Abstract
The implications of genetics in mental handicap are so far-reaching that within the space of a single chapter it is impossible to achieve more than an outline of the underlying principles of genetic causation and a review of their practical application. Aspects which merit particular attention have been selected; these include the need for accurate diagnosis, the interpretation to parents of degree of genetic risk, problems and hazards in genetic counselling and the vital matter of the initial disclosure to parents of the diagnosis of a genetic condition. Prenatal diagnosis of genetic conditions is of special significance in connection with mental handicap, and its positive aspects, besides its value as a tool in preventive medicine, are discussed.
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References
Berg, J. and Kirman, B. H. (1959). Some aetiological problems in mental deficiency. Br. Med. J., 2, 848
Canadian Research Council (1977). Diagnosis of Genetic Disease by Amniocentesis during the Second Trimester of Pregnancy. Report No. 5. (Ottawa: Ministry of Supplies and Services)
Carter, C. O. (1971). Genetic counselling. In Berg, J. M. (ed.) Genetic Counselling in Relation to Mental Retardation. Symposium No. 2. Institute for Research into Mental Retardation. (Oxford: Pergamon Press)
Carter, C. O. and Roberts, J. A. F. (1967). The risk of recurrence after two children with central nervous system malformations. Lancet, 1, 306
Carter, C. O. and MacCarthy, D. (1951). Incidence of mongolism and its diagnosis in the newborn. Br. J. Soc. Med., 5, 83
Cowie, V. A. (1966). Genetic Counselling. Proc. Roy. Soc. Med., 59, 149
Cowie, V. A. (1977). Genetic counselling clinics. In Raine, D. N. (ed.) Medico-Social Management of Inherited Metabolic Disease. A monograph derived from the Thirteenth Symposium of the Society for the Study of Inborn Errors of Metabolism, pp. 103–117. (Lancaster: MTP)
Cowie, V. A., Eckstein, H. and Colliss, V. (1975). Unpublished data
Drillien, C. M. and Wilkinson, E. M. (1964). Mongolism: when should parents be told? Br. Med. J., 2, 1306
Duncan, S. L. B. (1978). Problems of pre-natal screening programme for Down’s syndrome in older women. J. Biosoc. Sci., 10, 141
Editorial, British Medical Journal (1977). Diagnostic amniocentesis in early pregnancy. Br. Med. J., 1, 1430
Emery, A. E. H. (1975). Genetic counselling. Br. Med. J., ii, 219
Gerbie, A. B., Nadler, H. L. and Gerbie, M. M. (1971). Amniocentesis in genetic counselling. Safety and reliability in early pregnancy. Am. J. Obstet. Gynecol, 109, 765
Kalbac, R. W. and Newman, R. L. (1974). Amniotic fluid analysis in complicated pregnancies. Obstet. Gynecol, 44, 814
McBean, S. (1971). The problems of parents of children with phenylketonuria. In Bichei, H., Hudson, F. P. and Woolf, L. I. (eds.) Phenylketonuria and Some Other Inborn Errors of Amino-Acid Metabolism, pp. 280–2. (Stuttgart: Thième)
Polani, P. E. (1977). (Personal communication)
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© 1980 The British Institute of Mental Handicap
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Cowie, V.A. (1980). Genetics and Mental Handicap. In: Simon, G.B. (eds) The Modern Management of Mental Handicap. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7200-4_3
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DOI: https://doi.org/10.1007/978-94-011-7200-4_3
Publisher Name: Springer, Dordrecht
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