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Is normothermic preservation an alternative to hypothermic preservation?

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Book cover Organ Preservation

Abstract

Currently, clinical preservation is at a standstill, the approximate maximum safe cold periods for kidneys, livers and hearts being 72, 10 1/2 and 3 1/2h, respectively; a tiny fraction of their in vivo lifespan1–3. Neither the exact nature of the limiting factors nor a method for circumventing them is at hand. It seems likely that inactivation of the sodium pump, depletion of respiratory chain nucleotides, cellular swelling and/or membrane injury result in deterioration of the organ over time1.

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References

  1. Belzer, F.O., Hoffmann, R.M. and Southard, J.H. (1978). Kidney preservation. Surg. Clin. N. Am., 58, 261

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  2. Calne, R. Y. (1978). Hepatic transplantation - 1978. Surg. Clin. N. Am., 58, 321

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  5. Geyer, R.P. (1973). Fluorocarbon-polyol artificial blood substitutes. N. Engl. J. Med., 289, 1077

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  6. Grover, F.L., Amundsen, D. and Warden, J.L. (1974). The effect of Pluronic F-68 on circulatory dynamics and renal and carotid artery flow during hemorrhagic shock. J. Surg. Res., 17, 30

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Authors
  1. R. N. Dunn
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  2. F. K. Merkel
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  3. D. Roseman
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  4. M. Haklin
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  5. K. English
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Editor information

Editors and Affiliations

  1. MRC Medical Cryobiology Group, University Department of Surgery, Douglas House,Trumpington Road, CB2 2AH, Cambridge, UK

    D. E. Pegg

  2. Department of Nephrology, University Hospital, DK-5000, Odense C, Denmark

    I. A. Jacobsen

  3. Department of Surgery, University of California Medical Center, 225 Dickinson Street, 92103, San Diego, California, USA

    N. A. Halasz

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© 1982 MTP Press Limited

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Dunn, R.N., Merkel, F.K., Roseman, D., Haklin, M., English, K. (1982). Is normothermic preservation an alternative to hypothermic preservation?. In: Pegg, D.E., Jacobsen, I.A., Halasz, N.A. (eds) Organ Preservation. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6267-8_38

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  • DOI: https://doi.org/10.1007/978-94-011-6267-8_38

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6269-2

  • Online ISBN: 978-94-011-6267-8

  • eBook Packages: Springer Book Archive

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