Abstract
For the past 6 years a research team headed by Professor G. N. Cooper has studied the immunology and microbiology of the gastrointestinal tract. The immune response of animals following injection of antigen into the small intestine had earlier been investigated by Robertson and Cooper 1972, 1973; Cooper et al., 1967; Cooper and Thonard, 1967 who demonstrated that following antigenic stimulation via the intestinal epithelium, the splenic response contributed most to the circulating antibody responses of rats. However, with a technique enumerating rosette-forming cells in dispersed suspensions of lymphoid cells from mesenteric lymph nodes, intestinal lamina propria and submucosal tissues, these workers detected significant increases in the level of cells synthesizing the three major classes of immunoglobulins in local and peripheral lymphoid tissue.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Boyden, S. V. (1966). Natural antibodies and the immune response. Adv. Immunol., 5, 1
Cooper, G. N., Halliday, W. J. and Thonard, J. C. (1967). Immunological reactivity associated with antigens in the intestinal tract of rats. J. Path. Bact., 93, 223
Cooper, G. N. and Thonard, J. C. (1967). Serum antibody responses to intestinal implantation of antigens in rats. J. Path. Bact., 93, 213
Davis, C. P., Mulcahy, D., Takeuchi, A. and Savage, D. C. (1972). Location and description of spiral-shaped microorganisms in the normal rat caecum. Infect. Immun. 6, 184
Foo, M. C., Lee, A. and Cooper, G. N. (1974). Natural antibodies and the intestinal flora of rodents. Aust. J. Exp. Biol. Sci., 52, 321
Kunin, C. M., Beard, M. V. and Malmagyi, H. E. (1962). Evidence for a common hapten associated with enterotoxin fraction of E. coli and other Enterobacteriaceae. Proc. Soc. Exp. Biol. Med., 111, 160
Leach, W. D., Lee, A. and Stubbs, R. P. (1973). Localization of bacteria in the gastrointestinal tract: a possible explanation of intestinal spirochaetosis. Infect. Immun., 7, 961
Robertson, P. W. and Cooper, G. N. (1972). Immune responses in intestinal tissues to particulate antigens. Plaque-forming and rosette-forming responses in rats. Aust. J. Exp. Biol. Med. Sci., 50, 703
Robertson, P. W. and Cooper, G. N. (1973). Immune responses in intestinal tissues to particulate antigens. Development of cells forming different classes of antibody in primary and secondary responses. Aust. J. Exp. Biol. Med. Sci., 51, 575
Springer, G. F., Honton, R. E. and Forbes, M. (1959). Origin of anti-human blood group B agglutinins in germ-free chicks. Ann. N.Y. Acad. Sci., 78, 272
Tlaskalova, H., Kamarytova, V., Mandel L. et al. (1972). Folio Biologica, xvi, 177
Triger, D. R., Alp, M. H. and Wright, R. (1972). Bacterial and dietary anitibpdies in liver disease. Lancet, i, 60
Tyler, P. A. and Marshall, K. C. (1967). Pheomorphy in stalked, budding bacteria. J. Bact., 93, 1132
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 MTP Press Limited
About this chapter
Cite this chapter
Lee, A., Foo, M.C. (1978). Natural antibodies and the intestinal flora in rodents. In: Hemmings, W.A. (eds) Antigen Absorption by the Gut. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6609-6_13
Download citation
DOI: https://doi.org/10.1007/978-94-011-6609-6_13
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-6611-9
Online ISBN: 978-94-011-6609-6
eBook Packages: Springer Book Archive