Abstract
It seems well established that many teratogenic agents induce malformations as a result of their cytotoxic properties (reviewed by Scott)1. Abnormal loss of cells due to necrosis can easily be envisaged as a hindrance to normal development. Interestingly, it also appears that abnorrhal development may result when cells which normally die during development are prevented from doing so at the proper time.
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References
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Scott, W.J. (1979). Physiological cell death in normal and abnormal rodent limb development. In: Persaud, T.V.N. (eds) Abnormal Embryogenesis. Advances in the Study of Birth Defects, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6654-6_8
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DOI: https://doi.org/10.1007/978-94-011-6654-6_8
Publisher Name: Springer, Dordrecht
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