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Structure and Reactivity of Copper-Containing Amine Oxidases

  • Chapter
Bioinorganic Chemistry of Copper

Abstract

In recent years, considerable progress has been made toward understanding the active site structures and mechanisms of copper-containing amine oxidases. Copper-containing amine oxidases are one of the most widely distributed classes of “Type-2” copper enzyme. Copper amine oxidases have been highly purified from bacteria, yeasts, plants, and mammals.1 Recently an inducible phenethylamine oxidase was purified from the K-12 strain of E. coli and shown to contain copper, the first example of a copper-containing amine oxidase in gram-negative bacteria.2 Amine oxidases (hereafter this phrase will refer exclusively to the copper-containing enzymes, unless otherwise indicated) catalyze the oxidative examination of primary amines:

$$ RCH_2 NH_2 + O_2 + H_2 O \to RCHO + H_2 O_2 + NH_3 $$

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Authors and Affiliations

  1. Department of Chemistry, Amherst College, Amherst, MA, 01002, USA

    David M. Dooley, Doreen E. Brown, Alexander W. Clague, Jyllian N. Kemsley, Cynthia D. McCahon, Michele A. McGuirl & Petra N. Turowski

  2. Molecular Biology Division, Veterans Administration Medical Center, San Fransisco, CA, 94121, USA

    W. S. McIntire

  3. School of Chemical Sciences, University of East Anglia, Norwich, NR4 7TJ, UK

    Jaqui A. Farrar & Andrew J. Thomson

Authors
  1. David M. Dooley
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  2. Doreen E. Brown
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  3. Alexander W. Clague
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  4. Jyllian N. Kemsley
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  5. Cynthia D. McCahon
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  6. Michele A. McGuirl
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  7. Petra N. Turowski
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  8. W. S. McIntire
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  9. Jaqui A. Farrar
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  10. Andrew J. Thomson
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Editor information

Editors and Affiliations

  1. The Johns Hopkins University, USA

    Kenneth D. Karlin  & Zoltán Tyeklár  & 

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© 1993 Chapman & Hall, Inc.

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Dooley, D.M. et al. (1993). Structure and Reactivity of Copper-Containing Amine Oxidases. In: Karlin, K.D., Tyeklár, Z. (eds) Bioinorganic Chemistry of Copper. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6875-5_37

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  • DOI: https://doi.org/10.1007/978-94-011-6875-5_37

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6877-9

  • Online ISBN: 978-94-011-6875-5

  • eBook Packages: Springer Book Archive

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