Abstract
There are extremely limited data available concerning concentrations, physiology and pathophysiology of gonadotrophin releasing factors in the menopause. One may summarize existing data as follows:
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1.
The concentrations in blood (and presumably secretion) of LH and FSH in menopausal women are pulsatile with cyclic variation at 10–20 min intervals.
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2.
In response to administration of the decapeptide LHRH (Luteinizing Hormone Releasing Hormone) to menopausal women, more LH is secreted than FSH when the two are stated in comparable terms, i.e., as increments above base line or in terms of the 2nd. IRP-HMG.
Yet, during the basal menopausal state FSH concentrations are always higher than LH concentrations when stated in the same terms.
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3.
LHRH has been said to be present in larger amounts in blood of post-menopausal women than in eugonadal men or women.
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© 1976 MTP Press Limited
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Odell, W.D., L’Hermite, M. (1976). Releasing Factors in the Menopause. In: van Keep, P.A., Greenblatt, R.B., Albeaux-Fernet, M. (eds) Consensus on Menopause Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7179-3_3
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DOI: https://doi.org/10.1007/978-94-011-7179-3_3
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-7181-6
Online ISBN: 978-94-011-7179-3
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