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Experimental studies on the influence of male alcoholism on testicular function, pregnancy and progeny

  • R. W. Klassen
  • T. V. N. Persaud
Part of the Advances in the Study of Birth Defects book series (ASBD, volume 2)

Abstract

The problem of alcohol abuse has reached alarming proportions. Despite the increasing number of reports dealing with the medical, social and economical aspects of alcoholism, the production of alcoholic spirits continues to increase by nearly 10% annually1,2. The relationship of alcohol consumption to disease has been well documented; however, its total involvement indicates the necessity for further investigation3.

Keywords

Sertoli Cell Seminal Vesicle Seminiferous Tubule Fetal Alcohol Syndrome Chronic Alcoholism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    W.H.O. (1975). Alcohol: A growing danger. W.H.O. Chronicle, 29, 102Google Scholar
  2. 2.
    W.H.O. (1975). Problems of non-medical drug use. W.H.O. Chronicle, 29, 97Google Scholar
  3. 3.
    Seixes, F. A., Williams, K. and Eggleston, S. (1975). Medical consequences of alcoholism. Ann. New York Acad. Sci., 252, 10–396CrossRefGoogle Scholar
  4. 4.
    Stockard, C. R. (1910). The influence of alcohol and other anaesthetics on embryonic development. Am. J. Anat., 10, 369CrossRefGoogle Scholar
  5. 5.
    Stockard, C. R. (1912). An experimental study of racial degeneration in mammals treated with alcohol. Arch. Int. Med., 10, 369CrossRefGoogle Scholar
  6. 6.
    Stockard, C. R. and Craig, D. M. (1912). An experimental study of the influence of alcoholism on the germ cells and the developing embryos of mammals. Arch. f. Entwickl., 35, 569CrossRefGoogle Scholar
  7. 7.
    Nice, L. B. (1912). Comparative studies on the effects of alcohol, nicotine, tobacco smoke and caffeine on white mice. I. Effects on reproduction and growth. J. Exp. Zool., 12, 133CrossRefGoogle Scholar
  8. 8.
    Stockard, C. R. (1913). The effect on the offspring of intoxicating the male parent and the transmission of the defects to subsequent generations. Am. Nat., 47, 641CrossRefGoogle Scholar
  9. 9.
    Pearl, R. (1917). The experimental modification of germ cells: The effect of parental alcoholism, and certain other drug intoxications, upon the progeny. J. Exp. Zool., 22, 241CrossRefGoogle Scholar
  10. 10.
    MacDowell, E. C. and Lord, E. M. (1927). Cited in Willis, R. A. ( 1962 ) The Borderland of Embryology and Pathology. (London: Butterworth )Google Scholar
  11. 11.
    Durham, F. M. and Woods, H. M. (1932). Alcohol and inheritance: An experimental study. Med. Res. Coun, Spec. Report Series No. 168 (London)Google Scholar
  12. 12.
    Sandor, S. and Elias, S. (1968). The influence of ethyl-alcohol on the development of the chick embryo. Revue Roumaine dEmbryologie et de Cytologic - Serie Embryologie, 5, 51Google Scholar
  13. 13.
    Sandor, S. (1968). The influence of ethyl alcohol on the developing chick embryo II. Revue Roumaine d Embryologie et de Cytologie - Serie dEmbryologie, 5, 167Google Scholar
  14. 14.
    Sandor, S. and Amels, D. (1971). The action of ethanol on the prenatal development of albino rats. Revue Roumaine dEmbryologie et de Cytologie - Serie dEmbryologie, 8, 37Google Scholar
  15. 15.
    Jones, K. L., Smith, D. W., Streissguth, A. P. and Myrianthopoulos, N. C. (1974). Outcome in offspring of chronic alcoholic women. Lancet, 1, 1076PubMedCrossRefGoogle Scholar
  16. 16.
    Badr, F. and Badr, R. (1975). Induction of dominant lethal mutation in male mice by ethyl alcohol. Nature (Lond.), 253 134CrossRefGoogle Scholar
  17. 17.
    Tenbrinck, M. S. and Buchin, S. Y. (1975). Fetal alcohol syndrome. Report of a case. J. Am. Med. Ass., 232, 1144CrossRefGoogle Scholar
  18. 18.
    Tze, W. J. and Lee, M. (1975). Adverse effects of maternal alcohol consumption on pregnancy and foetal growth in rats. Nature (Lond.), 257, 479CrossRefGoogle Scholar
  19. 19.
    Clarren, S. K. and Smith, D. W. (1978). The fetal alcohol syndrome. N. Eng. J. Med., 298, 1063CrossRefGoogle Scholar
  20. 20.
    Clarren, S. K., Alvord, E. C., Sumi, M., Streissguth, A. P. and Smith, D. W. (1978). Brain malformations related to prenatal exposure to ethanol. J. Pediat., 92, 64PubMedCrossRefGoogle Scholar
  21. 21.
    Lutzen, L. and Ueberberg, H. (.1973J. A study on morphological changes in the testes of old albino rats. Beitr. Path., 149, 377Google Scholar
  22. 22.
    Stearns, E. L., MacDonnell, J. A., Kaufman, B. J., Padua, R., Lucman, T. S., Winter, J. S. D. and Faiman, C. (1974). Declining testicular function with age. Am. J. Med., 57, 761PubMedCrossRefGoogle Scholar
  23. 23.
    Siperstein, D. (1920). The effects of acute and chronic inanition upon the development and structure of the testis in the albino rat. Anat. Rec., 20, 355CrossRefGoogle Scholar
  24. 24.
    Mauer, S. and Mason, K. (1975). Antisterility activity of d-cr-tocopheryl hydroquinone in the vitamin E-deficient male hamster and rat. J. Nutr., 105, 491PubMedGoogle Scholar
  25. 25.
    Bowler, K. (1972). The effect of repeated applications of heat on-spermatogenesis in the rat: a histological study. J. Reprod. Fertil, 28, 325PubMedCrossRefGoogle Scholar
  26. 26.
    Hildebrand, D., Der, R., Griffin, W. and Fahim, M. (1973). Effect of lead acetate on reproduction. Am. J. Obstet. Gynecol., 115, 1058Google Scholar
  27. 27.
    Lee, I. and Dixon, R. (1973). Effects of cadmium on spermatogenesis studied by velocity sedimentation cell separation and serial mating. J. Pharmacol. Exp. Ther., 187, 641PubMedGoogle Scholar
  28. 28.
    Cooper, E., Jones, A. and Jackson, H. (1974). Effects of a-chlorohydrin and related compounds on the reproductive organs and fertility of the male rat. J. Reprod. Fertil., 28, 379Google Scholar
  29. 29.
    Ahluwalia, R., Gambhir, K. and Sekhon, H. (1975). Distribution of labeled retinyl acetate and retinolic acid in rat and human testes. A site of retinyl acetate incorporation in rat testes. J. Nutr., 105, 467PubMedGoogle Scholar
  30. 30.
    Cicero, T., Bell, R., Wiest, W., Allison, J., Polakoski, K. and Robins, E. (1975). Function of the male sex organs in heroin and methadone users. N. Eng. J. Med., 292, 882CrossRefGoogle Scholar
  31. 31.
    Kalla, N. and Bansal, M. (1975). Effect of carbon tetrachloride on gonadal physiology in male rats. Acta Anat 91, 380PubMedCrossRefGoogle Scholar
  32. 32.
    Nagy, F. and Edmonds, R. (1975). Cellular proliferation and renewal in the various zones of the hamster epididymis after colchicine administration. Fértil. Steril., 26, 460PubMedGoogle Scholar
  33. 33.
    Urry, R. and Dougherty, K. (1975). Inhibition of rat spermatogenesis and seminiferous tubule growth after short-term and long-term administration of a monoamine oxidase inhibitor. Fértil. Steril, 26, 232PubMedGoogle Scholar
  34. 34.
    Arlit, A. H. and Wells, H. G. (1917). The effect of alcohol on the reproductive tissues. J. Exp. Med., 26, 769CrossRefGoogle Scholar
  35. 35.
    Van Thiel, D., Cavaler, J., Lester, R. and Goodman, M. (1975). Alcohol-induced testicular atrophy. Gastroenterology, 69, 326PubMedGoogle Scholar
  36. 36.
    Lutwak-Mann, C. (1964). Observations on progeny of thalidomide treated male rabbits. Br. Med. J., 1, 1090PubMedCrossRefGoogle Scholar
  37. 37.
    Clay, M. L. (1964). Conditions affecting voluntary alcohol consumption in rats. Qu. J. Stud. Alcohol, 25, 36Google Scholar
  38. 38.
    Myers, R. D. (1966). Voluntary alcohol consumption in animals: Peripheral and intra-cerebral factors. Psychosom. Med., 28, 484Google Scholar
  39. 39.
    Essig, C. F. and Lam, R. C. (1968). Convulsions and hallucinatory behaviour following alcohol withdrawal in the dog. Arch. Neurol., 18, 626PubMedCrossRefGoogle Scholar
  40. 40.
    Deneau, G., Yanagita, T. and Seevers, M. R. (1969). Self administration of psychoactive substances by the monkey. Psychopharmacologie, 16, 30CrossRefGoogle Scholar
  41. 41.
    Freund, G. (1969). Alcohol withdrawal syndrome in mice. Arch. Neurol, 21, 315PubMedCrossRefGoogle Scholar
  42. 42.
    Goldstein, D. B. and Pal, N. (1971). Alcohol dependence produced in mice by inhalation of ethanol: Grading the withdrawal reaction. Science, 172, 288PubMedCrossRefGoogle Scholar
  43. 43.
    Ellis, F. W. and Pick, J. R. (1970). Experimentally induced ethanol dependence in Rhesus monkeys. J. Pharmacol Exp. Ther., 175, 88PubMedGoogle Scholar
  44. 44.
    Woods, J. H., Ikomi, F. and Winger, G. D. (1971). The reinforcing property of ethanol. In: M. K. Rooch, W. M. Mclssac and P. J. Creaven (eds.). Biological Aspects of Alcohol, pp. 371–388. ( Texas: Austin University Texas Press )Google Scholar
  45. 45.
    Falk, J. L., Samson, H. and Winger, G. (1972). Behavioural maintenance of high concentrations of blood ethanol and physical dependence in the rat. Science, 177, 811PubMedCrossRefGoogle Scholar
  46. 46.
    Cicero, T. J. and Smithloff, B. R. (1973). Alcohol and self administration in rats: Attempts to elicit excessive intake and dependence. In: M. M. Gross (ed.). Advances in Experimental Medicine and Biology, Vol. 35: Alcohol Intoxication and Withdrawal: Experimental Studies. (New York and London: Plenum Press )Google Scholar
  47. 47.
    Erickson, C. K., Koch, K. I., Mehta, C. S. and McGinity, J. W. (1978). Sustained release of alcohol: Subcutaneous silastic implants in mice. Science, 199, 1457PubMedCrossRefGoogle Scholar
  48. 48.
    Craig, J. R., Munsat, T. L. and Chuang, M. (1977). Programmed feeding as a model of chronic alcoholism in the rat. Ann. Neurol, 2, 311PubMedCrossRefGoogle Scholar
  49. 49.
    Wilson, J. G. (1973). Environment and Birth Defects, pp. 227–232. ( New York and London: Academic Press )Google Scholar
  50. 50.
    Reyes, F. I., Boroditsky, R. S., Winter, J. S. D. and Faiman, C. (1974). Studies on human sexual development II: Fetal and maternal serum gonadotropin and sex steroid concentrations. J. Clin. Endocrinol Metab., 38, 612PubMedCrossRefGoogle Scholar
  51. 51.
    Leblond, C. and Clermont, Y. (1952). Definition of the stages of the cycle of the semin-iferous epithelium in the rat. Ann. N.Y. Acad. Sci., 55, 548PubMedCrossRefGoogle Scholar
  52. 52.
    Croft, B. and Bartke, A. (1976). Quantitative study of spermatogenesis in vasectomized mice. Int. J. Fértil, 21, 61PubMedGoogle Scholar
  53. 53.
    Vitale, J. J., Di Giorgio, J., McGrath, H., Nay, J. and Hegsted, D. M. (1953). Alcohol oxidation in relation to alcohol dosage and the effect of fasting. J. Biol Chem., 204, 257PubMedGoogle Scholar
  54. 54.
    Lieber, C. S. (1975). Interference of ethanol in hepatic cellular metabolism. In: F. A. Seixes, K. Williams and S. Eggleston (eds.). Medical Consequences of Alcoholism. Ann. N.Y. Acad. Sci., 252, 24Google Scholar
  55. 55.
    Stockard, C. R. and Papanicolaou, G. (1916). A further analysis of the hereditary transmission of degeneracy and deformities by the descendants of alcoholized mammals. Am. Nat., 50, Part I, 65–88; Part II, 144–177Google Scholar
  56. 56.
    Rorvik, D. M. and Shettles, L. B. (1970). Your Baby’s Sex: Now You Can Choose. ( Toronto: Dodd Mead and Co. )Google Scholar
  57. 57.
    Rösch (1837). Cited by Arlit, A. H. and Wells, H. G. (1917). The effect of alcohol on the reproductive tissues. J. Exp. Med., 26, 769CrossRefGoogle Scholar
  58. 58.
    Mirone, L. (1952). The effect of ethyl alcohol on growth, fecundity and voluntary con-sumption of alcohol by mice. Qu. J. Stud. Ale 13, 365Google Scholar
  59. 59.
    Bertholet, E. (1919). Cited in Arlit, A. H. and Wells, H. G. (1917). The effect of alcohol on the reproductive tissues, J. Exp. Med., 26, 769Google Scholar
  60. 60.
    Bouin and Garnier (1900). Cited in Monterosso, B. (1912). L’azione del diguinoe dell’ apitelio del tubo seminifero del topo. Archiv, de Biol., 27, 35Google Scholar
  61. 61.
    Reddy, K. and Svoboda, D. (1967). Alterations in rat testes due to an antispermatogenic agent. Arch. Pathol, 84, 376PubMedGoogle Scholar
  62. 62.
    Doepfmer, R. and Hinckers, H. (1965). Zur Frage der Keimschädigung im akuten Rausch. Z. Haut-u. Geschlechtskr., 39, 94Google Scholar
  63. 63.
    Teitelbaum, H. and Gantt, W. (1958). The effect of alcohol on sexual reflexes and sperm count in the dog. Qu. J. Stud. Alcohol, 13, 394Google Scholar
  64. 64.
    Schopper, K. (1911). Frankfurter Z. Path., 8. Cited in Arlit, A. H. and Wells, H. G. (1917). The effect of alcohol on the reproductive tissues. J. Exp. Med., 26, 769Google Scholar
  65. 65.
    Badr, F. and Bartke, A. (1974). Effect of ethyl alcohol on plasma testosterone level in mice. Steroids, 23, 921PubMedCrossRefGoogle Scholar
  66. 66.
    Levin, J., Lloyd, C., Lobotsky, J. and Friedrich, E. (1967). The effect of epinephrine on testosterone production. Acta Endocrinol., 55, 184PubMedGoogle Scholar
  67. 67.
    Weddington, S., Hansson, V., Ritzen, E., Hagenas, L., French, F. and Nayfeh, S. (1975). Sertoli cell secretory function after hypophysectomy. Nature (Lond.), 254, 145CrossRefGoogle Scholar
  68. 68.
    Bregman, A. (1971). Cytogenetic effects of ethanol in human leukocyte cultures. EMS Newsletter, 4, 35Google Scholar
  69. 69.
    Obe, G. and Herha, J. (1975). Chromosomal damage in chronic alcohol users. Humangenetik, 29, 191PubMedCrossRefGoogle Scholar
  70. 70.
    Van Thiel, D., Lester, R. and Sherins, R. (1974). Hypogonadism in alcoholic liver disease: evidence for a double effect. Gastroenterology, 67, 1188PubMedGoogle Scholar
  71. 71.
    Clausen, S. (1938). The pharmacology and therapeutics of vitamin A. J. Am. Med. Ass., 111, 144CrossRefGoogle Scholar

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© MTP Press Limited 1979

Authors and Affiliations

  • R. W. Klassen
  • T. V. N. Persaud

There are no affiliations available

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