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Spinal Cord Injury pp 3–14Cite as

Glial Fibrillary Acidic Protein (GFA) and Neuroglial Scarring, A Review

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Abstract

A major goal of spinal cord injury research is to promote a vigorous growth of axons in mammalian spinal cord following transection, which is comparable to the regeneration that occur in fish and amphibia. The studies of Windle suggest that axons in the mammalian spinal cord are capable of regenerating and that the growth is aborted because of a dense neuroglial and connective tissue scar that develops at the site of transection. Yet, by the use of pharmacological agents (steroid hormones, pyrogenic drugs), it is possible to “loosen” the scar and thus allow regeneration to proceed for a longer period (Windle, 1956; Windle et al., 1956). More recently, similar conclusions have been reached by Matinian and Andreasian (1976).

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Authors
  1. A. Bignami
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  2. D. Dahl
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Editors and Affiliations

  1. Institute of Rehabilitation Medicine, New York University Medical Center, N.Y., USA

    N. Eric Naftchi Ph.D.

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Bignami, A., Dahl, D. (1982). Glial Fibrillary Acidic Protein (GFA) and Neuroglial Scarring, A Review. In: Naftchi, N.E. (eds) Spinal Cord Injury. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6305-7_1

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  • DOI: https://doi.org/10.1007/978-94-011-6305-7_1

  • Publisher Name: Springer, Dordrecht

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