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Usefulness of Golden Syrian hamster in experimental teratology with particular reference to the induction of orofacial malformations

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Teratological Testing

Part of the book series: Advances in the Study of Birth Defects ((ASBD,volume 2))

Abstract

There is something metaphysical about malformations in general, and orofacial malformations in particular. Some of them are easy to recognize with the naked eye; others require physiological, biochemical and/or microscopic analysis. Nevertheless, the extent and severity of these malformations can be immediately life-threatening or detrimental to later development.

‘I shouldn’t know you again if we did meet’, Humpty Dumpty replied in a discontented tone, giving her one of his fingers to share. ‘You’re so exactly like other people’. ‘The face is what one goes by, generally’, Alice remarked in a thoughtful tone. ‘That’s just what I complain of’, said Humpty Dumpty. ‘Your face is the same as everybody has - the two eyes, so -’ (marking their places in the air with his thumb) ‘nose in the middle, mouth under. It is always the same. Now if you had two eyes on the same side of the nose, for instance - or the mouth at the top - that would be some help. ‘It wouldn’t look nice’, Alice objected. But Humpty Dumpty only shut his eyes, and said, ‘Wait till you’ve tried’. Through the Looking-Glass, Lewis Carroll

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References

  1. Heboid, G. (1973). General and special toxicological testing of drugs. Recommendations of various countries. Pharm. Ind., 35, 205

    Google Scholar 

  2. Tuchmann-Duplessis, H. (1972). Teratogenic drug screening. Present procedures and requirements. Teratology, 5, 271

    Article  PubMed  CAS  Google Scholar 

  3. Ferngren, H. and Forsberg, U. (1971). Evaluation in animals of teratogenic effects of drugs submitted to the Swedish Drug Control 1963–1968. Proc. Eur. Soc. Study Drug Toxic., 12, 347

    CAS  Google Scholar 

  4. Dunlop Committee for the Safety of New Drugs. Report. (1968)

    Google Scholar 

  5. Food and Drug Administration. (1966). Guidelines for reproduction studies for safety evaluation of drugs for human use

    Google Scholar 

  6. World Health Organization Scientific Group. (1967). Principles for testing of drugs for teratogenicity. WHO Tech. Rep. Ser., 364, 1

    Google Scholar 

  7. Health and Welfare Canada. (1973). The testing of chemicals for carcinogenicity, mutagenicity, teratogenicity

    Google Scholar 

  8. Orsini, M. W. (1961). The external vaginal phenomena characterizing the stages of the estrous cycle, pregnancy, pseudopregnancy, lactation and the anestrous hamster, Mesocricetus auratus Waterhouse. Proc. A nimal Care Panel, 11, 193

    Google Scholar 

  9. Graves, A. P. (1945). Development of the golden hamster, Cricetus auratus Waterhouse, during the first nine days. Am. J. Anat., 77, 219

    Article  Google Scholar 

  10. Boyer, C. (1968). Embryology. In: R. A. Hoffman, P. F. Robinson and H. Magalhaes (eds.). The Golden Hamster: Its Biology and Use in Medical Research, pp. 73–90. ( Ames: The Iowa State University Press )

    Google Scholar 

  11. Shenefelt, R. E. (1972). Morphogenesis of malformations in hamsters caused by retinoic acid: relation to dose and stage of treatment. Teratology, 5, 103

    Article  PubMed  CAS  Google Scholar 

  12. Homburger, F. (1976). Potential contribution of inbred Syrian hamsters to future toxicology. Adv. Modern Toxicol., 1, 35

    Google Scholar 

  13. Kilham, L. and Ferm, V. H. (1976). Exencephaly in fetal hamsters following exposure to hyperthermia. Teratology, 14, 323

    Article  PubMed  CAS  Google Scholar 

  14. Ferm, V. H. and Kilham, L. (1977). Synergistic teratogenic effects of arsenic and hyper-thermia in hamsters. Envir. Res., 14, 483

    Article  CAS  Google Scholar 

  15. Umpierre, C. C. and Dukelow, W. R. (1977). Environmental heat stress effects in the hamster. Teratology, 16, 155

    Article  PubMed  CAS  Google Scholar 

  16. Smith, A. U. (1957). The effects on foetal development of freezing pregnant hamsters (Mesocricetus auratus). J. Embryol. Exp. Morphol., 5, 311

    Google Scholar 

  17. Harvey, E. B. and Chang, M. C. (1962). Effects of radiocobalt irradiation of pregnant hamsters on the development of embryos. J. Cell. Comp. Physiol., 59, 293

    Article  PubMed  CAS  Google Scholar 

  18. Jensh, R. P. and Magalhaes, H. (1962). The effect of whole body X-irradiation on the central nervous system of golden hamster embryos. Penn. Acad. Sci., 36, 194

    Google Scholar 

  19. Ferm, V. H. (1964). Teratogenic effects of hyperbaric oxygen. Proc. Soc. Exp. Biol. Med., 116, 975

    PubMed  CAS  Google Scholar 

  20. Marin-Padilla, M. and Ferm, V. H. (1965). Somite necrosis and developmental malformations induced by vitamin A in the golden hamster. J. Embryol. Exp. Morphol., 13, 1

    PubMed  CAS  Google Scholar 

  21. Ferm, V. H. and Carpenter, S. J. (1968). Malformations induced by sodium arsenate. J. Reprod. Fertil., 17, 199

    Article  PubMed  CAS  Google Scholar 

  22. Ferm, V. H. and Carpenter, S. J. (1967). Developmental malformations resulting from the administration of lead salts. Exp. Mol. Pathol., 7, 208

    Article  PubMed  CAS  Google Scholar 

  23. Ferm, V. H. (1969). The synteratogenic effect of lead and cadmium. Experientia, 25, 56

    Article  PubMed  CAS  Google Scholar 

  24. Ferm, V. H. and Carpenter, S. J. (1968). The relationship of cadmium and zinc in experimental mammalian teratogenesis. Lab. Invest., 18, 429

    PubMed  CAS  Google Scholar 

  25. Ferm, V. H. (1971). Developmental malformations induced by cadmium. A study of timed injections during embryogenesis. Biol. Neonate, 19, 101

    Article  PubMed  CAS  Google Scholar 

  26. Gale, T. F. and Ferm, V. H. (1973). Skeletal malformations resulting from cadmium treatment in the hamster. Biol Neonate, 23, 149

    Article  PubMed  CAS  Google Scholar 

  27. Gale, T. F. and Ferm, V. H. (1973). Embryopathic effects of mercuric salts. Life Sci., 10, 1341

    Article  Google Scholar 

  28. Gale, T. F. (1973). The interaction of mercury with cadmium and zinc in mammalian embryonic development. Emir. Res., 6, 95

    Article  CAS  Google Scholar 

  29. Gale, T. F. (1974). Embryopathic effects of different routes of administration of mercuric acetate in the hamster. Emir. Res., 8, 207

    Article  CAS  Google Scholar 

  30. Ferm, V. H. and Carpenter, S. J. (1970). Teratogenic and embryopathic effects of indium, gallium and germanium. Toxicol. Appl. Pharmacol., 16, 166

    Article  PubMed  CAS  Google Scholar 

  31. Gale, T. F. (1975). The embryotoxicity of ytterbium chloride in golden hamsters. Teratology, 11, 289

    Article  PubMed  CAS  Google Scholar 

  32. Wiley, M. J. and Joneja, M. G. (1976). The teratogenic effects of 3-amino propionitrile in hamsters. Teratology, 14, 43

    Article  PubMed  CAS  Google Scholar 

  33. Wiley, M. J. and Joneja, M. G. (1978). Neural tube lesions in the offspring of hamsters given single oral doses of lathyrogens early in gestation. Acta Anat., 100, 347

    Article  PubMed  CAS  Google Scholar 

  34. Geber, W. F. and Schramm, L. C. (1969). Teratogenicity of marihuana extract as in-fluenced by plant origin and seasonal variation. Arch. Int. Pharmacol. Therap., 111, 224

    Google Scholar 

  35. Geber, W. F. and Schramm, L. C. (1969). Effects of marihuana extract on fetal hamsters and rabbits. Toxicol. Appl. Pharmacol., 14, 276

    Article  PubMed  CAS  Google Scholar 

  36. Geber, W. F. and Schramm, L. C. (1969). Comparative teratogenicity of morphine, heroin and methadone in the hamster. Pharmacologist, 11, 248

    Google Scholar 

  37. Geber, W. F. and Schramm, L. C. (1975). Congenital malformations of the central nervous system produced by narcotic analgesics in the hamster. Am. J. Obstet. Gynecol., 123, 705

    PubMed  CAS  Google Scholar 

  38. Geber, W. F. (1967). Congenital malformations induced by mescaline, lysergic acid diethylamide, and bromolysergic acid in the hamster. Science, 158, 265

    Article  PubMed  CAS  Google Scholar 

  39. Shah, R. M. (1977). Induction of cleft palate in hamster fetus following prenatal treatment with ACTH. Toxicol. Appl Pharmacol, 42, 229

    Article  PubMed  CAS  Google Scholar 

  40. Shah, R. M. and Chaudhry, A. P. (1973). Hydrocortisone induced cleft palate in hamsters. Teratology, 7, 191

    Article  PubMed  CAS  Google Scholar 

  41. Chaudhry, A. P. and Shah, R. M. (1973). Estimation of hydrocortisone dose and optimal gestation period for cleft palate induction in golden hamster. Teratology, 8, 139

    Article  PubMed  CAS  Google Scholar 

  42. Shah, R. M. and Travill, A. A. (1976). The teratogenic effects of hydrocortisone on palatal development in hamster. J. Embryol. Exp. Morphol, 35, 213

    PubMed  CAS  Google Scholar 

  43. Shah, R. M. and Kilistoff, A. (1976). Cleft palate induction in hamster fetuses by glucocorticoid hormones and their synthetic analogues. J. Embryol Exp. Morphol, 36, 101

    PubMed  CAS  Google Scholar 

  44. Ferm, V. H. (1963). Congenital malformations in hamster embryos after treatment with vinblastine and vincristine. Science, 141, 426

    Article  PubMed  CAS  Google Scholar 

  45. Ferm, V. H. (1965). Teratogenic activity of hydroxyurea. Lancet, 1, 1338

    Article  Google Scholar 

  46. Ferm, V. H. (1966). Severe developmental malformations. Malformations induced by urethane and hydroxyurea in the hamster. Arch. Pathol, 81, 174

    Google Scholar 

  47. Fischer, D. S. and Jonas, A. M. (1965). Cerebellar hypoplasia resulting from cytosine arabinoside treatment in the neonatal hamster. Clin. Res., 13, 540

    Google Scholar 

  48. Sullivan, G. E. and Takacs, E. (1971). Comparative teratogenicity of pyrimethamine in rats and hamsters. Teratology, 4, 205

    Article  CAS  Google Scholar 

  49. Elis, J. and DiPaolo, J. A. (1970). The alteration of actinomycin D teratogenicity by hormones and nucleic acid. Teratology, 3, 33

    Article  PubMed  CAS  Google Scholar 

  50. Degenhardt, K. H., Yamamura, H., Franz, J. and Kleinebrecht, J. (1971). Dose response to 5-fluoro-2-deoxyuridine in organogenesis of the golden hamster. Cong. Anom., 11, 41

    Google Scholar 

  51. Roux, C. and Horvath, C. (1970). Effet teratogene de I’hadacidine chez la souris et le hamster. C. R. Soc. Biol, 164, 2171

    CAS  Google Scholar 

  52. Shah, R. M. (1977). Effects of prenatal administration of hadacidin, a cancer chemo- therapeutic agent, on the development of hamster i fetuses. J. Embryol Exp. Morphol, 39, 203

    PubMed  CAS  Google Scholar 

  53. Ruffolo, P. R. and Ferm, V. H. (1965). The embryocidal and teratogenic effects of 5- bromodeoxyuridine in the pregnant hamster. Lab. Invest., 14, 1547

    PubMed  CAS  Google Scholar 

  54. Shah, R. M. and MacKay, R. A. (1978). Teratological evaluation of 5-fluorouraeil and 5-bromo-2-deoxyuridine on hamster fetuses. J. Embryol. Exp. Morphol., 43, 47

    PubMed  CAS  Google Scholar 

  55. Shah, R. M. and Burdett, D. N. (1979). Developmental abnormalities induced by 6- mercaptopurine in the hamster. Canad. J. Physiol Pharmacol., 57, 53

    Article  CAS  Google Scholar 

  56. Turbow, M. M., Clark, W. H. and DiPaolo, J. A. (1971). Embryonic abnormalities in hamsters following intra-uterine injection of 6-aminonicotinamide. Teratology, 4, 427

    Article  PubMed  CAS  Google Scholar 

  57. Ferm, V. H. (1963). Colchicine teratogenesis in hamster embryos. Proc. Soc. Exp. Biol. Med., 112, 775

    PubMed  CAS  Google Scholar 

  58. Robens, J. F. (1969). Teratological studies of carbaryl, diazinon, norea, disulfiram and thiram in small laboratory animals. Toxicol. Appl. Pharmacol., 15, 152

    Article  PubMed  CAS  Google Scholar 

  59. Ottolenghi, A. D., Haseman, J. K. and Suggs, F. (1974). Teratogenic effects of aldrin, dieldrin and endrin in hamsters and mice. Teratology, 9, 11

    Article  PubMed  CAS  Google Scholar 

  60. Murphy, J. C., Collins, T. F. X., Black, T. N. and Osterberg, R. E. (1975). Evaluation of the teratogenic potential of a spray adhesive in hamsters. Teratology, 11, 243

    Article  PubMed  CAS  Google Scholar 

  61. Homburger, F., Chaube, S., Eppenberger, M., Bogdonoff, P. D. and Nixon, C. W. (1965). Susceptibility of certain inbred strains of hamsters to teratogenic effects of thalidomide. Toxicol. Appl. Pharmacol., 7, 686

    Article  PubMed  CAS  Google Scholar 

  62. Layton, W. M. (1971). Teratogenic action of acetazolamide in golden hamsters. Teratology, 4, 95

    Article  PubMed  CAS  Google Scholar 

  63. Storch, T. G. and Layton, W. M. (1973). Teratogenic effects of intra-uterine injection of acetazolamide and amiloride in hamsters. Teratology, 7, 209

    Article  PubMed  CAS  Google Scholar 

  64. Lapointe, R. and Harvey, E. B. (1964). Salicylamide induced anomalies in hamster embryos. J. Exp. Zool., 156, 197

    Article  PubMed  CAS  Google Scholar 

  65. Geber, W. F. (1969). Angiotens in teratogenicity in the fetal hamster. Life Sci., 8, 525

    Article  PubMed  CAS  Google Scholar 

  66. Ferm, V. H. (1958). Teratogenic effects of trypan blue on hamster embryos. J. Embryol. Exp. Morphol., 6, 284

    PubMed  CAS  Google Scholar 

  67. Geber, W. F. (1969). Comparative teratogenicity of isoproterenol and trypan blue in the fetal hamster. Proc. Soc. Exp. Biol. Med., 130, 1168

    PubMed  CAS  Google Scholar 

  68. Shah, R. M., Donaldson, D. and Burdett, D. (1979). Teratological evaluation of diazepam in hamster. Canad. J. Physiol. Pharmacol. (In press)

    Google Scholar 

  69. Mizutani, M. and Ihara, T. (1973). Teratogenicity of 5-hydroxy-p-oxo-L-norvaline. 1. Studies in mice, rats, hamsters and rabbits. Teratology, 8, 99

    Google Scholar 

  70. Hood, R. D., Naughton, M. J. and Hayes, A. W. (1976). Prenatal effects of ochratoxin A in hamsters. Teratology, 13, 11

    Article  PubMed  CAS  Google Scholar 

  71. Juszkiewicz, T., Rakalska, Z. and Dzierzawski, A. (1971). Effect embryopathique du 3, 3-dichloro-5, 5-dinitro 0, 0-biphenol (Bayer 9015) chez le hamster, dore. J. Eur. Toxic., 4, 525

    CAS  Google Scholar 

  72. Ferm, V. H. (1966). Congenital malformations induced by dimethyl sulphoxide in the golden hamster. J. Embryol. Exp. Morphol., 16, 49

    PubMed  CAS  Google Scholar 

  73. Kilham, L. and Margolis, G. (1969). Hydrocephalus in hamsters, ferrets, rats and mice following inocculation with reovirus type I. Lab. Invest., 21, 183

    PubMed  CAS  Google Scholar 

  74. Kilham, L. and Margolis, G. (1974). Congenital infections due to reovirus type 3 in hamsters. Teratology, 9, 51

    Article  PubMed  CAS  Google Scholar 

  75. Ferm, V. H. and Kilham, L. (1964). Congenital anomalies induced in hamster embryos with H-l virus. Science, 145, 510

    Article  PubMed  CAS  Google Scholar 

  76. Baxter, H. and Fraser, F. C. (1949). Production of congenital defects of offspring of female mice treated with cortisone. McGill Med. J., 19, 245

    Google Scholar 

  77. Johnston, M. C., Bhakdinaronk, A. and Reid, Y. C. (1973). An expanded role of the neural crest in oral and pharyngeal development. In: J. F. Bosma (ed.). Oral Sensation and Perception: Development in the Fetus and Infant, pp. 37–52. ( Washington: U.S. Government Printing Office )

    Google Scholar 

  78. Nishimura, H. and Shiota, K. (1977). Summary of comparative embryology and tera-tology. In: J. G. Wilson and F. C. Fraser (eds.). Handbook of Teratology, Vol. 3, pp. 119–154. ( New York: Plenum Press )

    Google Scholar 

  79. Brent, R. L. (1978). Editor’s note. Teratology, 17, 183

    Article  PubMed  CAS  Google Scholar 

  80. Guilbeau, J. A. (1953). Effects of cortisone on the fetus. Am. J. Obstet. Gynecol., 65, 227

    PubMed  Google Scholar 

  81. Wells, C. N. (1953). Treatment of hyperemesis gravidarum with cortisone. I. Fetal results. Am. J. Obstet. Gynecol, 66, 598

    PubMed  CAS  Google Scholar 

  82. Doig, R. K. and Coltman, O. M. (1956). Cleft palate following cortisone therapy in early pregnancy. Lancet, 11, 730

    Article  Google Scholar 

  83. Harris, J. W. and Ross, I. P. (1956). Cortisone therapy in early pregnancy - relation to cleft palate. Lancet, 1, 1045

    Article  Google Scholar 

  84. Reilly, W. A. (1958). Hormone therapy during pregnancy: effects on the fetus and newborn. Qu. Rev. Pediatr., 13, 198

    CAS  Google Scholar 

  85. Bongiovanni, A. M. and McFadden, A. J. (1960). Steroid during pregnancy and possible fetal consequences. Fert. Steril., 11, 181

    CAS  Google Scholar 

  86. Volpato, S. and Scarpa, P. (1961). Bilateral complete agenesis of the radius in a newborn (eventual teratogenic activity of cortisone). Acta Pediatr. Scand., 14, 154

    Google Scholar 

  87. Popert, A. J. (1962). Pregnancy and adrenocortical hormones. Some aspects of their action in rheumatic disease. Br. Med. J., 1, 967

    Article  PubMed  CAS  Google Scholar 

  88. Noda, T., Ueda, K. and Satoyama, M. (1963). A case of malformed infant bora to a mother treated with adrenocorticoids during pregnancy. Sanfujinka No Shimpo, 15, 189

    Google Scholar 

  89. Malpas, P. (1965). Foetal malformation and cortisone therapy. Br. Med. J., 1, 795

    Article  PubMed  CAS  Google Scholar 

  90. Warrell, D. W. and Taylor, R. (1968). Outcome for the fetus of mothers receiving pred-nisolone during pregnancy. Lancet, 1, 117

    Article  PubMed  CAS  Google Scholar 

  91. Serment, H. and Ruf, H. (1968). Les dangers pour le produit de conception de medicaments administres a la femme enceinte. Bull. Fed. Soc. Gynecol. Obstet. Lang. Fr., 20, 69

    Google Scholar 

  92. Khudr, G. and Olding, L. (1973). Cyclopia. Am. J. Dis. Child., 125, 120

    PubMed  CAS  Google Scholar 

  93. Schatz, M., Patterson, R., Zeitz, S., O’Rourke, J. and Melam, H. (1975). Corticosteroid therapy for the pregnant asthmatic patient. J. Am. Med. Ass., 234, 804

    Article  Google Scholar 

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  1. R. M. Shah
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Editors and Affiliations

  1. Department of Anatomy Faculties of Medicine and Dentistry, University of Manitoba, 730 William Avenue, R3E 0W3, Winnipeg, Manitoba, Canada

    T. V. N. Persaud

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Shah, R.M. (1979). Usefulness of Golden Syrian hamster in experimental teratology with particular reference to the induction of orofacial malformations. In: Persaud, T.V.N. (eds) Teratological Testing. Advances in the Study of Birth Defects, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6651-5_2

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  • DOI: https://doi.org/10.1007/978-94-011-6651-5_2

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