Abstract
We previously reported that rats, immunized orally (intragastrically) with 200 mg human serum albumin (HSA) displayed a significantly decreased serum antibody response to a subsequent parenteral injection of HSA (André et al., 1977). In addition, such rats had a reduced intestinal absorption of a tracer dose of HSA (André et al., 1974). Anti-HSA antibodies of the IgA class were detected in their intestinal secretions as well as in the cytoplasm of some of their gut plasma cells, as shown by immunofluorescence (André et al., 1977). Moreover, when a test dose of labelled HSA was mixed with intestinal secretions from orally immunized rats, there was a significant decrease of the absorption of the labelled HSA as compared to that of the same dose mixed with normal intestinal contents (André et al., 1974).
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References
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André, C., André, F., Vaerman, J.P. (1978). Biological function of antigen—IgA antibody complexes: in vivo and in vitro interference with intestinal absorption and tolerogenic effect. In: Hemmings, W.A. (eds) Antigen Absorption by the Gut. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6609-6_8
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DOI: https://doi.org/10.1007/978-94-011-6609-6_8
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-6611-9
Online ISBN: 978-94-011-6609-6
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