Skip to main content

Chemistry of HL-A Antigen: Separation, Assay and Biological Properties

  • Chapter
Immunological Aspects of Transplantation Surgery
  • 49 Accesses

Abstract

It is almost normal practice to greet a newly described biological phenomenon by naming a substance by which one hopes it is mediated. Even if the phenomenon has been correctly described a simple mediator may not account for it; if incompletely or incorrectly described, search for a simple mediator is at best a hazard. Mediation may be by an array of components, e.g. like a chain of enzymes. Complexity mounts as we delve deeper into biological phenomena and their inter-relationships; there are the multiple components of complement, of coding, of capping, of clotting.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Albert, W. H. W. and Davies, D. A. L. (1973). H-2 antigens on nuclear membranes. Immunology, 24, 1

    Google Scholar 

  • Allan, D. and Crumpton, M. J. (1971). Solubilization of pig lymphocyte plasma membrane and fractionation of some of the components. Biochem. J., 123, 967

    PubMed  CAS  Google Scholar 

  • Amos, D. B., Seigler, H. F., Southworth, J. G. and Ward, F. E. (1969). Skin graft rejection between subjects genotyped for HL-A. Transplant. Proc., 1, 342

    PubMed  CAS  Google Scholar 

  • Amos, D. B. and Yunis, E. J. (1971). A new interpretation of the major histocompatibility gene complexes of man and mouse. Cell. Immunol., 2, 517

    Article  PubMed  CAS  Google Scholar 

  • Bailey, D. W. (1963). Histoincompatibility associated with the X chromosome in mice. Transplantation, 1, 70

    Article  PubMed  CAS  Google Scholar 

  • Baldwin, R. W. and Glaves, D. (1972). Solubilization of tumor-specific antigen from plasma membrane of an aminoazo-dye-induced rat hepatoma. Clin. Exp. Immunol., 11, 51

    PubMed  CAS  Google Scholar 

  • Balner, H., Gabb, B. W., Dersjant, H., Van Vreeswijk, W. and Van Rood, J. J. (1971). Major histocompatibility locus of rhesus monkeys (RhL-A). Nature New Biol., 230, 177

    Article  PubMed  Google Scholar 

  • Barnes, A. D. (1964). A quantitative comparison study of immunizing ability of different tissues. Ann. N.Y. Acad. Sci., 120, 237

    Article  PubMed  CAS  Google Scholar 

  • Barnes, A. D. and Hawker, R.J. (1972). Leukocyte antigens in baboons: a preliminary to tissue typing for organ grafting. Transplant. Proc., 4, 37

    PubMed  CAS  Google Scholar 

  • Batchelor, J. R., Shumak, K. H. and Watts, H. G. (1973).125í-labeled rat transplantation alloantibody. Transplantation, 15, 80

    Google Scholar 

  • Belpomme, D., Le Borgne de Kaouel, C., Ajuria, E., Jasmin, C. and Dore, J. F. (1969). Increase in antigenicity of permanent tissue culture lines ICI 101, ICI 104 and ICI 202 established from human leukemic blood. Nature (London), 222, 890

    Google Scholar 

  • Bennett, D., Boyse, E. A. and Old, L. J. (1972). Cell surface immunogenetics in the study of morphogenesis. In Cell Interactions, Third Lepetit Colloquium, p. 247 ( L. G. Silvestri, editor). Amsterdam: North Holland )

    Google Scholar 

  • Billingham, R. E., Brent, L. and Medawar, P. B. (1956). The antigenic stimulus in transplantation immunity. Nature (London), 178, 514

    Article  CAS  Google Scholar 

  • Billingham, R. E., Brent, L. and Medawar, P. B. (1958). Extraction of antigens causing transplantation immunity. Transplant. Bull., 5, 377

    Article  PubMed  CAS  Google Scholar 

  • Bjaring, B. and Klein, G. (1968). Antigenic characterization of heterozygous mouse lymphomas after immunoselection in vivo. J. Nat. Cancer Inst., 41, 1411

    CAS  Google Scholar 

  • Boyse, E. A., Miyazawa, M., Aoki, T. and Old, L. J. (1968a). Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc. Roy. Soc. (London) B, 170, 175

    Article  CAS  Google Scholar 

  • Boyse, E. A., Old, L. J. and Stockert, E. (1968b). An approach to the mapping of antigens on the cell surface. Proc. Nat. Acad. Sci. USA., 60, 886

    Article  PubMed  CAS  Google Scholar 

  • Boyse, E. A., Stockert, E. and Old, L. J. (1968c). Properties of four antigens specified by the Tla locus. Similarities and differences. In International Convocation on Immunology, p. 353 ( N. R. Rose and F. Milgrom, editors). Basel: S. Karger

    Google Scholar 

  • Boyse, E. A., Flaherty, L., Stockert, E. and Old, L. J. (1970). Histoincompatibility attributable to genes near H-2 that are not revealed by hemagglutination or cytotoxicity tests. Transplantation, 13, 431

    Article  Google Scholar 

  • Boyse, E. A., Itakura, K., Stockert, E., Iritani, C. A. and Miura, M. (1971). Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes. Transplantation, 11, 351

    Article  PubMed  CAS  Google Scholar 

  • Brent, L., Hansen, J. A., Kilshaw, P. J. and Thomas, A. V. (1973). Specific unresponsiveness to skin allografts in mice. I. Properties of tissue extracts and their synergistic effect with antilymphocyte serum. Transplantation, 15, 160

    Article  PubMed  CAS  Google Scholar 

  • Charlton, R. K. and Zmijewski, C. M. (1970). Soluble HL-A7 antigen: localization in the ß-lipoprotein fraction of human serum. Science, 170, 636

    Article  PubMed  CAS  Google Scholar 

  • Chen, L. and Watkins, J. F. (1970). Evidence against the presence of H-2 histocom- patibility antigens in Ehrlich ascites tumour cells. Nature (London), 225, 734

    Article  CAS  Google Scholar 

  • Cikes, M. (1970). Relationship between growth rate, cell volume, cell cycle kinetics, and antigenic properties of cultured murine lymphoma cells. J. Nat. Cancer Inst., 45, 979

    PubMed  CAS  Google Scholar 

  • Colombani, J., Colombani, M., Viza, D. C., Degani, Bernard, O., Dausset, J. and Davies, D. A. L. (1970). Separation of HL-A transplantation antigen specificities. Transplantation, 9, 228

    CAS  Google Scholar 

  • Cullen, S. E. and Nathenson, S. G. (1971). Distribution of H-2 alloantigenic specificities on radiolabelled papain-solubilized antigen fragments. J. Immunol., 107, 563

    PubMed  CAS  Google Scholar 

  • Cullen, S. E., Schwartz, B. D., Nathenson, S. G. and Cherry, M. (1972). The molecular basis of codominant expression of the histocompatibility-2 genetic region. Proc. Nat. Acad. Sci. USA., 69, 1394

    Article  PubMed  CAS  Google Scholar 

  • Dausset, J. D. and Rapaport, F. T. (1966). The role of blood group antigens in human histocompatibility. Ann. N.Y. Acad. Sci., 129, 408

    Article  Google Scholar 

  • Davies, D. A. L. (1963). The presence of non-H-2 histocompatibility specificities in preparations of mouse H-2 antigens. Transplantation, 1, 562

    Article  PubMed  CAS  Google Scholar 

  • Davies, D. A. L. (1966). Mouse histocompatibility isoantigens derived from normal and from tumor cells. Immunology, 11, 115

    PubMed  CAS  Google Scholar 

  • Davies, D. A. L. (1967). Soluble H-2 isoantigens. Transplantation, 5, 31

    Article  CAS  Google Scholar 

  • Davies, D. A. L. (1968). Transplantation Antigens. Chapter 38 in Human Transplantation (F. T. Rapaport and J. Dausset, editors). New York: Grune and Stratton

    Google Scholar 

  • Davies, D. A. L. (1969). The molecular individuality of different mouse H-2 histo-compatibility specificities determined by single genotypes. Transplantation, 8, 51

    Article  PubMed  CAS  Google Scholar 

  • Davies, D. A. L. (1970). Transplantation antigens: some features of mouse H-2 molecules and their relevance to HL-A in man. In Blood and Tissue Antigens, p. 101 ( D. Aminofl, editor). New York: Academic Press

    Google Scholar 

  • Davies, D. A. L. (1973). Preparation of antigens from tissues and fluids. Chapter 11 in Handbook of Experimental Immunology, 2nd Ed. ( D. M. Weir, editor). Oxford: Blackwell Scientific Publications

    Google Scholar 

  • Davies, D. A. L. and Hutchison, A. M. (1961). The serological determination of histocompatibility activity. Brit. J. Exp. Pathol., 42, 587

    CAS  Google Scholar 

  • Davies, D. A. L., Alkins, B. J., Boyse, E. A., Old, L. J. and Stockert, E. (1969). Soluble TL and H-2 antigens prepared from a TL positive leukaemia of a TL negative mouse strain. Immunology, 16, 669

    PubMed  CAS  Google Scholar 

  • Davies, D. A. L., Boyse, E. A., Old, L. J. and Stockert, E. (1967). Mouse isoantigens: separation of soluble TL (thymus-leukaemia) antigen from soluble H-2 histocompatibility antigen by column chromatography. J. Exp. Med., 125, 549

    Article  PubMed  CAS  Google Scholar 

  • Davies, D. A. L., Manstone, A. J., Viza, S. C., Colombani, J. and Dausset, J. (1968). Human transplantation antigens: the HL-A (Hu-1) system and its homology with the mouse H-2 system. Transplantation, 6, 571

    Article  PubMed  CAS  Google Scholar 

  • Davies, D. A. L., Colombani, J., Viza, D. C. and Hämmerling, U. (1971a). Extraction of HL-A transplantation antigen in high molecular weight soluble form. Clin. Exp. Immunol., 8, 801

    Google Scholar 

  • Davies, D. A. L., Hämmerling, U. and Alkins, B. J. (197lb). Transplantation antigens in a high molecular form. H. Non H-2 mouse antigens and membrane structure. Immunochemistry, 8, 17

    Google Scholar 

  • Dersjant, H., Van Vreeswijk, W. and Balner, H. (1973). Relation between chimpanzee leukocyte antigens and HL-A. In Immunobiological Standardization Symposia series No. 18, p. 61 ( R. H. Regamey and J. V. Spärck, editors). Basel: S. Karger

    Google Scholar 

  • Dick, H. M., Steel, C. M. and Crichton, W. B. (1972). HL-A typing of cultured peripheral lymphoblastoid cells. Tissue Antigens, 2, 85

    Article  PubMed  CAS  Google Scholar 

  • Downing, H. J., Brain, P., Hammond, M. G., Vos, G. H. and Webb, G. R. (1972). Leukocyte antigens of baboons. Transplant. Proc., 4, 33

    PubMed  CAS  Google Scholar 

  • Edidin, M. (1967). Preparation of single soluble antigens of the mouse histocompatibility-2 complex. Proc. Nat. Acad. Sci. USA., 57, 1226

    Article  PubMed  CAS  Google Scholar 

  • Fellous, M. and Dausset, J. (1970). Probable haploid expression of HL-A antigens on human spermatozoon. Nature (London), 225, 191

    Article  CAS  Google Scholar 

  • Festenstein, H., Abbafi, K., Sachs, J. A. and Oliver, R. T. D. (1972). Serologically undetectable immune responses in transplantation. Transplant. Proc., 4, 219

    Google Scholar 

  • Friedman, E. A. and Valenti, C. (1966). Persistence of individual specific transplantation antigens in long term cultures of rabbit skin. Transplantation, 4, 747

    Article  PubMed  CAS  Google Scholar 

  • Gangal, S. G., Merchant, D. J. and Shreffler, D. C. (1966). Characterization of the H-2 antigens of L-M mouse cells grown in culture. J. Nat. Cancer Inst., 36, 1151

    PubMed  CAS  Google Scholar 

  • Gleason, R. E. and Fanguy, R. C. (1964). The relationship of blood groups to skin graft survival in chickens. Transplantation, 2, 509

    Article  PubMed  CAS  Google Scholar 

  • Gluecksohn-Waelsch, S. and Erickson, R. P. (1970). The T-locus of the mouse: implications for mechanisms of development. Curr. Top. Den. Biol., 5, 281

    Article  CAS  Google Scholar 

  • Goldberg, E. H., Aoki, T., Boyse, E. A. and Bennett, D. (1970). Detection of H-2 antigens on mouse spermatozoa by the cytotoxicity test. Nature (London), 228, 570

    Article  CAS  Google Scholar 

  • Goldberg, E. H., Boyse, E. A., Bennett, D., Scheid, M. and Carswell, E. A. (1971). Serological demonstration of H-Y (Male) antigen on mouse sperm. Nature (London), 232, 478

    Article  CAS  Google Scholar 

  • Graff, R. J. (1970). Polymorphism of histocompatibility genes in the mouse. Transplant. Proc., 2, 15

    PubMed  CAS  Google Scholar 

  • Graff, R. J. and Nathenson, S. G. (1971) Immunogenic properties of papain-solubilized alloantigen. Transplant. Proc., 3, 249

    PubMed  CAS  Google Scholar 

  • Halle-Pannenko, O., Martyré, M. C. and Jolles, P. (1971a). Conditioning of allogeneic mice with crude and purified H-2 extracts, alone and combined with cyclophosphamide, for skin graft prolongation. Transplant. Proc., 3, 257

    PubMed  CAS  Google Scholar 

  • Halle-Pannenko, O., Martyré, M. C. and Mathé, G. (197 lb). Prevention of graftversus-host reaction by donor pretreatment with soluble H-2 antigen. Transplantation, 11, 414

    Google Scholar 

  • Hämmerling, U., Davies, D. A. L. and Manstone, A. J. (1971). Transplantation antigens in a high molecular weight form. I. Mouse H-2 antigens. Immunochemistry, 8, 7

    Article  PubMed  Google Scholar 

  • Harris, R. and Zervas, Z. D. (1969). Reticulocyte HL-A antigens. Nature (London), 221, 1062

    Article  CAS  Google Scholar 

  • Harris, T. N., Harris, S. and Ogburn, C. A. (1971). Solubilization of H-2 histocompatibility antigens of the mouse by Triton X100 and Butanol. Transplantation, 12, 448;

    Article  PubMed  CAS  Google Scholar 

  • Harris, T. N., Harris, S., Ogburn, C. A., Bocchieri, M. H. and Farber, M. B. (1971). Accelerated rejection of allogeneic skin grafts in the mouse after injections of histocompatibility antigens solubilized by Triton, Butanol, and Papain. Transplantation, 12, 459

    Article  PubMed  CAS  Google Scholar 

  • Hayman, M. J. and Crumpton, M. J. (1972). Isolation of glycoproteins from pig lymphocyte plasma membrane using Lens culinaris phytohemagglutinin. Biochem Biophys. Res. Commun., 47, 923

    Article  PubMed  CAS  Google Scholar 

  • Hess, M. and Davies, D. A. L. (1973). Structure of histocompatibility antigens. On the reduction and alkylation of mouse histocompatibility antigens. Eur. J. Biochem.

    Google Scholar 

  • Heslop, B. F. (1973). The male antigen in the rat. Transplantation, 15, 31

    Article  PubMed  CAS  Google Scholar 

  • Hirata, A. A. and Terasaki, P. I. (1970). Cross-reactions between streptococcal M proteins and human transplantation antigens. Science, 168, 1095

    Article  PubMed  CAS  Google Scholar 

  • Hughes, R. C. (1973). Glycoproteins as components of cellular membranes. In Progress in Biophysics and Molecular Biology, p. 191 ( J. A. V. Butler and L. Noble, editors). Oxford: Pergamon Press

    Google Scholar 

  • Ivaskova, E., Dausset, J. and Ivânyi, P. (1972). Cytotoxic reactions of anti-H-2 sera with human lymphocytes. Folia Biol. (Prague), 18, 194

    CAS  Google Scholar 

  • Judd, K. P. and Trentin, J. J. (1972). Tolerance induction to murine cardiac allografts with anti-thymocyte globulin (ATG) and cell flee antigens. Transplantation Abstracts of the Fourth International Congress of the Transplantation Society, p. 154 ( S. L. Kountz, editor). New York: Grune and Stratton

    Google Scholar 

  • Kandutsch, A. A. (1960). Intracellular distribution and extraction of tumour homograftenhancing antigens. Cancer Res., 20, 264

    PubMed  CAS  Google Scholar 

  • Kandutsch, A. A. and Stimpfling, J H (1963). Partial purification of tissue isoantigens from a mouse sarcoma. Transplantation, 1, 201

    Article  Google Scholar 

  • Kerman, R. H., Harris, T. N. and Harris, S. (1972). Preparation of dialyzable histocompatibility antigen from Balb/c mice. Proc. Nat. Acad. Sci. USA., 69, 223

    Article  PubMed  CAS  Google Scholar 

  • Kilshaw, P. J., Brent, L. and Thomas, A. V. (1973). Transplantation (In press)

    Google Scholar 

  • Klein, D., Merchant, D. J., Klein, J. and Shrefer, D. C. (1970). Persistence of H-2 and some non-H-2 antigens on long-term-cultured mouse cell lines. J. Nat. Cancer Inst., 44, 1149

    PubMed  CAS  Google Scholar 

  • Klein, J. and Shreffler, D. C. (1971). The H-2 model for the major histocompatibility systems. Transplant. Rev., 6, 3

    PubMed  CAS  Google Scholar 

  • Lalezari, P., Thalenfeld, B. and Weinstein, W. J. (1970). The third neutrophil antigen. In Histocompatibility Testing, p. 319 ( P. I. Terasaki, editor). Copenhagen: Munksgaard

    Google Scholar 

  • Law, L. W., Appella, E., Strober, S., Wright, P. W. and Fischetti, T. (1972). Induction of immunological tolerance to soluble histocompatibility-2 antigens of mice. Proc. Nat. Acad. Sci. USA., 69, 1858

    Article  PubMed  CAS  Google Scholar 

  • Legrand, L. and Dausset, J. (1971). Cell surface interaction between HL-A antigen determinants. Nature New Biol., 234, 271

    PubMed  CAS  Google Scholar 

  • Lilly, F. and Nathenson, S. G. (1968). Solubilization of the H-6A isoantigen of the mouse. In Advance in Transplantation, p. 279 (J. Dausset, J. Hamburger, and G. Math6, editors). Copenhagen: Munksgaard

    Google Scholar 

  • Loke, Y. W., Joysey, V. C. and Borland, R. (1971). HL-A antigens on human trophoblast cells. Nature (London), 232, 403

    Article  CAS  Google Scholar 

  • MacDonald, A. S., Davies, D. A. L., and Calne, R. Y. (1972). Factors governing antigen and antibody enhancement of the rat heart allografts. Transplantation Abstracts of the Fourth International Congress of the Transplantation Society, p. 180 ( S. L. Kountz, editor). New York: Grune and Stratton

    Google Scholar 

  • McDonald, J. C., Jacobbi, L. and Williams, R. W. (1970). HL-A antigen studies with leukocyte cell lines. Transplantation, 10, 499

    Article  PubMed  CAS  Google Scholar 

  • McDevitt, H. O., Deak, B. D., Shreffler, D. C., Klein, J., Stimpfling, J. H. and Snell, G. D. (1972). Genetic control of the immune response: mapping of the IR-1 locus. J. Exp. Med.,135. 1259

    Google Scholar 

  • McPherson, J. C., Clamp, J. R. and Manstone, A. J. (1971). Carbohydrate analysis of membrane derived glycoproteins carrying some cell surface expressed antigens. Immunochemistry, 8, 225

    Google Scholar 

  • Malchow, D., Droege, W. and Strominger, J. L. (1972). Solubilization and partial purification of lymphocyte specific antigens in the chicken. Eur. J. Immunol., 2, 30

    Google Scholar 

  • Mandel, M. A., Monaco, A. P. and Russell, P. S. (1965). Destruction of splenic transplantation antigens by a factor present in liver. J. Immunol., 95, 673

    PubMed  CAS  Google Scholar 

  • Mann, D. L. (1972). The effect of enzyme inhibitor on the solubilization of HL-A antigens with 3M KC1. Transplantation, 14, 398

    Article  PubMed  CAS  Google Scholar 

  • Mann, D. L. and Nathenson, S. G. (1969). Comparison of soluble human and mouse transplantation antigens. Biochemistry, 64, 1380

    CAS  Google Scholar 

  • Mann, D. L., Rogentine, G. N., Fahey, J. L. and Nathenson, S. G. (1969). Hunan lymphocyte membrane (HL-A) alloantigens: isolation, purification and properties. J. Immunol., 103, 282

    PubMed  CAS  Google Scholar 

  • Manson, L. A. and Palm, J. (1966). Mouse transplantation antigens: blocking by liver and kidney microsomal lipoproteins of homograft immunity induced by H-2 transplantation antigens. IXth Internat. Congress of Microbiology, Moscow. Abstracts, p. 642

    Google Scholar 

  • Miyakawa, Y., Tanigaki, N., Yagi, Y. and Pressman, D. (1971). Human transplantation antigens: isolation and radioimmunoassay. Proc. Soc. Exp. Biol. Med., 136, 899

    PubMed  CAS  Google Scholar 

  • Miyakawa, Y., Tanigaki, N., Yagi, Y. and Pressman, D. (1973). Common antigenic structures of HL-A antigens. I. Antigenic determinants recognizable by rabbits on papain-solubilized FIL-A molecular fragments. Immunology, 24, 67

    PubMed  CAS  Google Scholar 

  • Muranaatsu, T. and Nathenson, S. G. (1970). Studies on the carbohydrate portion of membrane-located mouse H-2 alloantigens. Biochemistry, 9, 4875

    Article  Google Scholar 

  • Nathenson, S. G. (1970). Biochemical properties of histocompatibility antigens. Ann. Rev. Genet., 4, 69

    Article  PubMed  CAS  Google Scholar 

  • Nathenson, S. G. and Davies, D. A. L. (1966a). Solubilization and partial purification of mouse histocompatibility antigens from a membranous lipoprotein fraction. Proc. Nat. Acad. Sci. USA., 56, 476

    Article  PubMed  CAS  Google Scholar 

  • Nathenson, S. G. and Davies, D. A. L. (1966b). Transplantation antigens: studies of the mouse model system, solubilization and partial purification of H-2 isoantigens. Ann. N.Y. Acad. Sci., 129, 6

    Article  CAS  Google Scholar 

  • Nathenson, S. G. and Muramatsu, T. (1971). Properties of the carbohydrate portion of mouse H-2 alloantigen glycoproteins. In Glycoproteins of blood cells and plasma, p. 245 ( G. A. Jamieson, editor). Philadelphia: J. B. Lippincott Co.

    Google Scholar 

  • Nathenson, S. G., Schwartz, B. D. and Cullen, S. E. (1972) Immunochemical properties and genetic relationships of H-2 histocompatibility alloantigens. In Membrane and Viruses in Immunopathology, p. 117 ( S. C. Day and R. A. Good, editors). New York: Academic Press

    Google Scholar 

  • Nathenson, S. G., Shimada, A., Yamane, K., Muramatsu, T., Cullen, S. E., Mann, D. L., Fahey, J. L. and Graff, R. (1970). Biochemical properties of papainsolubilized murine and human histocompatibility alloantigens. Fed. Proc., 29, 2026

    PubMed  CAS  Google Scholar 

  • Neauport-Sautes, C., Silvestre, D., Niccolai, M. G., Kourilsky, F. M. and Levy, J. P. (1972). Ultrastructural localization of human HL-A membrane antigens by use of hybrid antibodies. Immunology, 22, 833

    PubMed  CAS  Google Scholar 

  • O’Neill, G. J. and Davies, D. A. L. (1971). Behaviour of mouse H-2 specificities on polyacrylamide gel electrophoresis and polyacrylamide gel electrofocussing. Biochim. Biophys. Acta, 243, 337

    PubMed  Google Scholar 

  • Pasternak, C. A., Warmsley, A. M. H. and Thomas, D. B. (1971). Structural alterations in the surface membrane during the cell cycle. J. Cell Biol., 50, 562

    Article  PubMed  CAS  Google Scholar 

  • Reif, A. E. and Allen, J. M. V. (1964). The AKR thymic antigen and its distribution in leukaemias and nervous tissues. J. Exp. Med., 120, 413

    Article  PubMed  CAS  Google Scholar 

  • Reisfeld, R. A. and Kahan, B. D. (1971). Extraction and purification of soluble histocompatibility antigens. Transplant. Rev., 6, 81

    PubMed  CAS  Google Scholar 

  • Reisfeld, R. A., Pellegrino, M., Papermaster, B. W. and Kahan, B. D. (1970). HL-A antigens from a continuous lymphoid cell line derived from a normal donor J. Immunol., 104, 560

    PubMed  CAS  Google Scholar 

  • Rosenberg, E. B., Mann, D. L., Hill, J. J. and Fahey, J. L. (1971). Prolonged skin allo-graft survival in mice pretreated with soluble transplantation antigens. Transplantation, 12, 402

    Article  PubMed  CAS  Google Scholar 

  • Sanderson, A. R. (1965). Cytotoxic reactions of mouse isoantisera: the scope of an assay using radiolabelled target cells. Transplantation, 3, 557

    Article  PubMed  CAS  Google Scholar 

  • Sanderson, A. R., Cresswell, P. and Welsh, K. I. (1971). Involvement of carbohydrate in the immunochemical determinant area of HL-A substances. Nature New Biol., 230, 8

    Article  PubMed  CAS  Google Scholar 

  • Sanderson, A. R. and Welsh, K. (1973). Quantitation of transplantation (HL-A) antigen sites on peripheral human lymphocytes. Biochem. Soc. Trans. (In press)

    Google Scholar 

  • Sanford, B. H. and Codington, J. F. (1971). Further studies on the effect of neuraminidase on tumour cell transplantability. Tissue Antigens, 1, 153

    Article  PubMed  CAS  Google Scholar 

  • Sasportes, M., Dehay, C. and Fellous, M. (1971). Variations of the expression of HL-A antigens on human diploid fibroblasts in vitro. Nature (London), 233, 332

    Article  CAS  Google Scholar 

  • Scheid, M., Boyse, E. A., Carswell, E. A. and Old, L. J. (1972). Serologically demonstrable alloantigens of mouse epidermal cells. J. Exp. Med., 135, 938

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, B. D. and Nathenson, S. G. (1971a). Isolation of H-2 alloantigens solubilized by the detergent NP-40. J. Immunol., 107, 1363

    PubMed  CAS  Google Scholar 

  • Schwartz, B. D. and Nathenson, S. G. (1971b). Regeneration of transplantation antigens on mouse cells. Transplant. Proc., 3, 180

    PubMed  CAS  Google Scholar 

  • Seigler, H. F., Kremer, W. B., Metzgar, R. S., Ward, F. E., Haung, A. T. and Amos, D. B. (1971). HL-A antigenic loss in malignant transformation. J. Nat. Cancer Inst., 46, 577

    PubMed  CAS  Google Scholar 

  • Shitnada, A. and Nathenson, S. G. (1969). Murine histocompatibility-2 (H-2) allo-antigens. Purification and some chemical properties of soluble products from H-2b and H-2d genotypes released by papain digestion of membrane fractions. Biochemistry, 8, 4048

    Article  Google Scholar 

  • Singal, D. P., Berry, R. and Naipaul, N. (1971). HL-A inhibiting activity in human seminal plasma. Nature New Biol., 233, 61

    Article  PubMed  CAS  Google Scholar 

  • Staines, N. A., O’Neill, G. J., Guy, K. and Davies, D. A. L. (1973). Xenoantisera against lymphoid cells: specificity and use in monitoring purification of mouse and human histocompatibility antigens. Tissue Antigens, 3, 1

    Article  PubMed  CAS  Google Scholar 

  • Stuart, F. P., Fitch, F. W. and Rowley, D. A. (1970). Specific suppression of renal allograft rejection by treatment with antigen and antibody. Transplant. Proc., 2, 483

    PubMed  CAS  Google Scholar 

  • Sumerska, T., Betel, I. and Balner, H. (1971). Skin graft prolongation in rats using ALS and soluble histocompatibility antigens. Radiobiological Institute TNO, Annual Report, p. 101 ( 151 Lange Kleiweg, Rijswijk, Holland )

    Google Scholar 

  • Summerlin, W. T., Faanes, R. B. and Good, R. A. (1972). Homologous transplantation of cultured skin. Transplantation Abstracts of the Fourth International Congress of the Transplantation Society, p. 280 ( S. L. Kountz, editor). New York: Grune and Stratton

    Google Scholar 

  • Tissot, R. G. and Cohen, C. (1972). Histocompatibility in the rabbit: identification of the major locus. Tissue Antigens, 2, 267

    Article  PubMed  CAS  Google Scholar 

  • Turner, M. J., Strominger, J. L. and Sanderson, A. R. (1972). Enzymic removal and re-expression of a histocompatibility antigen, HL-A 2, at the surface of human peripheral lymphocytes. Proc. Nat. Acad. Sci. USA., 69, 200

    Article  PubMed  CAS  Google Scholar 

  • Vaiman, M., Gamier, H., Kunlin, A., Hay, J. M., Parc, R., Bacour, F., Fagniez, P. H., Villiers, P. A., Lecointre, J., Bara, M. F. and Nizza, P. (1972). The SL-A histocompatibility system in the Sus scrofa species. Transplantation, 14, 541

    Article  PubMed  CAS  Google Scholar 

  • Van Rood, J. J., Van Leeuwen, A. and Van Santen, M. C. T. (1970). Anti HL-A2 inhibitor in normal human serum. Nature (London), 226, 366

    Article  Google Scholar 

  • Viza, D. C., Degani, O., Dausset, J. and Davies, D. A. L. (1968). Lymphocyte stimulation by soluble human HL-A transplantation antigens. Nature (London), 219, 704

    Article  CAS  Google Scholar 

  • Viza, D., Sugar, J. R. and Binns, R. M. (1970). Lymphocyte stimulation in pigs: evidence for the existence of a single major histocompatibility locus, PL-A. Nature (London), 227, 949

    Article  CAS  Google Scholar 

  • Vojtískova, M. and Pokornâ, Z. (1971). Developmental expression of H-2 antigens in the spermatogenic cell series: possible bearing on haploid gene action. Folio Biol. (Prague), 18, 1

    Google Scholar 

  • Westbroek, D. L., Silberbusch, J., Vriesendorp, H. M., Van Urk, H., Roemeling, H. W., Schönherr-Scholtes, Y. and de Vries, M. J. (1972). The influence of DL-A histocompatibility on the function and pathohistological changes in unmodified canine renal allografts. Transplantation, 14, 582

    CAS  Google Scholar 

  • Wigzell, H. (1965). Quantitative titration, kinetic behaviour and inhibition of cytotoxic mouse isoantisera. Immunology, 9, 287

    Google Scholar 

  • Yamane, K. and Nathenson, S. G. (1970). Murine histocompatibility-2 (H-2) allo-antigens: purification and some chemical properties of a second class of fragments (Class II) solubilized by papain from cell membranes of H-2b and H-2d mice. Biochemistry, 9, 1336

    Article  PubMed  CAS  Google Scholar 

  • Yamane, K.. Shimada, A. and Nathenson, S. G. (1972). Peptide comparison of two histocompatibility-2 (H-2b and H-2d) alloantigens. Biochemistry,11. 2398

    Google Scholar 

  • Yunis, E. J. and Amos, D. B. (1971). Three closely linked genetic systems relevant to transplantation. Proc. Nat. Acad. Sci. USA., 68, 3031

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1973 Roy Y. Calne

About this chapter

Cite this chapter

Davies, D.A.L. (1973). Chemistry of HL-A Antigen: Separation, Assay and Biological Properties. In: Calne, R.Y. (eds) Immunological Aspects of Transplantation Surgery. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6600-3_4

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-6600-3_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6602-7

  • Online ISBN: 978-94-011-6600-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics