Abstract
Although the pathogenesis of multiple sclerosis (MS) is unknown, much evidence suggests that MS is an immunologically mediated disorder in which demyelinating factors have been detected in serum and in cerebrospinal fluid (CSF)1–4. In MS sera ‘blocking factors’, possibly auto-antibodies, have been shown to affect nerve conduction in vitro 5. Unconcentrated CSF from MS patients in acute relapse can produce demyelination of tadpole optic nerves6. Moreover, circulating immune complexes have been described in MS7,8. Preliminary reports indicated a possible benefit from plasma exchanges (PE) in MS patients9,10. In order to study the effect of PE in CSF and serum IgG, we studied 18 MS patients, treated with a cycle of PE.
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© 1984 MTP Press Limited
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Capparelli, R. et al. (1984). Plasmapheresis in multiple sclerosis: cerebrospinal fluid changes after treatment. In: Gonsette, R.E., Delmotte, P. (eds) Immunological and Clinical Aspects of Multiple Sclerosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6352-1_31
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DOI: https://doi.org/10.1007/978-94-011-6352-1_31
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-6354-5
Online ISBN: 978-94-011-6352-1
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