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Infectious Diseases of the Central Nervous System pp 19–45Cite as

Slow Virus Infection by Conventional Virus Agents

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Part of the book series: Neurologic Illness ((Ni))

Abstract

Eight years have elapsed since the First Annual Symposium of the Barrow Neurologic Institute. Several sessions at that symposium, which was also devoted to infectious diseases of the central nervous system, concerned slow viral infections of the central nervous system (CNS). Detailed attention was given to three major diseases of human and veterinary medicine caused by conventional viral agents: visna, subacute sclerosing panencephalitis, and progressive multifocal leukoencephalopathy. Since that symposium several additional subacute or chronic viral infections of the human CNS have been delineated and considerable progress has been made toward a more molecular understanding of the mechanisms which underlie some of these disorders. In this chapter we consider only those diseases which are caused by conventional viruses; that is, infectious agents whose genomes consist of nucleic acids which are replicated intracellularly utilizing host cellular synthetic machinery and which direct the synthesis of proteins necessary for their continued efficient transfer to other uninfected cells or hosts. Such a definition would exclude from consideration viriods, infectious agents of plants with very small ribonucleic acids (RNA) which lack any associated protein, and the physicochemically incompletely defined transmissible agents of the subacute spongiform encephalopathies of animals (scrapie) and man (kuru, Creutzfeldt-Jakob disease).5 The latter agents, recently refered to as prions, are discussed in detail in the next chapter.

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  1. Jerry S. Wolinsky
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Editors and Affiliations

  1. Division of Neurology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona, USA

    Richard A. Thompson M.D.

  2. Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona, USA

    John R. Green M.D., F.A.C.S. (Chairman of Neurosurgery, and Chairman) (Chairman of Neurosurgery, and Chairman)

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Wolinsky, J.S. (1984). Slow Virus Infection by Conventional Virus Agents. In: Thompson, R.A., Green, J.R. (eds) Infectious Diseases of the Central Nervous System. Neurologic Illness. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6332-3_3

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  • DOI: https://doi.org/10.1007/978-94-011-6332-3_3

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