Advertisement

Primate teratology: selection of species and future use

  • A. G. Hendrickx
  • P. E. Binkerd
Part of the Advances in the Study of Birth Defects book series (ASBD, volume 2)

Abstract

The devastating effects of the thalidomide episode of several years ago has led to a wide search for suitable animal models in which to study the aetiology of human birth defects. With the discovery that several species of nonhuman primates showed unusual similarities to the thalidomide malformation syndrome in man at comparable doses and similar exposure periods during early development, this order of mammals was scrutinized more closely for its potential as an animal model for teratological studies.

Keywords

Rhesus Monkey Nonhuman Primate Primate Species Human Embryo World Monkey 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Wilson, J. G. (1973). Environment and Birth Defects. ( New York: Academic Press )Google Scholar
  2. 2.
    Wilson, J. G. and Fraser, F. C. (eds.). (1977). Handbook of Teratology, Vol. I, General Principles and Etiology, (New York and London: Plenum Press )Google Scholar
  3. 3.
    Butler, H. (1974). Evolutionary trends in primate sex cycles. Contrib. Primal., 3, 2Google Scholar
  4. 4.
    Wright, E. M., Jr. and Bush, D. E. (1977). The reproductive cycle of the capuchin (Cebus apella). Lab. Anim. Sci 27, 651PubMedGoogle Scholar
  5. 5.
    Hearn, J. P. and Lunn, S. F. (1975). The reproductive biology of the marmoset monkey, Callithrix jacchus. Lab. Anim. Handb., 6, 191Google Scholar
  6. 6.
    Srivastava, P. K., Cavazos, F. and Lucas, F. V. (1970). Biology of reproduction in the squirrel monkey (Saimiri sciureus). I. The estrus cycle. Primates, 11, 125CrossRefGoogle Scholar
  7. 7.
    Eaton, G. G., Slob, A. and Resko, J. A. (1973). Cycles of mating behaviour, oestrogen and progesterone in the thick-tailed bushbaby (Galago crassicaudatus crassicaudatus) under laboratory conditions. Anim. Behav., 21, 309PubMedCrossRefGoogle Scholar
  8. 8.
    Bogart, M. H., Kumamoto, A. T. and Lasley, B. L. (1977). A comparison of the reproductive cycle in three species of lemur. Folia Primat., 28, 134CrossRefGoogle Scholar
  9. 9.
    Stabenfeldt, G. H. and Hendrickx, A. G. (1973). Progesterone levels in the sooty mangabey (Cercocebus atys) during the menstrual cycle, pregnancy and parturition. J. Med. Primat., 2, 1Google Scholar
  10. 10.
    Stabenfeldt, G. H. and Hendrickx, A. G. (1973). Progesterone studies in the Macaca fascicularis. Endocrinology, 92, 1296PubMedCrossRefGoogle Scholar
  11. 11.
    Atkinson, L. E., Hotchkiss, I., Fritz, G. R., Surve, A. H., Neill, J. D. and Knobil, E. (1975). Circulating levels of steroids and chorionic gonadotrophin during pregnancy in the rhesus monkey, with special attention to the rescue of the corpus luteum in early pregnancy. Biol. Reprod., 12, 335PubMedCrossRefGoogle Scholar
  12. 12.
    Stabenfeldt, G. H. and Hendrickx, A. G. (1972). Progesterone levels in the bonnet monkey (.Macaca radiata) during the menstrual cycle and pregnancy. Endocrinology, 91, 614PubMedCrossRefGoogle Scholar
  13. 13.
    Kling, O. R. and Westfahl, P. K. (1978). Steroid changes during the menstrual cycle of the baboon (Papio cynocephalus) and human. Biol. Reprod., 18, 392PubMedCrossRefGoogle Scholar
  14. 14.
    Graham, C. E., Collins, D. C., Robinson, H. and Preedy, J. R. K. (1972). Urinary levels of estrogen and pregnanediol and plasma levels of progesterone during the menstrual cycle of the chimpanzee: Relation to the sexual swelling. Endocrinology, 91, 13PubMedCrossRefGoogle Scholar
  15. 15.
    Shackleton, C. H. L. and Mitchell, F. L. (1975). The comparison of perinatal steroid endocrinology in simians with a view to finding a suitable animal model to study human problems. Lab. Anim. Handb., 6, 159Google Scholar
  16. 16.
    Tullner, W. W. (1974). Comparative aspects of primate chorionic gonadotropins. Contrib. Primat., 3, 235Google Scholar
  17. 17.
    Luckett, W. P. (1974). Comparative development and evolution of the placenta in primates. Contrib. Primat., 3, 142Google Scholar
  18. 18.
    Hendrickx, A. G. and Houston, M. L. (1971). Prenatal and postnatal development. In: E. S. E. Hafez (ed.). Comparative Reproduction of Nonhuman Primates, pp. 334–381. (Springfield, 111.: Charles C. Thomas )Google Scholar
  19. 19.
    Butler, H. (1967). The giant cell trophoblast of the Senegal galago (Galago senegalensis senegalensis) and its bearing on the evolution of the primate placenta. J. Zool., Lond 152, 195CrossRefGoogle Scholar
  20. 20.
    Schwaier, A. and Kuhn, H. J. (1975). Chronology of the development of embryo and placenta of Tupaia belangeri. Lab. Anim. Handb., 6, 257Google Scholar
  21. 21.
    Hill, J. P. (1932). The developmental history of the primates. Phil. Trans. Royal Soc. Lond. Ser. (B), 221, 45CrossRefGoogle Scholar
  22. 22.
    Hendrickx, A. G. (1972). Early development of the embryo in non-human primates and man. Acta Endocrinol., Kbh., 166 (Suppl.), 103Google Scholar
  23. 23.
    Butler, H. (1972). The chronology of embryogenesis in the lesser galago: A preliminary account. Folia Primat., 18, 368CrossRefGoogle Scholar
  24. 24.
    Hendrickx, A. G., Houston, M. L., Kraemer, D. C., Gasser, R. F. and Bollert, J. A. (1971). Embryology of the Baboon. ( Chicago and London: The University of Chicago Press )Google Scholar
  25. 25.
    Heuser, C. H. and Streeter, G. L. (1941). Development of the macaque embryo. Contrib. Embryol, Carnegie Inst. Washington, 29, 17Google Scholar
  26. 26.
    Hendrickx, A. G. and Sawyer, R. H. (1975). Embryology of the rhesus monkey. In: G. Bourne (ed.). The Rhesus Monkey. Vol. II, Management, Reproduction, and Pathology, pp. 141–169. ( New York: Academic Press )Google Scholar
  27. 27.
    Hendrickx, A. G., Sawyer, R. H., Lasley, B. L. and Barnes, R. D. (1975). Comparison of developmental stages in primates with a note on the detection of ovulation. Lab. Anim. Handb., 6, 305Google Scholar
  28. 28.
    Hendrickx, A. G. (1972). A comparison of temporal factors in the embryological development of man, Old World monkeys and galagos, and craniofacial malformations induced by thalidomide and triamcinolone. In: E. I. Goldsmith and J. Moor-Jankowski (eds.). Medical Primatology 1972. Part III, pp. 259–269. ( Basel: Karger )Google Scholar
  29. 29.
    Streeter, G. L. (1942). Developmental horizons of human embryos: Description of age group XI, 13–20 somites, and age group XII, 21–29 somites. Contrib. Embryol., Carnegie Inst., Washington, 30, 211Google Scholar
  30. 30.
    Streeter, G. L. (1945). Developmental horizons in human embryos: Description of age group XIII, embryos about 4 or 5 millimeters long, and age group XIV, period of indentation of the lens vesicle. Contrib. Embryol., Carnegie Inst., Washington, 31, 27Google Scholar
  31. 31.
    Streeter, G. L. (1948). Developmental horizons in human embryos: Description of age groups XV, XVI, XVII, and XVIII, being the third issue of a survey of the Carnegie Collection. Contrib. Embryol, Carnegie Inst., Washington, 32, 135Google Scholar
  32. 32.
    Streeter, G. L. (1951). Developmental horizons in human embryos: Description of age groups XIX, XX, XXI, XXII, and XXIII, being the fifth issue of a survey of the Carnegie Collection. Contrib. Embryol, Carnegie Inst., Washington, 34, 165Google Scholar
  33. 33.
    Nishimura, H., Takano, K., Tanimura, T. and Yasuda, M. (1968). Normal and abnormal development of human embryos: First report of the analysis of 1213 intact embryos. Teratology, 1, 281PubMedCrossRefGoogle Scholar
  34. 34.
    Wilson, J. G. (1972). Abnormalities of intra-uterine development in non-human primates. Acta Endocrinol, Kbh., 166 (Suppl.), 261Google Scholar
  35. 35.
    Hendrickx, A. G., Terrell, T. G., Andersen, A. C., Osburn, B. I., Sawyer, R. H. and Steffek, A. J. (1977). Induction of abnormal intra-uterine development with triamcinolone, vitamin A and X-irradiation in non-human primates. In: M. R. N. Prasad and T. C. Anand Kumar (eds.). Use of Non-Human Primates in Biomedical Research, pp. 149–169. ( New Delhi: Indian National Science Academy )Google Scholar
  36. 36.
    Hendrickx, A. G. and Sawyer, R. H. (1978). Developmental staging and thalidomide teratogenicity in the green monkey (Cercopithecus aethiops). Teratology, 18, 393PubMedCrossRefGoogle Scholar
  37. 37.
    Butler, H. (1977). The effect of thalidomide on a prosimian: The greater galago (Galago crassicaudatus). J. Med. Primat., 6, 319Google Scholar
  38. 38.
    Esaki, K., Tanioka, Y., Ogata, T. and Koizumi, H. (1975). Effect of sodium dipropy- lacetate (Dpa) on rhesus monkey fetuses. CIEA (Cent. Inst. Exp. Anim) Preclin. Rep., 1, 157Google Scholar
  39. 39.
    Wilson, J. G. (1974). Teratologic causation in man and its evaluation in non-human pri-mates. In: A. G. Motulsky and W. Lenz (eds.). Birth Defects, pp. 191–203. ( Amsterdam: Excerpta Medica )Google Scholar
  40. 40.
    Ulfelder, H. (1976). DES - transplacental teratogen - and possibly also carcinogen. Teratology, 13, 101PubMedCrossRefGoogle Scholar
  41. 41.
    Robboy, S. J., Scully, R. E. and Herbst, A. L. (1975). Pathology of vaginal and cervical abnormalities associated with prenatal exposure to diethylstilbestrol (DES). J. Reprod. Med., 15, 13PubMedGoogle Scholar
  42. 42.
    Bibbo, M., Gill, W. B., Azizi, F., Blough, R., Fang, V. S., Rosenfield, R. L., Schumacher, G. F. B., Sleeper, K., Sonek, M. G. and Wied, G. L. (1977). Follow-up study of male and female offspring of DES-exposed mothers. Obstet. Gynecol, 49, 1PubMedGoogle Scholar
  43. 43.
    Cosgrove, M. D., Benton, B. and Henderson, B. E. (1977). Male genitourinary abnor-malities and maternal diethylstilbestrol. J. Urology, 117, 220Google Scholar
  44. 44.
    Hendrickx, A. G., Benirschke, K., Thompson, R. S., Ahern, J., Lucas, W. E. and Oi, R. (1978). The effects of prenatal diethylstilbestrol (DES) exposure on the genitalia of pubertal Macaca mulatto. Teratology, 17, 23 A (Abstract)Google Scholar
  45. 45.
    Szabo, K. T., DiFebbo, M. E., Kang, Y. J., Palmer, A. K. and Brent, R. L. (1975). Comparative embryotoxicity and teratogenicity of various tranquilizing agents in mice, rats, rabbits, and rhesus monkeys. Toxicol. Appl. Pharmacol., 33, 124 (Abstract)Google Scholar
  46. 46.
    Jackson, B. A., Rodwell, D. E., Kanegis, L. A. and Noble, J. F. (1975). Effect of maternally administered minocycline on embryonic and fetal development in the rhesus monkey (Macaca mulatto). Toxicol. Appl. Pharmacol., 33, 156Google Scholar
  47. 47.
    Hendrickx, A. G. (1975). Teratologic evaluation of imipramine hydrochloride in bonnet (Macaca radiata) and rhesus monkeys (Macaca mulatto). Teratology, 11, 219PubMedCrossRefGoogle Scholar
  48. 48.
    Hendrickx, A, G., Sawyer, R. H., Terrell, T. G., Osburn, B. I., Henrickson, R. V. and Steffek, A. J. (1975). Teratogenic effects of triamcinolone on the skeletal and lymphoid systems in nonhuman primates. Fed. Proc., 34, 1661Google Scholar
  49. 49.
    Fantel, A. G., Shepard, T. H., Newell-Morris, L. L. and Moffett, B. C. (1977). Teratogenic effects of retinoic acid in pigtail monkeys (Macaca nemestrina). I. General features. Teratology, 15, 65PubMedCrossRefGoogle Scholar
  50. 50.
    Reynolds, W. A. and Pitkin, R. M. (1975). Methylmercury toxicity in utero in the macaque. J. Med. Primat., 4, 372 (Abstract)Google Scholar
  51. 51.
    Poswillo, D. E., Sopher, D. and Mitchell, S. J. (1972). Experimental induction of foetal malformation with blighted potato: A preliminary report. Nature (Lond.), 239, 462CrossRefGoogle Scholar
  52. 52.
    Poswillo, D. E., Sopher, D., Mitchell, S. J., Coxon, D. T., Curtis, R. F. and Price, K. R. (1973). Investigation into the teratogenic potential of imperfect potatoes. Teratology, 8, 339PubMedCrossRefGoogle Scholar
  53. 53.
    Allen, J. R., Marlar, R. J., Chesney, C. F., Helgeson, J. P., Kelman, A., Weckel, K. G., Traisman, E. and White, J. W., Jr. (1972). Teratogenicity studies on late blighted potatoes in nonhuman primates (Macaca mulatto and Saguinus labiatus). Teratology, 15, 17CrossRefGoogle Scholar
  54. 54.
    Vondruska, J. F., Fancher, O. E. and Calandra, J. C. (1971). An investigation into the teratogenic potential of captan, folpet, and difolatan in nonhuman primates. Toxicol. Appl. Pharmacol, 18, 619PubMedCrossRefGoogle Scholar
  55. 55.
    Dougherty, W. J., Herbst, M. and Coulston, F. (1975). The non-teratogenicity of 2,4,5- trichlorophenoxyacetic acid in the rhesus monkey (Macaca mulatto). Bull. Environ. Contam. Toxicol., 13, 477PubMedCrossRefGoogle Scholar
  56. 56.
    Kurent, J. E. and Sever, J. L. (1977). Infectious diseases. In: J. G. Wilson and F. C. Fraser (eds.). Handbook of Teratology, pp. 225–259. ( New York and London: Plenum Press )Google Scholar
  57. 57.
    London, W. T., Fuccillo, D. A., Sever, J. L. and Kent, S. G. (1975). Influenza virus as a teratogen in rhesus monkeys. Nature (Lond.), 255, 483CrossRefGoogle Scholar
  58. 58.
    London, W. T., Levitt, N. H., Kent, S. G., Wong, V. G. and Sever, J. L. (1977). Con-genital cerebral and ocular malformations induced in rhesus monkeys by Venezuelan equine encephalitis virus. Teratology, 16, 285PubMedCrossRefGoogle Scholar
  59. 59.
    Andersen, A. C., Hendrickx, A. G. and Momeni, M. H. (1977). Fractionated X-radiation damage to developing ovaries in the bonnet monkey (Macaca radiata). Radiat. Res., 71, 398PubMedCrossRefGoogle Scholar
  60. 60.
    Miller, P., Smith, D. W. and Shepard, T. H. (1978). Maternal hyperthermia as a possible cause of anencephaly. Lancet, 1, 519PubMedCrossRefGoogle Scholar
  61. 61.
    Hendrickx, A. G. and Stone, G. W. (1976). Preliminary studies on the embryotoxicity of hyperthermia in the bonnet monkey (Macaca radiata). Teratology, 13, 24A (Abstract)Google Scholar
  62. 62.
    Poswillo, D., Nunnerly, H., Sopher, D. and Keith, J. (1974). Hyperthermia as a teratogenic agent. Ann. Royal Coll. Surg. Engl., 55, 171Google Scholar
  63. 63.
    Smith, C. C. (1969). Value of nonhuman primates in predicting disposition of drugs in man. Ann. N.Y. Acad. Sci., 162, 604PubMedCrossRefGoogle Scholar
  64. 64.
    Smith, R. L. and Williams, R. T. (1974). Comparative metabolism of drugs in man and monkeys. J. Med. Primat., 3, 138Google Scholar
  65. 65.
    Smith, R. L. and Caldwell, J. (1977). Drug metabolism in non-human primates. In: D. V. Parke and R. L. Smith (eds.). Drug Metabolism from Microbe to Man, pp. 331–356. ( London: Taylor and Francis, Ltd. )Google Scholar
  66. 66.
    Clifford, J. M. (1977). Drug disposition and effect in sub-human primates used in pharmacology. Comp. Biochem. Physiol., 57C, 1Google Scholar
  67. 67.
    Krauer, B. and Krauer, F. (1977). Drug kinetics in pregnancy. Clin. Pharmacokin 2, 167CrossRefGoogle Scholar
  68. 68.
    Nishimura, H. (1973). Comparative study on maternal-embryonic transfer of drugs in man and laboratory animals. In: L. O. Boreus (ed.). Fetal Pharmacology, pp. 47–53. ( New York: Raven Press )Google Scholar
  69. 69.
    Wilson, J. G., Scott, W. J. and Ritter, E. J. (1975). Comparative distribution of teratogenic drugs in pregnant rats and rhesus monkeys. In: D. Neubert and H. J. Merker (eds.). New Approaches to the Evaluation of Abnormal Embryonic Development, pp. 311–325. ( Stuttgart: Thieme Verlag )Google Scholar
  70. 70.
    Wilson, J. G., Scott, W. J., Ritter, E. J. and Fradkin, R. (1975). Comparative distribution and embryotoxicity of hydroxyurea in pregnant rats and rhesus monkeys. Teratölogy, 11, 169PubMedCrossRefGoogle Scholar
  71. 71.
    Wilson, J. G., Ritter, E. J., Scott, W. J. and Fradkin, R. (1977). Comparative distribution and embryotoxicity of acetylsalicylic acid in pregnant rats and rhesus monkeys. Toxicol. Appl. Pharmacol., 41, 67PubMedCrossRefGoogle Scholar

Copyright information

© MTP Press Limited 1979

Authors and Affiliations

  • A. G. Hendrickx
  • P. E. Binkerd

There are no affiliations available

Personalised recommendations