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Effects of steroid sex hormones on the development of early mouse embryos in vitro and in vivo

  • Chapter
Teratological Testing

Part of the book series: Advances in the Study of Birth Defects ((ASBD,volume 2))

Abstract

The teratogenicity of steroid sex hormones is a matter of controversy. Several recent clinical and experimental studies suggest that the hormones can induce congenital abnormalities in sex organs of male1 and female2–5 offspring. Other studies question their involvement in the production of neural tube defects6–8, the transposition of great vessels9–13, VACTERL and DiGeorge syndromes10,14,15 and limb malformations16–18. In addition, epidemiological studies fail to agree on the subject19–27, but this may be due to lack of uniformity in route, frequency and dose of administration of the hormones, as well as incomplete information about the stage of pregnancy during treatment.

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Authors
  1. H.-G. Eibs
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  2. H. Spielmann
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  3. Margret Hägele
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  4. J. Klose
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Editors and Affiliations

  1. Department of Anatomy Faculties of Medicine and Dentistry, University of Manitoba, 730 William Avenue, R3E 0W3, Winnipeg, Manitoba, Canada

    T. V. N. Persaud

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Eibs, HG., Spielmann, H., Hägele, M., Klose, J. (1979). Effects of steroid sex hormones on the development of early mouse embryos in vitro and in vivo . In: Persaud, T.V.N. (eds) Teratological Testing. Advances in the Study of Birth Defects, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6651-5_6

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  • DOI: https://doi.org/10.1007/978-94-011-6651-5_6

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