Abstract
The debate over the dual function of prostaglandins (PGs) in inflammatory conditions is continuing with unremitting vehemence1. Recent data2 indicate that a pivotal pro-inflammatory mediator role may be exerted by the cyclic endoperoxide PGG2, although PG itself is also pro-inflammatory, since it potentiates the acute inflammatory effect of other mediators3. The suggestions concerning the anti-inflammatory function of PGE were born out of in vitro studies, which have shown that PGE-mediated elevation of intracellular cyclic-AMP (cAMP) prevents the release of lysosomal enzymes from PMN leukocytes and the discharge of lymphokines from T-lymphocytes4-6. The inhibitory effect of PGE on the synthesis of collagen is another in vitro observation7 which supports a possible anti-inflammatory function. Furthermore, pharmacological doses of PGE were shown, in vivo, to inhibit granuloma formation, when applied locally into an implanted foreign body8 and to suppress the adjuvant-induced arthritis of rats9,10.
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References
Willoughby, D. A. and Dieppe, P. (1976). Prostaglandins in the inflammatory response -pro or anti? In: The Role of Prostaglandins in Inflammation ( G. P. Lewis, ed.) pp. 14–25. ( Bern-Stuttgart-Vienna: Hans Haber Publishers )
Kuehl, F. A., Humes, J. L., Egan, R. W., Ham, E. A., Beveridge, G. C. and van Arman, C. G. (1977). Role of prostaglandin endoperoxide PGG2 in inflammatory processes, Nature (London) 265, 170
Moncada, S., Ferreira, S. H. and Vane, J. R. (1973). Prostaglandins, aspirin-like drugs and the oedema of inflammation. Nature (London), 246, 217
Bourne, H. R., Lichtenstein, L. M. and Melmon, K. L. (1972). Pharmacologic control of allergic histamine release in vitro: evidence for an inhibitory role of 3’,5’-adenosine monophosphate in human leukocyte. J. Immunol., 108, 695
Boume, H. R., Lichtenstein, L. M., Melmon, K. L., Henney, C. S., Weinstein, Y. and Shearer, G. M. (1974). Modulation of inflammation and immunity by cyclic AMP. Science, 184, 19
Gordon, D., Bray, M. A. and Morley, J. (1976). Control of lymphokine secretion by prostaglandins, Nature (London), 262, 401
Raisz, L. G. and Koolemans-Beijnen, A. R. (1974). Inhibition of bone collagen synthesis by prostaglandin E2 in organ culture. Prostaglandins, 8, 377
DiPasquale, G., Rassaert, C., Richter, R., Welaj, P. and Tripp, L. (1973). Influence of prostaglandins (PG) E2 and Fen on the inflammatory process. Prostaglandins, 3, 741
Aspinall, R. L. and Cammarata, P. S. (1969). Effect of prostaglandin E2 on adjuvant arthritis. Nature (London), 224, 1320
Zurier, R. B., Hoffstein, S. and Weissmann, G. (1973). Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prosta- glandins. Arthritis. Rheum., 16, 609
Vane, J. R. (1971). Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol, 231, 232
Vane, J. R. (1973). Inhibition of prostaglandin biosynthesis as the mechanism of action of aspirin-like drugs. In: Advances in the Biosciences ( S. Bergström and S. Bernhard, eds.) Vol. 9, pp. 395–411. ( Oxford: Pergamon Press )
Brocklehurst, W. E. and Dawson, W. (1974). New data concerning the inhibition of prostaglandin formation by anti-inflammatory drugs. In: Future Trends in Inflammation II ( G. P. Velo, D. A. Willoughby and J.-P. Giroud, eds.) pp. 37–43. ( Padua: Piccin Medical Books )
Smith, M. J. H. (1975). Prostaglandins and aspirin: An alternative view. Agents Actions, 5, 315
Bonta, I. L., Bult, H., Vincent, J. E. and Zijlstra, F. J. (1977). Acute anti-inflammatory effects of aspirin and dexamethasone in rats deprived of endogenous prostaglandin precursors. J. Pharm. Pharmacol., 29, 1
Ziboh, V. A., Vanderhoek, J. Y. and Lands, W. E. M. (1974). Inhibition of sheep vesicular gland oxygenase by unsaturated fatty acids from skin of essential fatty acid deficient rats. Prostaglandins, 5, 233
Bult, H. and Bonta, I. L. (1976). Rat platelets aggregate in the absence of endogenous precursors of prostaglandin endoperoxides, Nature (London), 264, 449
Bonta, I. L., Chrispijn, H., Noordhoek, J. and Vincent, J. E. (1974). Reduction of prostaglandin phase in hind-paw it inflammation and partial failure of indomethacin to exert anti-inflammatory effect in rats on essential fatty acid deficient diet. Prostaglandins, 5, 495
Denko, C. W. (1974). Effect of prostaglandins in urate crystal inflammation. Pharmacology, 12, 331
Bonta, I. L., Bult, H., van der Ven, L. L. M. and Noordhoek, J. (1976). Essential Fatty Acid Deficiency: A condition to discriminate prostaglandin and non-prostaglandin mediated components of inflammation. Agents Actions, 6, 154
Vincent, J. E., Zijlstra, F. J. and Bonta, I. L. (1975). The effect of non-steroid anti-inflammatory drugs, dibutyryl cyclid 3’,5’-adenosine monophosphate and phosphodiesterase inhibitors on platelet aggregation and the platelet release reaction in normal and essential fatty acid deficient rats. Prostaglandins, 10, 899
Kulonen, E. and Potila, M. (1975). Effect of the administration of antirheumatic drugs on experimental granuloma in rat. Biochem. Pharmacol., 24, 219
Denko, C. W. (1976). 35S and 3H-proline incorporation in rats deficient in essential fatty acids. J. Rheumatol., 3, 205
Denko, C. W. (1976). Modification of adjuvant inflammation in rats deficient in essential fatty acids. Agents Actions, 6, 636
Hayashida, T. and Portman, O. W. (1959). Effects of essential fatty acid deficiency on rat adrenal composition and secretory activity. Am. J. Physiol., 197, 893
Parnham, M. J. (1977). Metyrapone: A possible tool in investigating the role of endogenous corticosteroids in inflammation. Agents Actions Suppl. issue (In press)
Bonta, I. L., Parnham, M. J., van Vliet, L. and Vincent, J. E. (1977). Mutual enhancement of the effects of prostaglandin E1 and theophylline on the Freund adjuvant-induced arthritis syndrome of rats. Br. J. Pharmacol., 59, 438 p
Adolfs, M. J. P., Bonta, I. L. and Parnham, M. J. (1977). Cyclic AMP production during adjuvant-induced arthritis in rats. Br. J. Pharmacol., 59, 439r
Parnham, M. J., Bonta, I. L. and Adolfs, M. J. P. (1977). Interactions between prostaglandin E and cyclic nucleotides in chronic inflammatory disease. In: Perspectives in Inflammation (D. A. Willoughby, J.-P. Giroud and G. P. Velo) pp. 279–287. ( London: MTP Press Limited )
Holman, R. T. (1971). In: Progress in the Chemistry of Fats and Other Lipids (R. T. Holman, ed.) p. 275. ( Oxford: Pergamon Press )
Morley, J. (1977). Interaction between lymphocytes and macrophages. Agents Actions Suppl. issue (In press)
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Bonta, I.L., Parnham, M.J., Adolfs, M.J.P., van Vliet, L. (1977). Dual function of E-type prostaglandins in models of chronic inflammation. In: Willoughby, D.A., Giroud, J.P., Velo, G.P. (eds) Perspectives in Inflammation. Future Trends in Inflammation, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7185-4_19
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DOI: https://doi.org/10.1007/978-94-011-7185-4_19
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