Abstract
It is almost normal practice to greet a newly described biological phenomenon by naming a substance by which one hopes it is mediated. Even if the phenomenon has been correctly described a simple mediator may not account for it; if incompletely or incorrectly described, search for a simple mediator is at best a hazard. Mediation may be by an array of components, e.g. like a chain of enzymes. Complexity mounts as we delve deeper into biological phenomena and their inter-relationships; there are the multiple components of complement, of coding, of capping, of clotting.
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References
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Davies, D.A.L. (1973). Chemistry of HL-A Antigen: Separation, Assay and Biological Properties. In: Calne, R.Y. (eds) Immunological Aspects of Transplantation Surgery. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6600-3_4
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