Abstract
For optimal treatment of bacterial meningitis, it is desirable that the antibiotic chosen be bactericidal and able to achieve CSF levels in excess of the minimum bactericidal concentration for the causative organism. Combination of antimicrobials are avoided that might be antagonistic to one another relative to the organism that is isolated. For example, chlor-amphenicol antagonizes the bactericidal action of penicillin or ampicillin against Streptococcus pneumoniae and Group B Streptococcus. Chlor-amphenicol also interferes with the bactericidal action of gentamicin against certain Gram-negative enteric rods.
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Bell, W.E. (1984). Treatment of Bacterial Infections of The Central Nervous System. In: Thompson, R.A., Green, J.R. (eds) Infectious Diseases of the Central Nervous System. Neurologic Illness. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6332-3_7
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DOI: https://doi.org/10.1007/978-94-011-6332-3_7
Publisher Name: Springer, Dordrecht
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