Skip to main content
SpringerLink
Log in

Experimental studies on the influence of male alcoholism on testicular function, pregnancy and progeny

  • Chapter
Teratological Testing

Part of the book series: Advances in the Study of Birth Defects ((ASBD,volume 2))

  • 68 Accesses

Abstract

The problem of alcohol abuse has reached alarming proportions. Despite the increasing number of reports dealing with the medical, social and economical aspects of alcoholism, the production of alcoholic spirits continues to increase by nearly 10% annually1,2. The relationship of alcohol consumption to disease has been well documented; however, its total involvement indicates the necessity for further investigation3.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. W.H.O. (1975). Alcohol: A growing danger. W.H.O. Chronicle, 29, 102

    Google Scholar 

  2. W.H.O. (1975). Problems of non-medical drug use. W.H.O. Chronicle, 29, 97

    Google Scholar 

  3. Seixes, F. A., Williams, K. and Eggleston, S. (1975). Medical consequences of alcoholism. Ann. New York Acad. Sci., 252, 10–396

    Article  Google Scholar 

  4. Stockard, C. R. (1910). The influence of alcohol and other anaesthetics on embryonic development. Am. J. Anat., 10, 369

    Article  Google Scholar 

  5. Stockard, C. R. (1912). An experimental study of racial degeneration in mammals treated with alcohol. Arch. Int. Med., 10, 369

    Article  Google Scholar 

  6. Stockard, C. R. and Craig, D. M. (1912). An experimental study of the influence of alcoholism on the germ cells and the developing embryos of mammals. Arch. f. Entwickl., 35, 569

    Article  Google Scholar 

  7. Nice, L. B. (1912). Comparative studies on the effects of alcohol, nicotine, tobacco smoke and caffeine on white mice. I. Effects on reproduction and growth. J. Exp. Zool., 12, 133

    Article  CAS  Google Scholar 

  8. Stockard, C. R. (1913). The effect on the offspring of intoxicating the male parent and the transmission of the defects to subsequent generations. Am. Nat., 47, 641

    Article  Google Scholar 

  9. Pearl, R. (1917). The experimental modification of germ cells: The effect of parental alcoholism, and certain other drug intoxications, upon the progeny. J. Exp. Zool., 22, 241

    Article  CAS  Google Scholar 

  10. MacDowell, E. C. and Lord, E. M. (1927). Cited in Willis, R. A. ( 1962 ) The Borderland of Embryology and Pathology. (London: Butterworth )

    Google Scholar 

  11. Durham, F. M. and Woods, H. M. (1932). Alcohol and inheritance: An experimental study. Med. Res. Coun, Spec. Report Series No. 168 (London)

    Google Scholar 

  12. Sandor, S. and Elias, S. (1968). The influence of ethyl-alcohol on the development of the chick embryo. Revue Roumaine dEmbryologie et de Cytologic - Serie Embryologie, 5, 51

    Google Scholar 

  13. Sandor, S. (1968). The influence of ethyl alcohol on the developing chick embryo II. Revue Roumaine d Embryologie et de Cytologie - Serie dEmbryologie, 5, 167

    CAS  Google Scholar 

  14. Sandor, S. and Amels, D. (1971). The action of ethanol on the prenatal development of albino rats. Revue Roumaine dEmbryologie et de Cytologie - Serie dEmbryologie, 8, 37

    Google Scholar 

  15. Jones, K. L., Smith, D. W., Streissguth, A. P. and Myrianthopoulos, N. C. (1974). Outcome in offspring of chronic alcoholic women. Lancet, 1, 1076

    Article  PubMed  CAS  Google Scholar 

  16. Badr, F. and Badr, R. (1975). Induction of dominant lethal mutation in male mice by ethyl alcohol. Nature (Lond.), 253 134

    Article  CAS  Google Scholar 

  17. Tenbrinck, M. S. and Buchin, S. Y. (1975). Fetal alcohol syndrome. Report of a case. J. Am. Med. Ass., 232, 1144

    Article  CAS  Google Scholar 

  18. Tze, W. J. and Lee, M. (1975). Adverse effects of maternal alcohol consumption on pregnancy and foetal growth in rats. Nature (Lond.), 257, 479

    Article  CAS  Google Scholar 

  19. Clarren, S. K. and Smith, D. W. (1978). The fetal alcohol syndrome. N. Eng. J. Med., 298, 1063

    Article  CAS  Google Scholar 

  20. Clarren, S. K., Alvord, E. C., Sumi, M., Streissguth, A. P. and Smith, D. W. (1978). Brain malformations related to prenatal exposure to ethanol. J. Pediat., 92, 64

    Article  PubMed  CAS  Google Scholar 

  21. Lutzen, L. and Ueberberg, H. (.1973J. A study on morphological changes in the testes of old albino rats. Beitr. Path., 149, 377

    Google Scholar 

  22. Stearns, E. L., MacDonnell, J. A., Kaufman, B. J., Padua, R., Lucman, T. S., Winter, J. S. D. and Faiman, C. (1974). Declining testicular function with age. Am. J. Med., 57, 761

    Article  PubMed  CAS  Google Scholar 

  23. Siperstein, D. (1920). The effects of acute and chronic inanition upon the development and structure of the testis in the albino rat. Anat. Rec., 20, 355

    Article  Google Scholar 

  24. Mauer, S. and Mason, K. (1975). Antisterility activity of d-cr-tocopheryl hydroquinone in the vitamin E-deficient male hamster and rat. J. Nutr., 105, 491

    PubMed  CAS  Google Scholar 

  25. Bowler, K. (1972). The effect of repeated applications of heat on-spermatogenesis in the rat: a histological study. J. Reprod. Fertil, 28, 325

    Article  PubMed  CAS  Google Scholar 

  26. Hildebrand, D., Der, R., Griffin, W. and Fahim, M. (1973). Effect of lead acetate on reproduction. Am. J. Obstet. Gynecol., 115, 1058

    Google Scholar 

  27. Lee, I. and Dixon, R. (1973). Effects of cadmium on spermatogenesis studied by velocity sedimentation cell separation and serial mating. J. Pharmacol. Exp. Ther., 187, 641

    PubMed  CAS  Google Scholar 

  28. Cooper, E., Jones, A. and Jackson, H. (1974). Effects of a-chlorohydrin and related compounds on the reproductive organs and fertility of the male rat. J. Reprod. Fertil., 28, 379

    Google Scholar 

  29. Ahluwalia, R., Gambhir, K. and Sekhon, H. (1975). Distribution of labeled retinyl acetate and retinolic acid in rat and human testes. A site of retinyl acetate incorporation in rat testes. J. Nutr., 105, 467

    PubMed  CAS  Google Scholar 

  30. Cicero, T., Bell, R., Wiest, W., Allison, J., Polakoski, K. and Robins, E. (1975). Function of the male sex organs in heroin and methadone users. N. Eng. J. Med., 292, 882

    Article  CAS  Google Scholar 

  31. Kalla, N. and Bansal, M. (1975). Effect of carbon tetrachloride on gonadal physiology in male rats. Acta Anat 91, 380

    Article  PubMed  CAS  Google Scholar 

  32. Nagy, F. and Edmonds, R. (1975). Cellular proliferation and renewal in the various zones of the hamster epididymis after colchicine administration. Fértil. Steril., 26, 460

    PubMed  CAS  Google Scholar 

  33. Urry, R. and Dougherty, K. (1975). Inhibition of rat spermatogenesis and seminiferous tubule growth after short-term and long-term administration of a monoamine oxidase inhibitor. Fértil. Steril, 26, 232

    PubMed  CAS  Google Scholar 

  34. Arlit, A. H. and Wells, H. G. (1917). The effect of alcohol on the reproductive tissues. J. Exp. Med., 26, 769

    Article  CAS  Google Scholar 

  35. Van Thiel, D., Cavaler, J., Lester, R. and Goodman, M. (1975). Alcohol-induced testicular atrophy. Gastroenterology, 69, 326

    PubMed  Google Scholar 

  36. Lutwak-Mann, C. (1964). Observations on progeny of thalidomide treated male rabbits. Br. Med. J., 1, 1090

    Article  PubMed  CAS  Google Scholar 

  37. Clay, M. L. (1964). Conditions affecting voluntary alcohol consumption in rats. Qu. J. Stud. Alcohol, 25, 36

    CAS  Google Scholar 

  38. Myers, R. D. (1966). Voluntary alcohol consumption in animals: Peripheral and intra-cerebral factors. Psychosom. Med., 28, 484

    Google Scholar 

  39. Essig, C. F. and Lam, R. C. (1968). Convulsions and hallucinatory behaviour following alcohol withdrawal in the dog. Arch. Neurol., 18, 626

    Article  PubMed  CAS  Google Scholar 

  40. Deneau, G., Yanagita, T. and Seevers, M. R. (1969). Self administration of psychoactive substances by the monkey. Psychopharmacologie, 16, 30

    Article  CAS  Google Scholar 

  41. Freund, G. (1969). Alcohol withdrawal syndrome in mice. Arch. Neurol, 21, 315

    Article  PubMed  CAS  Google Scholar 

  42. Goldstein, D. B. and Pal, N. (1971). Alcohol dependence produced in mice by inhalation of ethanol: Grading the withdrawal reaction. Science, 172, 288

    Article  PubMed  CAS  Google Scholar 

  43. Ellis, F. W. and Pick, J. R. (1970). Experimentally induced ethanol dependence in Rhesus monkeys. J. Pharmacol Exp. Ther., 175, 88

    PubMed  CAS  Google Scholar 

  44. Woods, J. H., Ikomi, F. and Winger, G. D. (1971). The reinforcing property of ethanol. In: M. K. Rooch, W. M. Mclssac and P. J. Creaven (eds.). Biological Aspects of Alcohol, pp. 371–388. ( Texas: Austin University Texas Press )

    Google Scholar 

  45. Falk, J. L., Samson, H. and Winger, G. (1972). Behavioural maintenance of high concentrations of blood ethanol and physical dependence in the rat. Science, 177, 811

    Article  PubMed  CAS  Google Scholar 

  46. Cicero, T. J. and Smithloff, B. R. (1973). Alcohol and self administration in rats: Attempts to elicit excessive intake and dependence. In: M. M. Gross (ed.). Advances in Experimental Medicine and Biology, Vol. 35: Alcohol Intoxication and Withdrawal: Experimental Studies. (New York and London: Plenum Press )

    Google Scholar 

  47. Erickson, C. K., Koch, K. I., Mehta, C. S. and McGinity, J. W. (1978). Sustained release of alcohol: Subcutaneous silastic implants in mice. Science, 199, 1457

    Article  PubMed  CAS  Google Scholar 

  48. Craig, J. R., Munsat, T. L. and Chuang, M. (1977). Programmed feeding as a model of chronic alcoholism in the rat. Ann. Neurol, 2, 311

    Article  PubMed  CAS  Google Scholar 

  49. Wilson, J. G. (1973). Environment and Birth Defects, pp. 227–232. ( New York and London: Academic Press )

    Google Scholar 

  50. Reyes, F. I., Boroditsky, R. S., Winter, J. S. D. and Faiman, C. (1974). Studies on human sexual development II: Fetal and maternal serum gonadotropin and sex steroid concentrations. J. Clin. Endocrinol Metab., 38, 612

    Article  PubMed  CAS  Google Scholar 

  51. Leblond, C. and Clermont, Y. (1952). Definition of the stages of the cycle of the semin-iferous epithelium in the rat. Ann. N.Y. Acad. Sci., 55, 548

    Article  PubMed  CAS  Google Scholar 

  52. Croft, B. and Bartke, A. (1976). Quantitative study of spermatogenesis in vasectomized mice. Int. J. Fértil, 21, 61

    PubMed  CAS  Google Scholar 

  53. Vitale, J. J., Di Giorgio, J., McGrath, H., Nay, J. and Hegsted, D. M. (1953). Alcohol oxidation in relation to alcohol dosage and the effect of fasting. J. Biol Chem., 204, 257

    PubMed  CAS  Google Scholar 

  54. Lieber, C. S. (1975). Interference of ethanol in hepatic cellular metabolism. In: F. A. Seixes, K. Williams and S. Eggleston (eds.). Medical Consequences of Alcoholism. Ann. N.Y. Acad. Sci., 252, 24

    Google Scholar 

  55. Stockard, C. R. and Papanicolaou, G. (1916). A further analysis of the hereditary transmission of degeneracy and deformities by the descendants of alcoholized mammals. Am. Nat., 50, Part I, 65–88; Part II, 144–177

    Google Scholar 

  56. Rorvik, D. M. and Shettles, L. B. (1970). Your Baby’s Sex: Now You Can Choose. ( Toronto: Dodd Mead and Co. )

    Google Scholar 

  57. Rösch (1837). Cited by Arlit, A. H. and Wells, H. G. (1917). The effect of alcohol on the reproductive tissues. J. Exp. Med., 26, 769

    Article  Google Scholar 

  58. Mirone, L. (1952). The effect of ethyl alcohol on growth, fecundity and voluntary con-sumption of alcohol by mice. Qu. J. Stud. Ale 13, 365

    CAS  Google Scholar 

  59. Bertholet, E. (1919). Cited in Arlit, A. H. and Wells, H. G. (1917). The effect of alcohol on the reproductive tissues, J. Exp. Med., 26, 769

    Google Scholar 

  60. Bouin and Garnier (1900). Cited in Monterosso, B. (1912). L’azione del diguinoe dell’ apitelio del tubo seminifero del topo. Archiv, de Biol., 27, 35

    Google Scholar 

  61. Reddy, K. and Svoboda, D. (1967). Alterations in rat testes due to an antispermatogenic agent. Arch. Pathol, 84, 376

    PubMed  CAS  Google Scholar 

  62. Doepfmer, R. and Hinckers, H. (1965). Zur Frage der Keimschädigung im akuten Rausch. Z. Haut-u. Geschlechtskr., 39, 94

    CAS  Google Scholar 

  63. Teitelbaum, H. and Gantt, W. (1958). The effect of alcohol on sexual reflexes and sperm count in the dog. Qu. J. Stud. Alcohol, 13, 394

    Google Scholar 

  64. Schopper, K. (1911). Frankfurter Z. Path., 8. Cited in Arlit, A. H. and Wells, H. G. (1917). The effect of alcohol on the reproductive tissues. J. Exp. Med., 26, 769

    Google Scholar 

  65. Badr, F. and Bartke, A. (1974). Effect of ethyl alcohol on plasma testosterone level in mice. Steroids, 23, 921

    Article  PubMed  CAS  Google Scholar 

  66. Levin, J., Lloyd, C., Lobotsky, J. and Friedrich, E. (1967). The effect of epinephrine on testosterone production. Acta Endocrinol., 55, 184

    PubMed  CAS  Google Scholar 

  67. Weddington, S., Hansson, V., Ritzen, E., Hagenas, L., French, F. and Nayfeh, S. (1975). Sertoli cell secretory function after hypophysectomy. Nature (Lond.), 254, 145

    Article  CAS  Google Scholar 

  68. Bregman, A. (1971). Cytogenetic effects of ethanol in human leukocyte cultures. EMS Newsletter, 4, 35

    Google Scholar 

  69. Obe, G. and Herha, J. (1975). Chromosomal damage in chronic alcohol users. Humangenetik, 29, 191

    Article  PubMed  CAS  Google Scholar 

  70. Van Thiel, D., Lester, R. and Sherins, R. (1974). Hypogonadism in alcoholic liver disease: evidence for a double effect. Gastroenterology, 67, 1188

    PubMed  Google Scholar 

  71. Clausen, S. (1938). The pharmacology and therapeutics of vitamin A. J. Am. Med. Ass., 111, 144

    Article  CAS  Google Scholar 

Download references

Authors
  1. R. W. Klassen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. V. N. Persaud
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Anatomy Faculties of Medicine and Dentistry, University of Manitoba, 730 William Avenue, R3E 0W3, Winnipeg, Manitoba, Canada

    T. V. N. Persaud

Rights and permissions

Reprints and permissions

Copyright information

© 1979 MTP Press Limited

About this chapter

Cite this chapter

Klassen, R.W., Persaud, T.V.N. (1979). Experimental studies on the influence of male alcoholism on testicular function, pregnancy and progeny. In: Persaud, T.V.N. (eds) Teratological Testing. Advances in the Study of Birth Defects, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6651-5_13

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-6651-5_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6653-9

  • Online ISBN: 978-94-011-6651-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation