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Cuprous-Thiolate Polymetalic Clusters in Biology

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Book cover Bioinorganic Chemistry of Copper

Abstract

Copper-sulfur (CuS) multinuclear clusters exist in biological macromolecules that function in a variety of cellular processes ranging from copper ion buffering, signal transduction to copper ion storage. The sulfur ligands are typically provided exclusively by cysteinyl thiolates and proteins and peptides containing CuS clusters have an abundance of cysteine residues. A common sequence motif in these polypeptides is Cys-Xaa-Cys or Cys-Xaa-Xaa-Cys in which Xaa represents any other amino acid.

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Author information

Authors and Affiliations

  1. Departments of Medicine and Biochemistry, University of Utah Medical Center, Salt Lake City, UT, 84132, USA

    D. R. Winge & C. T. Dameron

  2. Stanford Synchrotron Radiation Laboratory, Stanford University, P.O. Box 4349 Bin 69, Stanford, CA, 94309, UK

    G. N. George & I. J. Pickering

  3. School of Chemistry, University of New South Wales, Kensington, N.S.W., 2033, Australia

    I. G. Dance

Authors
  1. D. R. Winge
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  2. C. T. Dameron
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  3. G. N. George
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  4. I. J. Pickering
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  5. I. G. Dance
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Editors and Affiliations

  1. The Johns Hopkins University, USA

    Kenneth D. Karlin  & Zoltán Tyeklár  & 

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Winge, D.R., Dameron, C.T., George, G.N., Pickering, I.J., Dance, I.G. (1993). Cuprous-Thiolate Polymetalic Clusters in Biology. In: Karlin, K.D., Tyeklár, Z. (eds) Bioinorganic Chemistry of Copper. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6875-5_9

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  • DOI: https://doi.org/10.1007/978-94-011-6875-5_9

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