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The Chronic Psychiatric Patient in the Community pp 321–381Cite as

Clinical Pharmacology and Side Effects of Antipsychotic and Mood-Stabilizing Drugs used in the Treatment of Psychiatric Patients with Chronic or Recurrent Disorders

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Abstract

The past two decades have produced almost revolutionary changes in the pattern of care of psychiatric patients. Important features of this revolution are a strikingly decreased prevalence of psychiatric hospitalization, the phasing out of many public mental institutions, the early return of psychotic patients to home and work, the development of open psychiatric units in general hospitals and an increased reliance on local community and outpatient treatment facilities, even for patients with severe psychotic illnesses such as schizophrenia and manic or depressive disorders, many of whom are treated effectively by physicians without specialized training in psychiatry. These changes almost certainly are the result of a complex interplay among new forms of medical treatment of psychiatric patients, administrative decisions, social and philosophic changes in medicine, and cultural and historical factors that are still poorly understood (1).

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References

  1. Baldessarini, R. J. Chemotherapy in Psychiatry. Cambridge, Mass.: Harvard University Press, 1977, 201 pp.

    Google Scholar 

  2. Cooper, T. B., Simpson, G. M., and Lee, J. H. Thymoleptic and neuroleptic drug plasma levels in psychiatry: current status. Intl. Rev. Neurobiol. 19: 269–309 (1976).

    Article  CAS  Google Scholar 

  3. Creese, I., Snyder, S. H. A simple and sensitive radioreceptor assay for antischizophrenic drugs in blood. Nature 270: 180–182 (1977).

    Article  PubMed  CAS  Google Scholar 

  4. Davis, J. M. Overview: Maintenance therapy in psychiatry: I. Schizophrenia. Am. J. Psychiatry 132: 1239–1245 (1975).

    Google Scholar 

  5. Hogarty, G., and Ulrich, R. F. Temporal effects of drug and placebo in delaying relapse in schizophrenic outpatients. Arch. Gen. Psychiatry 34: 297–301 (1977).

    Article  PubMed  CAS  Google Scholar 

  6. Baldessarini, R. J. Drugs and the treatment of psychiatric disorders. Chapter 19 in Goodman and Gilman’s The Pharmacological Basis of Therapeutics, Sixth Edition, A. G. Gilman, L. S. Goodman, and A. Gilman (eds.), New York, MacMillan Co., 1980, pp. 391–447.

    Google Scholar 

  7. Baldessarini, R. J., and Tarsy, D. Pathophysiology of tardive dyskinesia. Int. Rev. Neurobiol. 21: 1–45 (1979).

    Article  PubMed  CAS  Google Scholar 

  8. Creese, I., and Snyder, S. H. Behavioral and biochemical properties of the dopamine receptor, in Psychopharmacology: A Generation of Progress, M. A. Lipton, A. DiMascio, and K. F. Killam, eds. New York: Raven Press, 1978, pp. 377–388.

    Google Scholar 

  9. Snyder, S. H., U’Prichard, D. C, and Greenberg, D. A. Neurotransmitter receptor binding in the brain, in Psychopharmacology: A Generation of Progress, M. A. Lipton, A. DiMascio, and K. F. Killam, eds. New York: Raven Press, 1978, pp. 361–370.

    Google Scholar 

  10. Garver, D. L., Davis, J. M., Dekirmenjian, H., Jones, F. D., Casper, R., and Haraszti, J. Pharmacokinetics of red blood cell phenothiazine and clinical effects: acute dystonic reactions. Arch. Gen. Psychiatry 33: 862–866 (1976).

    Article  PubMed  CAS  Google Scholar 

  11. Granacher, R. P., and Baldessarini, R. J.: Physostigmine: its use in acute anticholinergic syndrome with antidepressant and antiparkinson drugs. Arch. Gen. Psychiatry 32: 375–380 (1975).

    Article  PubMed  CAS  Google Scholar 

  12. Snyder, S. H., Greenberg, D., and Yamamura, H. I. Antischizophrenic drugs and brain cholinergic receptors: Affinity for muscarinic sites predicts extrapyramidal effects. Arch. Gen. Psychiatry 31: 58–61 (1974).

    Article  PubMed  CAS  Google Scholar 

  13. Snyder, S. H., and Yamamura, H. Antidepressants and the muscarinic acetylcholine receptor. Arch. Gen. Psychiatry 34: 236–239 (1977).

    Article  PubMed  CAS  Google Scholar 

  14. Baldessarini, R. J., and Tarsy, D. Tardive dyskinesia, in Psychopharmacology: A Generation of Progress, M. A. Lipton, A. De Mascio, and K. F. Killam, eds. New York: Raven Press, 1978, pp. 993–1004.

    Google Scholar 

  15. Jacobson, G., Baldessarini, R. J., and Manschreck, T. Tardive and withdrawal dyskinesia associated with haloperidol. Am. J. Psychiatry 131: 910–913 (1974).

    PubMed  CAS  Google Scholar 

  16. Jus, K., Jus, A., Gautier, J., Villeneuve, A., Pires, P., Pineau, R., and Villeneuve, R. Studies of the actions of certain pharmacological agents on tardive dyskinesia and on the rabbit syndrome. Int. J. Clin. Pharmacol. 9: 138–145 (1974).

    PubMed  CAS  Google Scholar 

  17. Davis, J. M., Bartlett, E., and Termini, B. A. Overdosage of psychotropic drugs: A review. Dis. Nerv. Syst. 29: 157–164 (1968).

    PubMed  CAS  Google Scholar 

  18. Richelson, E., and Divenetz-Romero, S. Blockade of psychotropic drugs of the muscarinic acetylcholine receptor in cultured nerve cells. Biol. Psychiatry 12: 771–785 (1977).

    PubMed  CAS  Google Scholar 

  19. Baldessarini, R. J. Mood drugs. Disease-a-Month 24(2): 1–65 (1977).

    Article  PubMed  CAS  Google Scholar 

  20. Baldessarini, R. J. The basis of amine hypotheses in affective disorders. Arch. Gen. Psychiatry 32: 1087–1093, (1975).

    Article  PubMed  CAS  Google Scholar 

  21. Robinson, D. S., Nies, A., Ravaris, C. L., Ives, J. O., and Bartlett, D. Clinical pharmacology of phenelzine. Arch. Gen. Psychiatry 35: 629–635 (1978).

    Article  PubMed  CAS  Google Scholar 

  22. Baldessarini, R. J., and Lipinski, J. F., Jr. Lithium salts: 1970–1975. Ann. Intern. Med. 83: 527–533 (1975).

    PubMed  CAS  Google Scholar 

  23. Pope, H. G., Jr., and Lipinski, J. F., Jr. Diagnosis in schizophrenia and manic-depressive illness. Arch. Gen. Psych. 35: 811–828 (1978).

    Article  Google Scholar 

  24. Crews, F. T., and Smith, C. B. Presynaptic alpha-receptor subsensitivity after long-term antidepressant treatment. Science 202: 323–324 (1978).

    Article  Google Scholar 

  25. Pert, A., Rosenblatt, J. E., Sivit, C., Pert, C. B., and Bunney, W. B., Jr. Long-term treatment with lithium prevents the development of dopamine receptor supersensitivity. Science 201: 171–173 (1978).

    Article  PubMed  CAS  Google Scholar 

  26. Appleton, W. S., and Davis, J. M. Practical Clinical Psychopharmacology. Second Edition, Baltimore: Williams and Wilkins, 1980, 173 pp.

    Google Scholar 

  27. Morris, J. B., and Beck, A. T. The efficacy of antidepressant drugs. Arch. Gen. Psychiatry 30: 667–674 (1974).

    Article  PubMed  CAS  Google Scholar 

  28. Blackwell, B., Stefopoulos, A., Enders, P., Kuzma, R., and Adolphe, A. Anticholinergic activity of two tricyclic antidepressants. Am. J. Psychiatry 135: 722–724 (1978).

    PubMed  CAS  Google Scholar 

  29. Davis, J. M. Overview: Maintenance therapy in psychiatry. II. Affective disorders, Am. J. Psychiatry 133: 1–13 (1976).

    PubMed  CAS  Google Scholar 

  30. Atkinson, R. M., and Ditman, K. S. Tranylcypromine—a review. Clin. Pharmacol. Ther. 6: 631–655 (1965).

    PubMed  CAS  Google Scholar 

  31. Burrows, G. D., Davies, B., and Kinkaid-Smith, P. Unique tubular lesions after lithium. Lancet 1: 1310 (1978).

    Article  PubMed  CAS  Google Scholar 

  32. Cattell, W. R., Coppen, A., Bailey, J., and Rama Rao, V. A. Impairment of renal-concentrating capacity by lithium. Lancet 2: 44–45 (1978).

    Article  PubMed  CAS  Google Scholar 

  33. Gelenberg, A. J. Lithium and the kidney. Mass. Gen. Hosp. Biol. Ther. Psychiatry Newsletter 1: 25–28 (1978).

    Google Scholar 

  34. Baldessarini, R. J. Biomedical Aspects of Depression, Washington, D.C.: APA Press Inc., 1982 (in press).

    Google Scholar 

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Authors
  1. Ross J. Baldessarini M.D.
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Editors and Affiliations

  1. Health Services Research and Development Center, The Johns Hopkins Medical Institutions, USA

    Ivan Barofsky Ph.D.

  2. McLean Hospital Department of Psychiatry, Harvard Medical School, USA

    Richard D. Budson M.D. (Director, Community Residential Services) (Director, Community Residential Services)

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© 1983 Spectrum Publications, Inc.

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Baldessarini, R.J. (1983). Clinical Pharmacology and Side Effects of Antipsychotic and Mood-Stabilizing Drugs used in the Treatment of Psychiatric Patients with Chronic or Recurrent Disorders. In: Barofsky, I., Budson, R.D. (eds) The Chronic Psychiatric Patient in the Community. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6308-8_13

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  • DOI: https://doi.org/10.1007/978-94-011-6308-8_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6310-1

  • Online ISBN: 978-94-011-6308-8

  • eBook Packages: Springer Book Archive

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