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Multiple Opiate Receptors

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Social and Medical Aspects of Drug Abuse

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Abstract

Opiates, a large class of “morphine-like” drugs, exert a large range of pharmacological effects, in addition to analgesia. The heterogeneity of effects among opiates has been well known for many years. Most notable in this regard are the properties of the mixed agonist-antagonist opiates of the benzomorphan series. These compounds have been of special interest because of the desirability of developing a drug having morphine-like analgesic effects but lacking addictive potential. Cyclazocine, SKF-10,047 (N-allylnor-cyclazocine), and related drugs of the benzomorphan group differ from classical opiates in displaying psychotomimetic effects in humans and unique behavioral effects in animals (Haertzen, 1970; Holtzman, 1979). The syndromes associated with many of the benzomorphans depend dramatically on the species and vary qualitatively with the dose administered. At low doses many of these drugs produce effective analgesia in humans (Lasagna, 1954; Keats, 1964). In addition, they may clinically antagonize the analgesic and respiratory-depressant effects of classical opiates (Harris, 1964), precipitate a withdrawal syndrome in morphine-addicted patients, and prevent development of addiction to morphine (Martin, 1965). At the same time, these opiates may produce physical dependence when administered alone and a characteristic withdrawal syndrome differing from that of morphine upon drug cessation (Martin, 1965).

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Authors
  1. R. Suzanne Zukin
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  2. Stephen R. Zukin
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Editors and Affiliations

  1. Department of Psychiatry, New York University School of Medicine, New York, New York, USA

    George Serban M.D. (Principal Research Investigator and Clinical Associate Professor) (Principal Research Investigator and Clinical Associate Professor)

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© 1984 Spectrum Publications, Inc.

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Zukin, R.S., Zukin, S.R. (1984). Multiple Opiate Receptors. In: Serban, G. (eds) Social and Medical Aspects of Drug Abuse. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6320-0_8

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  • DOI: https://doi.org/10.1007/978-94-011-6320-0_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6322-4

  • Online ISBN: 978-94-011-6320-0

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