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Male fertility

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Prostaglandins and their Inhibitors in Clinical Obstetrics and Gynaecology

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Abstract

The existence of a substance or a group of substances with smooth muscle stimulating and vasodepressive properties in human semen, prostate and seminal vesicles was first described by von Euler1,2 and Goldblatt3 more than 50 years ago. The active principle was named prostaglandin (PG) by von Euler2. It was soon realized that semen was the richest natural source of prostaglandins, and seminal extracts were used for many of the early experiments that attempted to ascertain the properties of prostaglandins. Although a long time has elapsed since the discovery of these compounds, the physiological function(s) of PGs in human semen is still far from clear. The aim of this chapter is to describe their possible roles in relation to fertility.

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References

  1. von Euler, U.S. (1935). The specific blood pressure lowering substance in human prostate and seminal vesicles secretions. Klin. Wochenschr., 14, 1182–3.

    Article  Google Scholar 

  2. von Euler, U.S. (1936). On the specific vasodilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin). J. Physiol., 881, 213–34.

    Google Scholar 

  3. Goldblatt, M.W. (1933). A depressor substance in seminal fluid. J. Soc. Chem. Ind., 52, 1056–7.

    Google Scholar 

  4. Samuelsson, B. (1963). Isolation and identification of prostaglandins from human seminal fluid. J. Biol. Chem., 238, 3229–34.

    PubMed  CAS  Google Scholar 

  5. Taylor, P. L. (1979). The 8-iso prostaglandins: evidence for eight compounds in human semen. Prostaglandins, 17, 259–67.

    Article  PubMed  CAS  Google Scholar 

  6. Taylor, P.L. and Kelly, R. W. (1974). 19-hydroxylated E prostaglandins as the major prostaglandins in human semen. Nature (London), 250, 665–7.

    Article  CAS  Google Scholar 

  7. Taylor, P.L. and Kelly, R.W. (1975). The occurrence of 19-hydroxy-F prostaglandins in human semen. FEBS Lett., 57, 22–5.

    Article  PubMed  CAS  Google Scholar 

  8. Cooper, J. and Kelly, R. W. (1975). The measurement of E and 19-hydroxy E prostaglandins in human seminal fluid. Prostaglandins, 10, 507–14.

    PubMed  CAS  Google Scholar 

  9. Middleditch, B.S. (1975). PGA: fact or artifact? Prostaglandins, 9, 409–11.

    Article  CAS  Google Scholar 

  10. Gerozissis, K. and Dray, F. (1981). Radioimmunoassay of prostaglandins in the semen of fertile men. J. Reprod. Fertil., 61, 487–90.

    Article  PubMed  CAS  Google Scholar 

  11. Bygdeman, M. and Holmberg, O. (1966). Isolation and identification of prostaglandins from ram seminal plasma. Acta Chem. Scand., 20, 2308–10.

    Article  PubMed  CAS  Google Scholar 

  12. Kelly, R.W., Taylor, P.L., Hearn, J.P., Short, R.V., Martin, D.E. and Marston, J. H. (1976). 19-hydroxy prostaglandin E as a major component of the semen of primates. Nature (London), 260, 544–5.

    Article  CAS  Google Scholar 

  13. Svanborg, K., Bygdeman, M., Eneroth, P. and Bendvold, E. (1982). Quantification of prostaglandins in human seminal fluid. Prostaglandins, 24, 363–75.

    Article  PubMed  CAS  Google Scholar 

  14. Templeton, A.A., Cooper, J. and Kelly, R.W. (1978). Prostaglandin concentrations in the semen of fertile men. J. Reprod. Fertil., 52, 147–50.

    Article  PubMed  CAS  Google Scholar 

  15. Tussel, J.M. and Gelpi, E. (1980). Prostaglandins E and F, and 19-hydroxylated E and F (series I and II) in semen of fertile men. Gas and liquid Chromatographic separation with selected ion detection. J. Chromatogr., 181, 295–310.

    Article  Google Scholar 

  16. Gerozissis, K. and Dray, F. (1981). Radioimmunoassay of prostaglandins in the semen of fertile men. J. Reprod. Fertil., 61, 487–90.

    Article  PubMed  CAS  Google Scholar 

  17. Bygdeman, M. and Samuelsson, B. (1966). Analyses of prostaglandins in human semen. Prostaglandins and related factors. Clin. Chem. Acta, 13, 465–74.

    Article  CAS  Google Scholar 

  18. Bendvold, E., Svanborg, K., Eneroth, P., Gottlieb, C. and Bygdeman, M. (1984). The natural variations in prostaglandin concentration in human seminal fluid and its relation to sperm quality. Fertil. Steril., 41, 743–7.

    PubMed  CAS  Google Scholar 

  19. Carpenter, M.P., Robinson, R. D. and Thuy, L.P. (1978). Prostaglandin metabolism in human semen. FEBS Lett., 57, 22–5.

    Google Scholar 

  20. Conte, D., Laguzzi, G., Boniforti, L., Cantafora, A., DiSilverio, F., Latino, C, Lalloni, G., Mesolella, V. and Isidori, A. (1980). Prostaglandin content and metabolic activity of the human prostate. In Crastes de Paulet, A., Thaler-Dao, H. and Dray, F. (eds.) Prostaglandin and Reproductive Physiology. pp. 89–96. (Paris: INSERM).

    Google Scholar 

  21. Hamberg, M. (1976). Biosynthesis of prostaglandin E by human seminal vesicles. Lipids, 11, 249–50.

    Article  PubMed  CAS  Google Scholar 

  22. Eliasson, R. (1959). Studies on prostaglandins. Acta Physiol. Scand., Suppl. 158, 1–73.

    Google Scholar 

  23. Gerozissis, K., Jouannet, P., Soufir, J. C. and Dray, F. (1982). Origin of prostaglandins in human semen. J. Reprod. Fertil., 65, 401–6.

    Article  PubMed  CAS  Google Scholar 

  24. Bendvold, E., Svanborg, K., Bygdeman, M. and Norén, S. (1985). On the origin of prostaglandins in human seminal fluid. Int. J. Androl., 8, 37–43.

    Article  PubMed  CAS  Google Scholar 

  25. Sturde, H. C. (1971). Behaviour of sperm prostaglandins under therapy with androgen. Arzneim. Forsch., 21, 1302–7.

    CAS  Google Scholar 

  26. Skakkebaeck, N.E., Kelly, R.W. and Cocker, C.S. (1976) Prostaglandin concentrations in the semen of hypogonadal men during treatment with testosterone. J. Reprod. Fertil., 47, 119–21.

    Article  Google Scholar 

  27. Horton, E. W., Jones, R. L. and Marr, C. G. (1973). Effects of aspirin on prostaglandin and fructose levels in human semen. J. Reprod. Fertil., 33, 385–93.

    Article  PubMed  CAS  Google Scholar 

  28. Bendvold, E., Gottlieb, C, Svanborg, K., Bygdeman, M., Eneroth, P. and Cai, Q.H. (1985). The effect of naproxen on the concentration of prostaglandin in human seminal fluid. Fertil. Steril., 43, 922–6.

    PubMed  CAS  Google Scholar 

  29. Barkay, J., Harpaz-Lerpel, S., Ben-Ezra, S., Gordon, S. and Zuckerman, H. (1984). The prostaglandin inhibitor effect of antiinflammatory drugs in the therapy of male infertility. Fertil. Steril., 42, 406–11.

    PubMed  CAS  Google Scholar 

  30. Asplund, J. A. (1947). A quantitative determination of the content of contractive substances in human sperm and their significance for the motility and vitality of the spermatozoa. Acta Physiol. Scand., 13, 103–8.

    Article  PubMed  CAS  Google Scholar 

  31. Hawkins, O.F. and Labrum, A. H. (1981). Semen prostaglandin levels in 50 patients attending a fertility clinic. Acta Physiol. Scand., 13, 1–10.

    Google Scholar 

  32. Brummer, H. C. and Gillespie, A. (1972). Seminal prostaglandins and fertility. Clin. Endocrinol., 1, 363–8.

    Article  CAS  Google Scholar 

  33. Bygdeman, M., Fredericsson, B., Svanborg, K. and Samuelsson, B. (1970). The relation between fertility and prostaglandin content of seminal fluid in man. Fertil. Steril., 26, 622–9.

    Google Scholar 

  34. Collier, J. C, Flower, R. L. and Stanton, S.L. (1975). Seminal prostaglandins in infertile men. Fertil. Steril., 26, 868–71.

    PubMed  CAS  Google Scholar 

  35. Dimov, V. and Georgiev, G. (1977). Ram semen prostaglandin concentration and its effect on fertility. J. Anim. Sci., 44, 1050–4.

    PubMed  CAS  Google Scholar 

  36. Kelly, R.W., Cooper, I. and Templeton, A.A. (1979). Reduced prosta-glandin levels in the semen of men with very high sperm concentrations. J. Reprod. Fertil., 56, 195–9.

    Article  PubMed  CAS  Google Scholar 

  37. Cosentino, M.J., Emilson, L.B.V. and Cockett, A.T. K. (1984). Prosta-glandins in semen and their relation to male fertility: a study of 145 men. Fertil., Steril., 41, 88–94.

    CAS  Google Scholar 

  38. Cohen, M.S., Colin, M.J., Golimbu, M. and Hotchkiss, R. S. (1977). The effects of prostaglandins on sperm motility. Fertil., Steril., 28, 78–85.

    CAS  Google Scholar 

  39. Hedquist, P. and von Euler, U.A. (1972). Prostaglandin induced neurotransmission failure in the field stimulated vas deferens. Neuropharmacology, 11, 177–87.

    Article  Google Scholar 

  40. Spilman, H. C, Finn, A. E. and Norland, J.F. (1973). Effect of prostaglandins on sperm transport and fertilization in the rabbit. Prostaglandins, 4, 57–64.

    Article  PubMed  CAS  Google Scholar 

  41. Martin, J. N., Jr., Bygdeman, M. and Eneroth, P. (1978). The influence of locally administered prostaglandin E2 and F2α on uterine motility in the intact nonpregnant human uterus. Acta Obstet. Gynecol. Scand., 57, 141–7.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. M. Bygdeman
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Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Karolinska Hospital, S-104, 01 Stockholm, Sweden

    Marc Bygdeman MD

  2. Chapel Hill Fertility Services, 109 Conner Drive, Suite 2104, Chapel Hill, NC, 27514, USA

    Gary S. Berger MD, MSPH

  3. Department of Obstetrics and Gynecology, Northwestern University Medical School, 333 E. Superior Street, Chicago, IL, 60611, USA

    Louis G. Keith MD

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© 1986 MTP Press Limited

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Bygdeman, M. (1986). Male fertility. In: Bygdeman, M., Berger, G.S., Keith, L.G. (eds) Prostaglandins and their Inhibitors in Clinical Obstetrics and Gynaecology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6734-5_8

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  • DOI: https://doi.org/10.1007/978-94-011-6734-5_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6736-9

  • Online ISBN: 978-94-011-6734-5

  • eBook Packages: Springer Book Archive

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