Abstract
In a previous paper Dr Grant (1973) described the biosynthesis of the collagen molecule. The object of this paper is to discuss what happens extracellularly subsequent to the biosynthesis of the collagen molecule; in other words, what holds the molecule together to maintain the integrity of the fibre and, at the same time, gives the collagen fibre its high tensile strength. It is this high tensile strength of the fibre that permits collagen to act as the major mechanical supporting component of the body. Indeed, the role of collagen in the body is almost, but not entirely, mechanical (Harkness, 1961).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bailey, A. J. (1968) In Comprehensive Biochemistry, Vol. 26B, p. 297. Eds. M. Florkin and E. H. Stotz. Amsterdam: Elsevier Publishing Co.
Bailey, A. J. and Peach, C. M. (1968) Biochemical and Biophysical Research Communications, 38, 812.
Bailey, A. J., Peach, C. M. and Fowler, L. J. (1969) In Chemistry and Molecular Biology of the Intracellular Matrix, Vol. 1, p. 385. Ed. E. A. Balazs. New York: Academic Press.
Bailey, A. J. and Lapière, CH. M. (1973) European Journal of Biochemistry, 34, 91.
Balian, G. and Bailey, A. J. (1975) Annals of Rheumatic Disease (In Press).
Beighton, P. (1970) In The Ehlers—Danlos Syndrome. London: William Heinemann Medical Books Ltd.
Carnes, W. H. (1968) International Reviews of Connective Tissue Research, 4, 197.
Danks, D. M., Campbell, P. E., Walker-Smith, J., Stevens, B. J., Gillespie, J. M., Blomfield, J. and Turner, B. (1972) Lancet, I,1100.
Davis, N. R. and Bailey, A. J. (1971) Biochemical and Biophysical Research Communications, 45, 1316.
Eyre, D. R. and Glimcher, M. J. (1972) Proceedings of the National Academy of Sciences of the United States of America, 69, 2594.
Graham, R. and Beighton, P. (1969) Annals of the Rheumatic Diseases, 28, 248.
Harkness, R. D. (1961) Biological Reviews of the Cambridge Philosophical Society, 36, 399.
Harris, E. D. and Sjoerdsma, A. (1966) Lancet, 11, 707.
Jansen, L. H. (1958) Dermatologica, 110, 108.
Krane, S. M., Pinnell, S. R. and Erbe, R. W. (1972) Proceedings of the National Academy of Sciences of the United States of America, 69, 2899.
Laitinen, O., Ãœitto, J., Livanaisen, M., Hannuksela, M. and Kivirikko, K. (1968) Clinica chimica acta, 21, 321.
Layman, D. L., Narayanan, A. S. and Martin, S. R. (1972) Archives of Biochemistry and Biophysics, 149, 97.
Lenaers, A., Ansay, M., Nusgens, B. V. and Lapière, Ch. M. (1971) European Journal of Biochemistry,2 3, 535.
Levene, C. I. and Gross, J. (1959) Journal of Experimental Medicine, 110, 771.
Macek, M., Kurych, J., Chvapil, M. and Kadlecova, V. (1966) Humangenetik, 3, 87.
Mechanic, G., Gallop, P. M. and Tanzer, M. (1971) Biochemical and Biophysical Research Communications, 45, 644.
Mechanic, G. (1972) Biochemical and Biophysical Research Communications, 47, 267.
Menkes, J. H., Alter, M., Steigleder, S. K., Weakly, D. R. and Sung, J. H. (1962) Pediatrics, 29, 764.
Mckusick, V. A. (1972) In Heritable disorders of connective tissue. St. Louis: C. V. Mosby.
Nimni, M. E. (1968) Journal of Biological Chemistry,243,1 457.
Partridge, S. M., Elsden, D. F., Thomas, J., Dorfman, A., Telser, A. and PEI-LEE, H.(1964) Biochemical Journal,93, 300.
Pinnell, S. R., Krane, S. M., Kenzora, J. and Glimcher, M. J. (1972) New England Journal of Medicine, 286, 1013.
Priest, R. E., Moinuddin, J. F., and Priest, J. H. (1973) Federation Proceedings,345.
Ramachandran, G. (1968) In Treatise on Collagen, Vols. 1–2. New York: Academic Press.
Robins, S. P. and Bailey, A. J. (1973) Federation of European Biochemical Societies Letters, 33, 167.
Robins, S. P., Shimokomaki, M. and Bailey, A. J. (1973) Biochemical Journal, 131, 771.
Rollhauser, H. (1950) Gegenbaurs morphologische Jahrbuch, 90, 249.
Tanzer, M. L., Housely, T., Berube, L., Fairweather, R., Franzblau, C. and Gallop, P. M. (1973) Journal of Biological Chemistry, 248, 393.
Traub, W. and Piez, K. A. (1971) Advances in Protein Chemistry, 25, 243.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Medical and Technical Publishing Co. Ltd.
About this chapter
Cite this chapter
Bailey, A.J. (1975). Biosynthesis of collagen cross-links: Relationship of heritable disorders. In: Holton, J.B., Ireland, J.T. (eds) Inborn Errors of Skin, Hair and Connective Tissue. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6615-7_8
Download citation
DOI: https://doi.org/10.1007/978-94-011-6615-7_8
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-6617-1
Online ISBN: 978-94-011-6615-7
eBook Packages: Springer Book Archive