  Google Scholar 

  10. Donde, U. M. and Virkar, K. (1975). Effect of contraceptive steroids on serum lipids. Am. J. Obstet. Gynecol., 123, 736

    PubMed  CAS  Google Scholar 

  11. Loeper, J., Loeper, J., Ohlghiesser, C., de Lignières, B. and Mauvais-Jarvis, P. (1977). Influence de l’estrogènothérapie sur les triglycérides. Nouv. Presse Méd., 6, 2747

    PubMed  CAS  Google Scholar 

  12. Buckman, M. T., Johnson, J., Ellis, H., Srivastava, L. and Peake, G. T. (1979). Lipemic and proteinemic effect of estrogen is dependent on route of estrogen administration. Endocrine Society 61st Annual Meeting, Abstr. 956

    Google Scholar 

  13. Bolton, C. H., Ellwood, M., Hartog, M., Martin, R., Rowe, A. S., Wensley, R. T. (1975). Comparison of the effects of ethinyl estradiol and conjugated equine estrogens in oophorectomized women. Clin. Endocrinol., 4, 131

    Article  CAS  Google Scholar 

  14. Hill, P. and Dvornik, D. (1969). Estrogen-induced hypertriglyceridemia in female rats. Circulation, Suppl. III to 39 and 40, 106

    Google Scholar 

  15. Yen, S. S. C., Vandenberg, G. and Siler, T. M. (1974). Modulation of pituitary responsiveness to LRF by estrogen. J. Clin. Endocrinol. Metab., 39, 170

    Article  PubMed  CAS  Google Scholar 

  16. Wiedemann, E., Schwartz, E. and Frantz, A. G. (1976). Acute and chronic estrogen effects upon serum somatomedin activity, growth hormone, and prolactin in man. J. Clin. Endocrinol. Metab., 42, 942

    Article  PubMed  CAS  Google Scholar 

  17. Kandeel, F., Butt, W. R. and London, D. R. (1977). Regulation of serum prolactin by estrone and estrone sulfate in normally menstruating women. Acta Endocrinol., 212 (Suppl.), 42

    Google Scholar 

  18. L’Hermite, M., Delogne-Desnoeck, J., Michaux-Duchene, A. and Robyn, C. (1978). Alteration of feedback mechanism of estrogen on gonadotropin by sulpiride-induced hyperprolactinemia. J. Clin. Endocrinol. Metab., 47, 1132

    Article  PubMed  Google Scholar 

  19. Von Kaulla, E., Droegemueller, W. and Von Kaulla, K. N. (1975). Conjugated estrogens and hypercoagulability. Am. J. Obstet. Gynecol., 122, 688

    Google Scholar 

  20. Notelovitz, M. and Greig, H. B. W. (1976). Natural estrogen and anti-thrombin III activity in postmenopausal women. J. Reprod. Med., 16, 87

    Google Scholar 

  21. Notelovitz, M. and Greig, H. B. W. (1975). The effect of natural estrogens on coagulation. S. Afr. Med. J., 49, 101

    PubMed  CAS  Google Scholar 

  22. Fedor-Freybergh, P. (1977). The influence of estrogens on the well-being and mental performance in climacteric and postmenopausal women. Acta Obstet. Gynecol. Scand., 64 (Suppl.), 1

    CAS  Google Scholar 

  23. Thomson, J. and Oswald, I. (1977). Effect of estrogen on the sleep, mood and anxiety of menopausal women. Br. Med. J., 2, 1317

    Article  PubMed  CAS  Google Scholar 

  24. La Bella, F. S., Kim, R. S. and Templeton, J. (1978). Opiate receptor binding activity of 17a-estrogenic steroids. Life Sci., 23, 1797

    Article  Google Scholar 

  25. Pugsley, T. and Lippmann, W. (1978). Effect of somatostatin analogues and 17a-dihydroequilin on rat brain opiate receptors. Res. Commun. Chem. Pathol. Pharmacol., 21, 153

    PubMed  CAS  Google Scholar 

  26. Adlercreutz, H., Martin, F., Pulkkinen, M., Dencker, H., Rimer, U., Sjöberg, N.-O. and Tikkanen, M. J. (1976). Intestinal metabolism of estrogens. J. Clin. Endocrinol. Metab., 43, 497

    Article  PubMed  CAS  Google Scholar 

  27. Yen, S. S. C., Martin, P. L., Burnier, A. M., Czekala, N. M., Greaney, M. O. Jr. and Callantine, M. R. (1975). Circulating estradiol, estrone and gonadotropin levels following the administration of orally active l7ß-estradiol in postmenopausal women. J. Clin. Endocrinol. Metab., 40, 518

    Article  PubMed  CAS  Google Scholar 

  28. Englund, D. E. and Johansson, E. D. B. (1977). Pharmacokinetic and pharmacodynamic studies on estradiol valerianate administered orally to postmenopausal women. Acta Obstet. Gynecol. Scand., 65 (Suppl.), 27

    Article  CAS  Google Scholar 

  29. Englund, D. E. and Johansson, E. D. B. (1978). Plasma levels of estrone, estradiol and gonadotrophins in postmenopausal women after oral and vaginal administration of conjugated equine estrogens (Premarin). Br. J. Obstet. Gynaecol., 85, 957

    Article  PubMed  CAS  Google Scholar 

  30. Schiff, I., Tulchinsky, D. and Ryan, K. J. (1977). Vaginal absorption of estrone and l7ß-estradiol. Fertil. Steril., 28, 1063

    PubMed  CAS  Google Scholar 

  31. Rigg, L. A., Hermann, H. and Yen, S. S. C. (1978). Absorption of estrogens from vaginal creams. N. Engl. J. Med.,298, 195

    Article  PubMed  CAS  Google Scholar 

  32. Horwitz, R. I. and Feinstein, A. R. (1979). Intravaginal estrogen creams and endometrial cancer. J. Am. Med. Assoc., 241, 1266

    Article  CAS  Google Scholar 

  33. Zondek, B. (1929). Folliculin. Klin. Wochensch., 142, 895

    Google Scholar 

  34. Tresca, J.-P., Ponsard, G. and Jayle, M.-F. (1977). Cinétiques de pénétration transcutanée et de fixation du 3-propyl éther, 17-méthyl éther estradiol et de l’estradiol au niveau de différents tissus chez la ratte. Canad. J. Biochem., 55, 1096

    Article  CAS  Google Scholar 

  35. Goldzieher, J. W. and Baker, R. E. (1960). The percutaneous absorption of estradiol and progesterone. J. Invest. Dermatol., 35, 215

    PubMed  CAS  Google Scholar 

  36. Wepierre, J. and Marty, J. P. (1979). Percutaneous absorption of drugs. TIPS — Trends in Pharm. Sei. (inaugural issue), p. 23

    Google Scholar 

  37. Adams, W. P., Johnson, R. N., Hasegawa, J. and Haring, R. C. (August 1979). Conjugated estrogens bioinequivalence — a comparison of four products in postmenopausal women. J. Pharm. Sei. (in press)

    Google Scholar 

  38. Needham, J. and Gwei-Djen, L. (1968). Sex hormones in the Middle Ages. Endeavour, 27, 130

    PubMed  CAS  Google Scholar 

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Deghenghi, R. (1980). Chemistry and Biochemistry of Natural Estrogens. In: Pasetto, N., Paoletti, R., Ambrus, J.L. (eds) The Menopause and Postmenopause. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7230-1_1

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  • DOI: https://doi.org/10.1007/978-94-011-7230-1_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-7232-5

  • Online ISBN: 978-94-011-7230-1

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