Abstract
In 1956, Fox and Goss1 suggested that the administration of teratogens such as trypan blue to developing mammalian embryos might afford a new method of experimental attack on the problems of normal morphogenesis of the heart. Sadly, however, Van Mierop and Gessner2 16 years later concluded that it had not so far been possible either by drug or mechanical interference to induce specific anomalies reproducibly in a high enough percentage of offspring to render such studies either practical or reliable. On a more positive note, they did feel that studies such as those of Patterson3 and Siller4 who have examined dogs and chickens with genetic disposition to certain cardiac defects had gone some way towards the goal of understanding the various aetiologies and mechanisms underlying these congenital abnormalities.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fox, M. H. and Goss, C. M. (1956). Experimental production of a syndrome of congenital cardiovascular defects in rats. Anat. Rec, 124, 189
Van Mierop, L. H. S. and Gessner, I. H. (1972). Pathogenetic mechanisms in congenital cardiovascular malformations. In: W. F. Friedman, M. Lesch and E. H. Sonnenblick (eds.). Neonatal Heart Disease, pp. 1–20. (New York and London: Grune and Stratton)
Patterson, D. F. (1968). Epidemiologic and genetic studies of congenital heart disease in the dog. Circ. Res., 23, 171
Siller, W. G. (1958). Aortic dextroposition complexes in the fowl. A study in comparative pathology. J. Pathol. Bacteriol, 94,155
Pexieder, T. (1975). Cell death in the morphogenesis and teratogenesis of the heart. Adv. A nat. Embryol. Cell Biol., 51,3
Ruch, J. V., Zahnd, M., Robez-Kremer, G., Rumpler, O. and Gerlinger, P. (1965). Action tératogène plusieurs substances sur la morphogenèse cardiaque de l’embryon de poulet. Arch. Biol., 76, 25
Khera, K. S. and Heggtveit, M. A. (1974). Fetal cardiovascular defects induced by thalidomide in the cat. Teratology, 9, 24
Kalter, H. and Warkany, J. (1961). Experimental production of congenital malformations in strains of inbred mice by maternal treatment with hypervitaminosis A. Am. J. Pathol., 38,1
Nolan, G. A. (1969). Variations in teratogenic response to hypervitaminosis A in three strains of the albino rat. Food Cosmet. Toxicol., 1, 209
Robens, J. F. (1970). Teratogenic effects of hypervitaminosis A in the hamster and the guinea pig. Toxicol Appl. Pharmacol., 16, 88
Fantel, A. G., Shepard, T. H., Newell-Morris, L. L. and Moffett, B. C. (1977). Teratogenic effects of retinoic acid in pigtail monkeys. Teratology, 15, 65
Shenefelt, R. E. (1972). Morphogenesis of malformations in hamsters caused by retinoic acid: relation to dose and stage at treatment. Teratology, 5,103
Taylor, I. M., Wiley, M. J. and Agur, A. (1979). Retinoic acid-induced bulboventricular malformations in the hamster. (In preparation)
Lev. M., Bharati, S., Meng, C. C. L., Liberthson, R. R., Paul, M. H. and Idriss, F. (1972). A concept of double outlet right ventricle. J. Thoracic Cardiovasc. Surg., 64, 271
Goor, D. A. and Edwards, J. E. (1973). The spectrum of transposition of the great arteries: With specific reference to developmental anatomy of the conus. Circulation, 48,406
Anderson, R. H., Arnold, R., Wilkinson, A., Becker, A. E. and Lubkiewicz, K. (1974). Morphogenesis of bulboventricular malformations. II. Observations on malformed hearts. Br. Heart J., 36, 948
Van Mierop, L. H. S. and Wiglesworth, F. W. (1963). Pathogenesis of transposition complexes. II. Anomalies due to faulty transfer of the posterior great artery. III. True transposition of the great vessels. Am. J. Cardiol., 12, 226
Ong, D. E., Page, D. L. and Chytil, F. (1975). Retinoic acid binding protein: occurrence in human tumors. Science, 190, 60
Ong, D. E. and Chytil, F. (1976). Changes in levels of cellular retinol-and retinoic-acid binding proteins of liver and lung during perinatal development of rat. Proc. Natl. Acad. Sci. (USA), 73, 3976
Hurley, L. S. (1977). Nutritional deficiencies and excesses. In: J. G. Wilson and F. Clarke Fraser (eds.) Handbook of Teratology, Vol. 1, pp. 261–308 (New York and London: Plenum Press)
Morriss, G. M. (1973). The ultrastructural effects of excess maternal vitamin A on the primitive streak stage rat embryo. J. Emhryol. Exp. Morphol., 30, 219
Daniel, M. R., Dingle, J. T., Glauert, A. M. and Lucy, J. A. (1966). The action of excess vitamin A alcohol on the fine structure of rat dermal fibroblasts. J. Cell Biol., 30,465
Schweichel, J. U. and Merker, H. J. (1973). The morphology of various types of cell death in prenatal tissues. Teratology, 7, 253
Wenzel, D. G. and Acosta, D. (1973). Permeability of lysosomes and mitochondria in cultured rat heart muscle and endotheloid cells as affected by vitamin A, chlorpromazine, amphotericin B and Clofibrate. Res. Comm. Chem. Pathol. Pharmacol., 6, 689
Kwasigroch, T. E. and Kochhar, D. M. (1975). Locomotory behaviour of limb bud cells: effect of excess vitamin A in vivo and in vitro. Exp. Cell Res., 95, 269
Christophers, E. and Wolff, H. H. (1975). Differential formation of desmosomes and hemidesmosomes in epidermal cell cultures treated with retinoic acid. Nature, 256, 209
Elias, P. M. and Friend, D. S. (1976). Vitamin A induced mucous metaplasia. An in-vitro system for modulating tight and gap junction differentiation. J. Cell Biol., 68, 173
Markwald, R. R., Fitzharris, T. P. and Adams Smith, W. N. (1975). Structural analysis of endocardial cytodifferentiation. Dev. Biol., 42, 160
Solursh, M. and Meier, S. (1973). The selective inhibition of mucopolysaccharide synthesis by vitamin A treatment of cultured chick embryo chondrocytes. Calcif. Tissue Res., 13, 131
Schimmelpfennig, K., Baumann, I. and Kaufmann, C. (1972). Studies on glycosamino-glycans (GAG) in mammalian embryonic tissue. II. Influence of vitamin A and Na-salicyate on embryonic GAG. Naunyn-Schmiedeberg’s Arch. Pharmacol., 272, 65
DeLuca, L. and Wolf, G. (1970). Vitamin A and mucus secretion. A brief review of the effect of vitamin A on the biosynthesis of glycoproteins. Int. Z. Vitamin Forsch., 40, 284
Fraser, B. A. (1977). The relationship of aberrant vasculogenesis to retinoic acid induced dysmelia in the hamster fetus. Presented at the 5th International Conference on Birth Defects, August 21–27, Montreal
Editor information
Rights and permissions
Copyright information
© 1979 MTP Press Limited
About this chapter
Cite this chapter
Taylor, I.M. (1979). The effect of retinoic acid on the developing hamster heart — an ultrastructural and morphological study. In: Persaud, T.V.N. (eds) Abnormal Embryogenesis. Advances in the Study of Birth Defects, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6654-6_7
Download citation
DOI: https://doi.org/10.1007/978-94-011-6654-6_7
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-6656-0
Online ISBN: 978-94-011-6654-6
eBook Packages: Springer Book Archive